502 | id == 502
502 | category_id == 28
502 | category_order == 25
502 | category_name == Joint Inflammation
502 | category_color == #C47AC0
502 | slug == HLA-DOB-rheumatoid-arthritis
502 | title == Faulty Immune Response in Rheumatoid Arthritis (HLA-DOB)
502 | meta_description == The HLA-DOB gene plays a role in immune response & autoimmunity. Click to learn about its link with rheumatoid arthritis.
502 | summary == <p style="text-align:justify"><strong>Did you know that genes play a big part in autoimmunity? Read this post to learn about the link between <em>HLA-DOB</em> and rheumatoid arthritis, and get tailored tips!</strong></p>
502 | overall_score_text == Your Rheumatoid Arthritis Score (based on HLA-DOB gene)
502 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HLA-DOB-Rheumatoid-arthritis.jpg
502 | author_id == 9
502 | author_name == Aleksa Ristic
502 | author_title == MS (Pharmacy)
502 | author_order == 45
502 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
502 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
502 | reviewer == None
502 | medical_reviewer_id == 11
502 | medical_reviewer_name == Puya Yazdi
502 | medical_reviewer_title == MD
502 | publish_date == 2020
502 | publish_date == 11
502 | publish_date == 24
502 | avg_rating == 5.0
502 | tags_id == 33
502 | tags_name == Autoimmunity
502 | tags_id == 422
502 | tags_name == HLA complex
502 | tags_id == 973
502 | tags_name == HLA-DOB
502 | tags_id == 24
502 | tags_name == Inflammation
502 | tags_id == 82
502 | tags_name == Rheumatoid Arthritis
502 | permissions_favorite == False
502 | permissions_rate == False
502 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The HLA-DOB gene helps make a specific protein on white blood cells. Its excess activity may stimulate the immune cells to attack joint cartilage and cause inflammation.<br /><br /></strong><strong>Specific gene variants may increase HLA-DOB activity. They&rsquo;ve been associated with higher rheumatoid arthritis rates.<br /><br /></strong><strong>This post reveals simple ways to improve your joint health by targeting the HLA-DOB variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>HLA Genes, Autoimmunity &amp; Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/hla-dob/"><em><span style="font-weight: 400;">HLA-DOB</span></em></a><span style="font-weight: 400;"> gene helps make a specific protein on</span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"> <span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;">. HLA-DOB flags harmful external components and stimulates the immune response against them [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3112"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with rheumatoid arthritis and other autoimmune conditions, HLA proteins may have increased activity or impaired structure. These changes cause them to target the body&rsquo;s own components, such as joint cartilage, and trigger inflammation[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC474884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Studies have associated certain HLA-DOB variants with higher odds of rheumatoid arthritis, especially in smokers [</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23143596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26272072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your HLA-DOB Results for Rheumatoid Arthritis</strong></h2> <p>*3983328032113051*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs10484565/"><strong>rs10484565</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23143596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26272072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of developing rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely increases HLA-DOB activity.</span></li> </ul> <p><strong>Other Important SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs9784858/"><strong>rs9784858</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26272072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span><strong>&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of developing rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely increases HLA-DOB activity.</span></li> </ul> <p>*9853744343521336*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Joint Health</strong></h2> <p>*3027469633441744*</p> <h3><strong>Avoid Cigarette Smoke</strong></h3> <p><span style="font-weight: 400;">The link between HLA-DOB variants and rheumatoid arthritis is more pronounced in smokers [</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23143596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26272072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Smoking is one of the strongest environmental risk factors for developing rheumatoid arthritis. In one study, 88% of smokers tested positive for </span><a href="https://selfhacked.com/blog/rheumatoid-factor/"><span style="font-weight: 400;">rheumatoid factor</span></a><span style="font-weight: 400;"> in 10 years [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9833699"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other studies have reported up to 4 times higher odds of having elevated rheumatoid factor in smokers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004225/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16403829"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9306868"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10743800"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11085797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarette smoke can worsen the impact of your variants and contribute to rheumatoid arthritis.</span></p> <h3><strong>Sun Exposure &amp; Vitamin D</strong></h3> <p><span style="font-weight: 400;">Research suggests that UV light and </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> may have beneficial effects on autoimmunity by suppressing HLA proteins. Moderate </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun exposure</span></a><span style="font-weight: 400;"> is the best way to get both natural UV light and vitamin D [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603567/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16046118"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency is more common in patients with rheumatoid arthritis than in the general population [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with greater exposure to UV rays from the sun tend to have lower rheumatoid arthritis rates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678095/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to multiple studies, people with higher intake and blood levels of vitamin D appear less likely to develop rheumatoid arthritis. There are conflicting reports on whether vitamin D supplements can improve pain from rheumatoid arthritis, but they can prevent a deficiency from inadequate sun exposure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14730601/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22004229/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">By providing natural UV light and vitamin D, sun exposure may lessen the impact of your HLA-DOB variants on rheumatoid arthritis.</span></p> <h3><strong>Black Seed Oil</strong></h3> <p><a href="https://selfhacked.com/blog/black-cumin-seed-nigella-sativa-top-scientific-benefits/"><span style="font-weight: 400;">Black seed</span></a><span style="font-weight: 400;"> or black cumin has well-known anti-inflammatory properties. Its active ingredient, thymoquinone, may reduce the number of HLA proteins on immune cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20110691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Black seed oil (500mg, 2x daily) reduced joint stiffness and swelling in 40 women with rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22162258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In rats with arthritis, thymoquinone reduced inflammation and improved joint function [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22450443"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Black seed oil may improve rheumatoid arthritis by targeting your gene variant.</span></p>
502 | content_snp_table_3983328032113051_key == 3983328032113051
502 | content_snp_table_3983328032113051_blur == True
502 | content_snp_table_3983328032113051_hidden == False
502 | content_learn_more_9853744343521336_key == 9853744343521336
502 | content_learn_more_9853744343521336_blur == True
502 | content_learn_more_9853744343521336_hidden == False
502 | content_learn_more_9853744343521336_text == Based on the variants we looked at, your HLA-DOB gene is associated with slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Avoid cigarette smoke and get more sunlight to improve joint health by targeting your variants. Keep reading to learn more.
502 | content_recommendation_3027469633441744_key == 3027469633441744
502 | content_recommendation_3027469633441744_blur == True
502 | content_recommendation_3027469633441744_hidden == False
rsIDs = rs9784858,rs10484565
rsStatus = rs9784858,,chr6,32819398,G,C,,,7,1,HET
rsStatus = rs10484565,TAP2,chr6,32827255,G,A,,,6,0,Normal
