505 | id == 505
505 | category_id == 28
505 | category_order == 25
505 | category_name == Joint Inflammation
505 | category_color == #C47AC0
505 | slug == UBASH3A-rheumatoid-arthritis
505 | title == Immune Cell Inhibition in Rheumatoid Arthritis (UBASH3A)
505 | meta_description == UBASH3A helps regulate T cell activity. A variant of UBASH3A has been associated with rheumatoid arthritis. Read more here.
505 | summary == <p style="text-align:justify"><strong>UBASH3A helps suppress the activity of a cell critical for a variety of immune responses. Read more to find out how a variant of <em>UBASH3A</em> may promote rheumatoid arthritis progression, and how you may be able to mitigate its effects.&nbsp;</strong></p>
505 | overall_score_text == Your Rheumatoid Arthritis Score (based on UBASH3A gene)
505 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/UBASH3A-TMPRSS3-Rheumatoid-arthritis.jpg
505 | author_id == 14
505 | author_name == Shany Lahan
505 | author_title == MS (Neuroscience)
505 | author_order == 5
505 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
505 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
505 | reviewer == None
505 | medical_reviewer_id == 11
505 | medical_reviewer_name == Puya Yazdi
505 | medical_reviewer_title == MD
505 | publish_date == 2020
505 | publish_date == 11
505 | publish_date == 25
505 | avg_rating == 5.0
505 | tags_id == 33
505 | tags_name == Autoimmunity
505 | tags_id == 24
505 | tags_name == Inflammation
505 | tags_id == 369
505 | tags_name == NF-κB
505 | tags_id == 978
505 | tags_name == T Cell Receptor
505 | tags_id == 442
505 | tags_name == T Cells
505 | tags_id == 976
505 | tags_name == UBASH3A Gene
505 | tags_id == 977
505 | tags_name == ZAP-70
505 | permissions_favorite == False
505 | permissions_rate == False
505 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">UBASH3A </span></em><span style="font-weight: 400;">gene helps block the activity of ZAP-70, a protein involved in activating NF-kB. A variant of </span><em><span style="font-weight: 400;">UBASH3A </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by dysregulating UBASH3A, increasing ZAP-70 activity, and promoting inflammation. Lifestyle, diet, and supplement modifications may counteract the effects of this variant by suppressing ZAP-70 and/or NF-kB.</span></span></p> <h2 style="text-align: justify;"><strong><em>UBASH3A</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">T cells are critical components of the immune system, able to detect foreign substances (such as bacteria) through receptors on their surfaces. Activation of T cells through these receptors normally promotes targeted immune responses necessary for the eradication of foreign substances [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8619093/"><span style="font-weight: 400;">R</span></a>, <a href="https://www.ncbi.nlm.nih.gov/books/NBK27098/" target="_blank" rel="noopener">R</a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Unfortunately, when T cell activity is dysregulated, immune responses may mistakenly be targeted toward the body&rsquo;s own tissues. This is called </span><em><span style="font-weight: 400;">autoimmunity </span></em><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/8619093/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ubash3a/"><em><span style="font-weight: 400;">UBASH3A</span></em></a> <span style="font-weight: 400;">gene codes for ubiquitin-associated and SH3 domain-containing A (UBASH3A), an enzyme that suppresses T cell activity by blocking a protein called ZAP-70 [</span><a href="https://www.ncbi.nlm.nih.gov/gene/53347"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14738763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21393235/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25047644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">ZAP-70 plays many roles in T cells, including the activation of inflammatory protein </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [<a href="https://pubmed.ncbi.nlm.nih.gov/11231305/" target="_blank" rel="noopener">R</a>, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482087/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although this implies that a low amount of UBASH3A may result in inflammation, high amounts of this protein have also been linked to inflammation and autoimmunity -- suggesting that an imbalance in UBASH3A may have deleterious effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25047644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30822156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">UBASH3A </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may dysregulate the production of UBASH3A, resulting in ZAP-70 activation and subsequent inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30822156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25876712/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>UBASH3A</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*7340479560157046*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>UBASH3A </em></strong><a href="https://selfdecode.com/snp/rs1893592/"><strong>rs1893592</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26546613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of rheumatoid arthritis, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower odds of rheumatoid arthritis, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;">*9369093237632398*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*2620397025076530*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Aquatic Exercise</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Aquatic </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> describes any type of physical activity that takes place either partially or fully submerged in water. These activities can allow people to maintain physical fitness and reap the benefits of exercise even when they are not fully mobile out of the water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of mice, aquatic exercise lowered the activity of NF-kB, suggesting that it may benefit individuals carrying risk variants of </span><em><span style="font-weight: 400;">UBASH3A </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768972/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 clinical trials of over 250 people with rheumatoid arthritis, aquatic exercise produced the greatest pain reduction, in comparison to other types of exercise [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8971230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aquatic exercise may help manage rheumatoid arthritis by lowering the activity of NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and pain in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial, the Mediterranean diet lowered inflammation by reducing levels of NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22085595/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to one study of 51 rheumatoid arthritis patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage rheumatoid arthritis by lowering production of NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Glucosamine&nbsp;</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/glucosamine/"><span style="font-weight: 400;">Glucosamine</span></a><span style="font-weight: 400;"> was reported to lower the activity of T cells and consequently prevent NF-kB activation. This effect was partly attributed to reduced ZAP-70 activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23594311/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to preliminary research, glucosamine may reduce the pain from rheumatoid arthritis, while its effects on joint inflammation are less convincing [</span><a href="https://www.mayoclinic.org/drugs-supplements-glucosamine/art-20362874"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 51 patients, 3-month treatment with glucosamine notably improved rheumatoid arthritis symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16953394"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">On the other hand, a combination of glucosamine, chondroitin, and quercetin had no effect on 22 rheumatoid arthritis patients [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19202302"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In mice with rheumatoid arthritis, both glucosamine and </span><a href="https://selfhacked.com/blog/n-acetylglucosamine/"><span style="font-weight: 400;">N-acetyl-glucosamine</span></a><span style="font-weight: 400;"> (</span><a href="https://selfhacked.com/blog/n-acetylglucosamine/"><span style="font-weight: 400;">NAG</span></a><span style="font-weight: 400;">) suppressed joint inflammation and enhanced joint function [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22434264"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Glucosamine may help manage rheumatoid arthritis by lowering ZAP-70 and NF-kB activation. </span></p>
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505 | content_learn_more_9369093237632398_text == Based on the variants we looked at, your UBASH3A gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Adhering to the Mediterranean diet, participating in aquatic exercise, and taking glucosamine supplements may help. Keep scrolling to find out more.
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rsIDs = rs1893592
rsStatus = rs1893592,UBASH3A,chr21,42434957,A,C,G,,33,0,Normal
