500 | id == 500
500 | category_id == 28
500 | category_order == 25
500 | category_name == Joint Inflammation
500 | category_color == #C47AC0
500 | slug == COG6-rheumatoid-arthritis
500 | title == How Basic Cell Function Affects Rheumatoid Arthritis (COG6)
500 | meta_description == The COG6 gene encodes a protein with an essential function in every cell in the body. How does it affect rheumatoid arthritis?
500 | summary == <p><strong>The <em>COG6 </em>gene encodes a protein with a central &amp; essential function in every cell in the body. How does it affect rheumatoid arthritis? Find out here.</strong></p>
500 | overall_score_text == Your Arthritis Score (based on COG6)
500 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/COG6-LHFPL6-Rheumatoid-arthritis.jpg
500 | author_id == 1
500 | author_name == Jasmine Foster
500 | author_title == BSc, BEd
500 | author_order == 36
500 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
500 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
500 | reviewer == None
500 | medical_reviewer_id == 11
500 | medical_reviewer_name == Puya Yazdi
500 | medical_reviewer_title == MD
500 | publish_date == 2020
500 | publish_date == 11
500 | publish_date == 23
500 | avg_rating == 5.0
500 | tags_id == 33
500 | tags_name == Autoimmunity
500 | tags_id == 969
500 | tags_name == Cell Function
500 | tags_id == 967
500 | tags_name == COG6 Gene
500 | tags_id == 968
500 | tags_name == Golgi Apparatus
500 | tags_id == 95
500 | tags_name == Immune System
500 | tags_id == 24
500 | tags_name == Inflammation
500 | tags_id == 82
500 | tags_name == Rheumatoid Arthritis
500 | permissions_favorite == False
500 | permissions_rate == False
500 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> encodes conserved oligomeric Golgi complex subunit 6. Variants of </span><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> may play a role in rheumatoid arthritis by increasing immune system activity and antibody production through </span><em><span style="font-weight: 400;">ADAM33</span></em><span style="font-weight: 400;">. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by regulating </span><em><span style="font-weight: 400;">ADAM33</span></em><span style="font-weight: 400;">.</span></p> <h2><strong><em>COG6</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/cog6/"><em><span style="font-weight: 400;">COG6</span></em></a> <span style="font-weight: 400;">gene encodes a protein called conserved oligomeric Golgi complex subunit 6. This protein is part of the Golgi apparatus, an important structure for the basic function of all cells [</span><a href="https://www.ncbi.nlm.nih.gov/gene/57511"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because </span><em><span style="font-weight: 400;">COG6 </span></em><span style="font-weight: 400;">has such an important, central function, it&rsquo;s not surprising that variations in this gene can cause disabling results. COG6 deficiency is the name given to any disorder caused by a lack of COG6; symptoms of these disorders may include [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509899/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26260076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Physical deformities</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Uncoordinated movement</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cognitive slowness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Inflammatory bowel disease (</span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;">)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Liver disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Recurrent infections</span></li> </ul> <p><span style="font-weight: 400;">Most variants in the </span><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> gene do not have a strong enough effect to cause COG6 deficiency outright. However, less severe variants have been associated with rheumatoid arthritis and other autoimmune conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27193031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have speculated that COG6 affects the immune system through the ADAM proteases, including </span><a href="https://selfdecode.com/gene/adam33/"><em><span style="font-weight: 400;">ADAM33</span></em></a><span style="font-weight: 400;">, which has itself been implicated in inflammatory disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Patients with COG6 deficiencies typically have immune deficiencies and very low antibody production. People with rheumatoid arthritis usually have the opposite problem: an overactive immune system and high antibody production against the body&rsquo;s own tissues [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> gene encodes a part of the Golgi apparatus, which is essential to the function of every cell in the body. </span><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> may alter the function of the immune system through the </span><em><span style="font-weight: 400;">ADAM33</span></em><span style="font-weight: 400;"> signalling pathway, leading to increased rates of rheumatoid arthritis.</span></span></p> <h2><strong>Your </strong><strong><em>COG6</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p>*9119430234039686*</p> <p><a href="https://selfdecode.com/gene/cog6/"><strong>COG6</strong></a> <a href="https://selfdecode.com/snp/rs9603618/"><strong>rs9603618</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may slightly reduce immune system activity and the production of antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/cog6/"><strong>COG6</strong></a> <a href="https://selfdecode.com/snp/rs9603616/"><strong>rs9603616</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may slightly reduce immune system activity and the production of antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*7969954732197555*</p> <h2><strong>Recommendations for Reducing Arthritic Inflammation</strong></h2> <p>*7459482219985245*</p> <h3><strong>Pomegranate</strong></h3> <p><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">Pomegranate</span></a><span style="font-weight: 400;"> is rich in antioxidant compounds that may help regulate </span><em><span style="font-weight: 400;">ADAM33</span></em><span style="font-weight: 400;"> and other markers of autoimmune inflammation. Researchers believe that COG6 affects the immune system in part through </span><em><span style="font-weight: 400;">ADAM33</span></em><span style="font-weight: 400;">. Antioxidant-rich pomegranate may therefore be helpful for people with certain </span><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353401/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a small, open-label study, rheumatoid arthritis patients who drank a concentrated </span><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">pomegranate</span></a><span style="font-weight: 400;"> juice extract once a day had improved inflammation and </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;"> markers after twelve weeks. However, this study only had eight participants and no control group, so more research is needed to explore these effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21910371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In rat models of rheumatoid arthritis, pomegranate rind extract reduced </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> and swelling. These effects were attributed to decreases in the activity of inflammatory markers, including </span><a href="https://selfhacked.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31368549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Pomegranate is rich in antioxidants that may help regulate </span><em><span style="font-weight: 400;">ADAM33</span></em><span style="font-weight: 400;">. Pomegranate juice has also produced promising results in people with rheumatoid arthritis.</span></span></p> <h3><strong>Zinc</strong></h3> <p><span style="font-weight: 400;">ADAM33, which is involved in the downstream signalling effects of COG6, requires </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> in order to function correctly [</span><a href="https://www.atsjournals.org/doi/10.1164/rccm.200512-1946OC"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Meanwhile, people with rheumatoid arthritis have lower average zinc levels in their hair, which may indicate a tendency to have low zinc over a long period of time. Because of the connection with ADAM33, rheumatoid arthritis patients with </span><em><span style="font-weight: 400;">COG6</span></em><span style="font-weight: 400;"> variants should make sure that they have sufficient zinc intake [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187853/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Zinc is available in supplement form, and the richest dietary sources are oysters, other seafood, and beef [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">COG6 influences the immune system through ADAM33, and ADAM33 requires zinc to function. People with rheumatoid arthritis, meanwhile, appear more likely to be deficient in zinc over the long term.</span></p>
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500 | content_learn_more_7969954732197555_text == Based on the variants we looked at, your COG6 gene is somewhat associated with an overactive immune system. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Pomegranate and zinc may help. Keep scrolling to find out more.
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rsIDs = rs9603618,rs9603616
rsStatus = rs9603618,,chr13,39797240,C,T,,,32,0,Normal
