509 | id == 509
509 | category_id == 28
509 | category_order == 25
509 | category_name == Joint Inflammation
509 | category_color == #C47AC0
509 | slug == TPD52-rheumatoid-arthritis
509 | title == A Link Between Metabolism & Rheumatoid Arthritis? (TPD52)
509 | meta_description == One genetic variant affects both TPD52 and DGAT1, which may alter drug effectiveness and fat metabolism in rheumatoid arthritis.
509 | summary == <p><strong>One genetic variant affects both <em>TPD52 </em>and <em>DGAT1</em>, which may alter drug effectiveness and fat metabolism in rheumatoid arthritis. Learn more here.</strong></p>
509 | overall_score_text == Your Arthritis Score (based on TPD52)
509 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TPD52-Rheumatoid-arthritis.jpg
509 | author_id == 1
509 | author_name == Jasmine Foster
509 | author_title == BSc, BEd
509 | author_order == 36
509 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
509 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
509 | reviewer == None
509 | medical_reviewer_id == 11
509 | medical_reviewer_name == Puya Yazdi
509 | medical_reviewer_title == MD
509 | publish_date == 2020
509 | publish_date == 11
509 | publish_date == 27
509 | avg_rating == 5.0
509 | tags_id == 33
509 | tags_name == Autoimmunity
509 | tags_id == 987
509 | tags_name == DGAT1 Gene
509 | tags_id == 570
509 | tags_name == Fat Metabolism
509 | tags_id == 95
509 | tags_name == Immune System
509 | tags_id == 24
509 | tags_name == Inflammation
509 | tags_id == 141
509 | tags_name == Metabolic Health
509 | tags_id == 82
509 | tags_name == Rheumatoid Arthritis
509 | tags_id == 985
509 | tags_name == TPD52 Gene
509 | permissions_favorite == False
509 | permissions_rate == False
509 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">TPD52</span></em><span style="font-weight: 400;"> encodes tumor protein D52, and </span><em><span style="font-weight: 400;">DGAT1</span></em><span style="font-weight: 400;"> encodes diacylglycerol O-acyltransferase 1. A variant that affects both </span><em><span style="font-weight: 400;">TPD52</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">DGAT1</span></em><span style="font-weight: 400;"> may play a role in rheumatoid arthritis by altering the response to immunosuppressant drugs and impairing sugar and fat metabolism. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by correcting metabolism.</span></p> <h2><strong><em>TPD52 </em></strong><strong>and Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tpd52/"><em><span style="font-weight: 400;">TPD52</span></em></a><span style="font-weight: 400;"> gene encodes tumor protein D52. We know very little about TPD52 except that it can be used as a biomarker for some forms of cancer and that it has been associated with rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7163"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859461/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264695/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/nature12873"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In cancer, lower levels of TPD52 are generally associated with worse outcomes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868759/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variations in </span><em><span style="font-weight: 400;">TPD52</span></em><span style="font-weight: 400;"> may affect whether or not certain rheumatoid arthritis treatments work well. In one study, researchers identified </span><em><span style="font-weight: 400;">TPD52</span></em><span style="font-weight: 400;"> as one of the rheumatoid arthritis susceptibility genes that might affect response to infliximab, a drug that suppresses the immune system [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264695/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK500021/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Another Possible Connection: </span><em><span style="font-weight: 400;">DGAT1</span></em></h3> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">TPD52 </span></em><span style="font-weight: 400;">variant that has been associated with rheumatoid arthritis, rs998731, may also affect the expression of another gene called </span><em><span style="font-weight: 400;">DGAT1. </span></em><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/dgat1/"><em><span style="font-weight: 400;">DGAT1</span></em></a> <span style="font-weight: 400;">gene encodes diacylglycerol O-acyltransferase 1 [</span><a href="https://www.ncbi.nlm.nih.gov/gene/8694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12743"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">DGAT1 affects the storage and metabolism of sugar and fat. Recently, some studies have found that rheumatoid arthritis patients are less likely to be able to process sugars and fats in a healthy way compared with healthy people [</span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12743"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">A genetic variant that may affect both </span><em><span style="font-weight: 400;">TPD52</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">DGAT1</span></em><span style="font-weight: 400;"> has been associated with rheumatoid arthritis. </span><em><span style="font-weight: 400;">TPD52</span></em><span style="font-weight: 400;"> is best known as a cancer biomarker, while </span><em><span style="font-weight: 400;">DGAT1</span></em><span style="font-weight: 400;"> affects sugar and fat metabolism.</span></span></p> <h2><strong>Your </strong><strong><em>TPD52</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p>*7198370970516675*</p> <p><a href="https://selfdecode.com/gene/tpd52/"><strong>TPD52</strong></a> <a href="https://selfdecode.com/snp/rs998731/"><strong>rs998731</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may alter the effectiveness of immunosuppressant drugs or change sugar and fat metabolism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264695/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12743"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*2503482719591399*</p> <h2><strong>Recommendations for Improving Arthritic Inflammation</strong></h2> <p>*6853950689354515*</p> <h3><strong>Aquatic Exercise</strong></h3> <p><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">TPD52 </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">DGAT1 </span></em><span style="font-weight: 400;">may alter sugar and fat metabolism in a harmful way. One study found that 45 minutes of hard </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> increased energy expenditure well after the physical activity was over. This revved up metabolism lasted for 14 hours [</span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12743"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21311363"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Exercise can increase muscle mass, which helps boost metabolism, even at rest [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2243122"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15952420"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9402941"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aquatic exercise is often recommended to patients with rheumatoid arthritis. Aquatic exercise describes any type of physical activity that takes place either partially or fully submerged in water. These activities can allow people to maintain physical fitness and reap the benefits of exercise even when they are not fully mobile out of the water [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials of over 250 people with rheumatoid arthritis comparing the effects of different types of exercise, aquatic exercise produced the greatest </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> reduction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8971230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aquatic exercise may help correct problems with metabolism and improve the symptoms of rheumatoid arthritis.</span></p> <h3><strong>Fish Oil</strong></h3> <p><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil</span></a><span style="font-weight: 400;">&rsquo;s anti-inflammatory effects have the ability to indirectly aid in fat metabolism in people with high inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18065585"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It can increase the secretion of</span><a href="https://selfhacked.com/blog/adiponectin/"><span style="font-weight: 400;"> adiponectin</span></a><span style="font-weight: 400;">, which is responsible for breaking down fats [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16567512"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplementation with </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> may lower the activity of chronic inflammatory and autoimmune diseases, including rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12480795"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11802309"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 17 trials found that supplemental fish oil reduced inflammatory joint </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis and other inflammatory conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17335973"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study of 250 patients, fish oil was as effective as ibuprofen in reducing pain caused by arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16531187"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Resolvins found in EPA and DHA appear to prevent certain inflammatory cytokines such as </span><a href="https://selfdecode.com/blog/article/tnf-longevity-86"><span style="font-weight: 400;">TNF</span></a><span style="font-weight: 400;">-&alpha; from inducing pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20383154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil may help improve fat metabolism and reduce inflammation and pain in rheumatoid arthritis.</span></p> <h3><strong>Vitamin E</strong></h3> <p><span style="font-weight: 400;">People with impaired fat metabolism, which may be caused by </span><em><span style="font-weight: 400;">DGAT1 </span></em><span style="font-weight: 400;">changes, are more likely to be deficient in vitamin E [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209463/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25489958"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15856761"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12743"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One study found that </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">vitamin E</span></a><span style="font-weight: 400;"> supplements (600 mg twice a day for twelve weeks), when added to conventional rheumatoid arthritis therapy, improved pain but not inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752293/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In multiple studies of animals with rheumatoid arthritis, vitamin E slowed the progression of joint destruction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25114906/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10613412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11840456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with </span><em><span style="font-weight: 400;">DGAT1</span></em><span style="font-weight: 400;"> variants may have impaired fat metabolism and may therefore be more susceptible to vitamin E deficiency.</span></span></p>
509 | content_snp_table_7198370970516675_key == 7198370970516675
509 | content_snp_table_7198370970516675_blur == True
509 | content_snp_table_7198370970516675_hidden == False
509 | content_learn_more_2503482719591399_key == 2503482719591399
509 | content_learn_more_2503482719591399_blur == True
509 | content_learn_more_2503482719591399_hidden == False
509 | content_learn_more_2503482719591399_text == Based on the variants we looked at, your TPD52 and DGAT1 genes are somewhat associated with impaired drug response and sugar & fat metabolism. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Aquatic exercise, fish oil, and vitamin E may help. Keep scrolling to find out more.
509 | content_recommendation_6853950689354515_key == 6853950689354515
509 | content_recommendation_6853950689354515_blur == True
509 | content_recommendation_6853950689354515_hidden == False
rsIDs = rs998731
rsStatus = rs998731,LOC105375920,chr8,80183160,C,G,T,,28,0,Normal
