499 | id == 499
499 | category_id == 28
499 | category_order == 25
499 | category_name == Joint Inflammation
499 | category_color == #C47AC0
499 | slug == LBH-rheumatoid-arthritis
499 | title == A Genetic Link Between Joint Cell Expansion & Rheumatoid Arthritis (LBH)
499 | meta_description == LBH regulates joint cell expansion. Variants of LBH have been associated with rheumatoid arthritis. Read more here.
499 | summary == <p style="text-align:justify"><strong>The <em>LBH</em> gene helps regulate the growth and expansion of cells involved in rheumatoid arthritis progression. Read more to learn how variants of <em>LBH</em> may increase the risk of this autoimmune disorder, and how you may be able to counter their effects.&nbsp;</strong></p>
499 | overall_score_text == Your Rheumatoid Arthritis Score (based on LBH gene)
499 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/LBH-YPEL5-Rheumatoid-arthritis.jpg
499 | author_id == 14
499 | author_name == Shany Lahan
499 | author_title == MS (Neuroscience)
499 | author_order == 5
499 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
499 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
499 | reviewer == None
499 | medical_reviewer_id == 11
499 | medical_reviewer_name == Puya Yazdi
499 | medical_reviewer_title == MD
499 | publish_date == 2020
499 | publish_date == 11
499 | publish_date == 23
499 | avg_rating == 5.0
499 | tags_id == 939
499 | tags_name == Fibroblast-Like Synoviocytes
499 | tags_id == 24
499 | tags_name == Inflammation
499 | tags_id == 965
499 | tags_name == LBH Gene
499 | tags_id == 369
499 | tags_name == NF-κB
499 | tags_id == 941
499 | tags_name == Synovial Joint
499 | permissions_favorite == False
499 | permissions_rate == False
499 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">LBH helps regulate the growth and expansion of cells involved in joint destruction. Variants of </span><em><span style="font-weight: 400;">LBH </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by decreasing the production of LBH. Diet and supplement modifications may counteract the effects of these variants by increasing LBH production.</span></span></p> <h2 style="text-align: justify;"><strong><em>LBH</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/lbh/"><em><span style="font-weight: 400;">LBH</span></em></a> <span style="font-weight: 400;">gene codes for limb-bud and heart development (LBH), a protein that helps regulate the growth and expansion of a type of cell called fibroblast-like synoviocyte [</span><a href="https://www.ncbi.nlm.nih.gov/gene/81606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Fibroblast-like synoviocytes are found in the most mobile and common type of joint in the human body: the synovial joint. When dysregulated, these cells may induce the progression of rheumatoid arthritis by releasing inflammatory proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306636/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130137/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, low levels of LBH may damage the DNA of fibroblast-like synoviocytes. DNA damage has been shown to promote the excessive expansion (proliferation) of these cells, joint inflammation, and joint destruction [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">As LBH also suppresses </span><a href="https://selfhacked.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;">, low LBH levels may further promote inflammation by enabling NF-kB activation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23807646/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">LBH </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may decrease production of LBH, leading to dysregulated fibroblast-like synoviocyte development and consequent joint inflammation and destruction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30549979/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>LBH</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*2741903804482195*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>LBH </em></strong><a href="https://selfdecode.com/snp/rs7579944/"><strong>rs7579944</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNP:</strong></p> <p style="text-align: justify;"><strong><em>LBH </em></strong><a href="https://selfdecode.com/snp/rs10175798/"><strong>rs10175798</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with rheumatoid arthritis</span></li> </ul> <p style="text-align: justify;">*7812007094044704*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*9497448405530844*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Pentanal, a compound found in olive oil, increased the production of LBH in human cells. In a randomized controlled trial, the Mediterranean diet lowered inflammation by reducing levels of NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22085595/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage rheumatoid arthritis by increasing the production of LBH and lowering levels of NF-kB.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Curcumin</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the main active compound of turmeric.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a cell-based study, curcumin was reported to increase the production of LBH by 16-fold [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Curcumin reduced some symptoms of rheumatoid arthritis in multiple studies. At high doses, it improved pain, morning stiffness, joint inflammation, and mobility [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7390600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28850308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22407780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, curcumin does not appear to be effective at lower doses. In the available studies, patients only benefited when consuming at least 500 mg per day [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31482684/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin may help manage rheumatoid arthritis by increasing the production of LBH.</span></p> <h4 style="text-align: justify;"><strong>Quercetin</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In a cell-based study, the antioxidant </span><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">quercetin</span></a><span style="font-weight: 400;"> increased LBH production; in another study, quercetin triggered the death of fibroblast-like synoviocytes derived from rheumatoid arthritis patients. Taken together, these studies suggest that quercetin-mediated LBH production may help regulate fibroblast-like synoviocytes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21632981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28026003"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A clinical trial of patients with rheumatoid arthritis found that consuming lots of raw berries, fruits, vegetables, nuts, roots, seeds, and sprouts rich in quercetin and other antioxidants reduced rheumatoid arthritis symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11156742"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Quercetin was reported to reduce some inflammatory markers and symptoms of rheumatoid arthritis (such as joint stiffness and pain) in one randomized controlled trial, but did not have any effect on inflammation and related symptoms in another trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24829713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27710596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Quercetin may help manage rheumatoid arthritis by increasing the production of LBH.&nbsp;</span></p>
499 | content_snp_table_2741903804482195_key == 2741903804482195
499 | content_snp_table_2741903804482195_blur == True
499 | content_snp_table_2741903804482195_hidden == False
499 | content_learn_more_7812007094044704_key == 7812007094044704
499 | content_learn_more_7812007094044704_blur == True
499 | content_learn_more_7812007094044704_hidden == False
499 | content_learn_more_7812007094044704_text == Based on the variants we looked at, your LBH gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Adhering to the Mediterranean diet, taking curcumin supplements, and taking quercetin supplements may help. Keep scrolling to find out more.
499 | content_recommendation_9497448405530844_key == 9497448405530844
499 | content_recommendation_9497448405530844_blur == True
499 | content_recommendation_9497448405530844_hidden == False
rsIDs = rs10175798,rs7579944
rsStatus = rs10175798,,chr2,30226728,G,A,T,,17,23,HET
rsStatus = rs7579944,,chr2,30222160,T,C,G,,11,18,HET
