501 | id == 501
501 | category_id == 28
501 | category_order == 25
501 | category_name == Joint Inflammation
501 | category_color == #C47AC0
501 | slug == TRAF1-rheumatoid-arthritis
501 | title == An Inflammatory Protein Suppressor & Its Role in Rheumatoid Arthritis (TRAF1)
501 | meta_description == TRAF1 helps suppress protein activity. Variants of TRAF1 have been associated with rheumatoid arthritis. Read more here.
501 | summary == <p style="text-align:justify"><strong>TRAF1<em> </em>may help suppress the activity of an inflammatory protein. How might <em>TRAF1</em> variants increase the risk of rheumatoid arthritis? Read more to find out.</strong><br />  &nbsp;</p>
501 | overall_score_text == Your Rheumatoid Arthritis Score (based on TRAF1 gene)
501 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PHF19-TRAF1-PSMD5-Rheumatoid-arthritis.jpg
501 | author_id == 14
501 | author_name == Shany Lahan
501 | author_title == MS (Neuroscience)
501 | author_order == 5
501 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
501 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
501 | reviewer == None
501 | medical_reviewer_id == 11
501 | medical_reviewer_name == Puya Yazdi
501 | medical_reviewer_title == MD
501 | publish_date == 2020
501 | publish_date == 11
501 | publish_date == 24
501 | avg_rating == 5.0
501 | tags_id == 972
501 | tags_name == A20
501 | tags_id == 926
501 | tags_name == Autoantibodies
501 | tags_id == 33
501 | tags_name == Autoimmunity
501 | tags_id == 24
501 | tags_name == Inflammation
501 | tags_id == 369
501 | tags_name == NF-κB
501 | tags_id == 971
501 | tags_name == TNF
501 | tags_id == 970
501 | tags_name == TRAF1 Gene
501 | permissions_favorite == False
501 | permissions_rate == False
501 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">TRAF1 </span></em><span style="font-weight: 400;">gene codes for part of a protein that interacts with protein A20 in order to suppress inflammation. Variants of </span><em><span style="font-weight: 400;">TRAF1 </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by dysregulating the production of TRAF1. Supplement modifications may counteract the effects of these variants by increasing A20 production or activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>TRAF1</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><a href="https://selfhack.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">Tumor necrosis factor</span></a><span style="font-weight: 400;"> (</span><a href="https://selfhack.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF</span></a><span style="font-weight: 400;">) is a pro-inflammatory protein that has been suggested to play a major role in rheumatoid arthritis progression. This may be due to its ability to activate </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8849369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB may stimulate the release of inflammatory proteins, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/traf1/"><em><span style="font-weight: 400;">TRAF1</span></em></a> <span style="font-weight: 400;">gene codes for tumor necrosis factor receptor-associated factor 1 (TRAF1), part of a protein that may interact with </span><a href="https://selfdecode.com/blog/article/TNFAIP3-rheumatoid-arthritis-498/"><span style="font-weight: 400;">A20</span></a><span style="font-weight: 400;"> in order to suppress TNF activity and prevent NF-kB activation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11672546/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8692885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although this implies that a low amount of TRAF1 may result in inflammation, high amounts of TRAF1 have also been linked to inflammation -- suggesting that TRAF1 dysregulation can have deleterious effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26860405/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">TRAF1 </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may dysregulate the production of TRAF1, which may lead to excess NF-kB production, inflammatory protein release, and autoantibody formation</span> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27893701/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26860405/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>TRAF1 </em></strong><strong>Results for Rheumatoid Arthritis&nbsp;</strong></h2> <p style="text-align: justify;">*9281775865201516*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>TRAF1 </em></strong><a href="https://selfdecode.com/snp/rs10985070/"><strong>rs10985070</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of rheumatoid arthritis, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of rheumatoid arthritis, relative to &lsquo;C&rsquo;&nbsp;</span></li> </ul> <p style="text-align: justify;">*8180498771735247*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*5099492964027095*</p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Vitamin E</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Various forms of </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> have been reported to increase the production of A20 and suppress NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30471562/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26002975/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689338/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">One study found that vitamin E supplements (600 mg twice a day for twelve weeks) added to conventional rheumatoid arthritis therapy improved pain but not inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752293/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In multiple studies of animals with rheumatoid arthritis, vitamin E slowed the progression of joint destruction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25114906/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10613412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11840456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin E may help manage rheumatoid arthritis by increasing production of A20 and suppressing NF-kB.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Resveratrol</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> is an antioxidant and anti-inflammatory substance found in grapes and wine. It is also available in supplement form.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Resveratrol was found to lower inflammation in rats by suppressing NF-kB. This effect was attributed to increased production and activity of A20 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31846697/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of 100 rheumatoid arthritis patients, 1 g of resveratrol per day significantly improved swelling, tenderness, and disease activity scores. Resveratrol also decreased lab markers of inflammation and disease severity. The authors suggested that resveratrol could make a good addition to conventional treatment plans [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29611086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resveratrol may help manage rheumatoid arthritis by increasing production and activity of A20 and suppressing NF-kB.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Sesamin</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Sesamin is an active compound found in sesame, camphor, and other plants.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similar to resveratrol, sesamin lowered inflammation in rats by increasing the production and activity of A20 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33182047/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of 44 rheumatoid arthritis patients, sesamin supplements reduced joint pain and tenderness and improved lab markers of inflammation [</span><a href="https://pubchem.ncbi.nlm.nih.gov/compound/sesamin"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31309643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sesamin may help manage rheumatoid arthritis by increasing production and activity of A20.</span></p>
501 | content_snp_table_9281775865201516_key == 9281775865201516
501 | content_snp_table_9281775865201516_blur == True
501 | content_snp_table_9281775865201516_hidden == False
501 | content_learn_more_8180498771735247_key == 8180498771735247
501 | content_learn_more_8180498771735247_blur == True
501 | content_learn_more_8180498771735247_hidden == False
501 | content_learn_more_8180498771735247_text == Based on the variants we looked at, your TRAF1 gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Vitamin E, resveratrol, and sesamin supplements may help. Keep scrolling to find out more.
501 | content_recommendation_5099492964027095_key == 5099492964027095
501 | content_recommendation_5099492964027095_blur == True
501 | content_recommendation_5099492964027095_hidden == False
rsIDs = rs10985070
rsStatus = rs10985070,PHF19,chr9,120873843,C,A,G,,19,21,HET
