510 | id == 510
510 | category_id == 28
510 | category_order == 25
510 | category_name == Joint Inflammation
510 | category_color == #C47AC0
510 | slug == ANKRD55-rheumatoid-arthritis
510 | title == Complex Inflammatory Signals in Rheumatoid Arthritis (ANKRD55)
510 | meta_description == The ANKRD55 gene is strongly associated with rheumatoid arthritis & variants may also affect IL-6 inflammatory signals.
510 | summary == <p><strong>The <em>ANKRD55 </em>gene is strongly associated with rheumatoid arthritis &amp; variants may also affect IL-6 inflammatory signals. Learn more about it here.</strong></p>
510 | overall_score_text == Your Arthritis Score (based on ANKRD55)
510 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ANKRD55-rheumatoid-arthritis.jpg
510 | author_id == 1
510 | author_name == Jasmine Foster
510 | author_title == BSc, BEd
510 | author_order == 36
510 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
510 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
510 | reviewer == None
510 | medical_reviewer_id == 11
510 | medical_reviewer_name == Puya Yazdi
510 | medical_reviewer_title == MD
510 | publish_date == 2020
510 | publish_date == 11
510 | publish_date == 27
510 | avg_rating == 5.0
510 | tags_id == 988
510 | tags_name == ANKRD55 Gene
510 | tags_id == 33
510 | tags_name == Autoimmunity
510 | tags_id == 96
510 | tags_name == Cytokines
510 | tags_id == 253
510 | tags_name == IL-6
510 | tags_id == 989
510 | tags_name == IL6ST Gene
510 | tags_id == 95
510 | tags_name == Immune System
510 | tags_id == 24
510 | tags_name == Inflammation
510 | tags_id == 82
510 | tags_name == Rheumatoid Arthritis
510 | permissions_favorite == False
510 | permissions_rate == False
510 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ANKRD55</span></em><span style="font-weight: 400;"> encodes ankyrin repeat domain 55. Variants of </span><em><span style="font-weight: 400;">ANKRD55</span></em><span style="font-weight: 400;"> may play a role in rheumatoid arthritis through changes in inflammatory signalling, including through the nearby </span><em><span style="font-weight: 400;">IL6ST</span></em><span style="font-weight: 400;"> gene. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by correcting IL-6 signalling.</span></p> <h2><strong><em>ANKRD55 </em></strong><strong>and Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ANKRD55/"><em><span style="font-weight: 400;">ANKRD55</span></em></a><span style="font-weight: 400;"> gene encodes a protein called ankyrin repeat domain 55.This gene is well-established as a potential risk factor for autoimmune diseases, including </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;">, Crohn&rsquo;s disease, and rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/gene/79722"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The function of ANKRD55 isn&rsquo;t very well understood, but it is abundant in immune tissues like the lymph nodes and has been strongly linked to autoimmunity. Because of this, it is assumed to play a role in inflammatory signalling [</span><a href="https://www.ncbi.nlm.nih.gov/gene/79722"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">A Secondary Association: </span><em><span style="font-weight: 400;">IL6ST</span></em></h3> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ANKRD55</span></em><span style="font-weight: 400;"> gene is physically close to another gene that may be affected by the same set of variants. The </span><a href="https://selfdecode.com/gene/il6st/"><em><span style="font-weight: 400;">IL6ST</span></em></a> <span style="font-weight: 400;">gene encodes a protein called interleukin 6 signal transducer; this protein affects the binding of cytokines, including </span><a href="http://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">, to their receptors on the surface of cells. In this way, it is important for inflammatory signalling [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3572"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-6 has been heavily implicated in rheumatoid arthritis through its influence on pathological inflammation. Rheumatoid arthritis patients tend to have significantly higher IL-6 levels than healthy people, and this high IL-6 can lead to increased destruction of joint tissues [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383508/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The ANKRD55 gene is strongly associated with rheumatoid arthritis &amp; variants may also affect IL-6 inflammatory signals.</span></p> <h2><strong>Your </strong><strong><em>ANKRD55</em></strong><strong> Results for Rheumatoid Arthritis</strong></h2> <p>*9488514626066609*</p> <p><a href="https://selfdecode.com/gene/ANKRD55/"><strong>ANKRD55</strong></a> <a href="https://selfdecode.com/snp/rs71624119/"><strong>rs71624119</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease the production of IL-6 and other inflammatory signals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/3572"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/ANKRD55/"><strong>ANKRD55</strong></a> <a href="https://selfdecode.com/snp/rs7731626/"><strong>rs7731626</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease the production of IL-6 and other inflammatory signals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/3572"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/ANKRD55/"><strong>ANKRD55</strong></a> <a href="https://selfdecode.com/snp/rs10065637/"><strong>rs10065637</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23143596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may decrease the production of IL-6 and other inflammatory signals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/3572"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/ANKRD55/"><strong>ANKRD55</strong></a> <a href="https://selfdecode.com/snp/rs10040327/"><strong>rs10040327</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively lower rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease the production of IL-6 and other inflammatory signals [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759997/"><span>R</span></a><span>, </span><a href="https://www.ncbi.nlm.nih.gov/gene/3572"><span>R</span></a><span>].</span></li> </ul> <p>*4567490083846961*</p> <h2><strong>Recommendations for Improving Arthritic Inflammation</strong></h2> <p>*7248303811567531*</p> <p><strong>Note</strong><span style="font-weight: 400;">: Little is known about the function of ANKRD55 or whether it is good or bad to increase or decrease it. As such, these recommendations focus on IL-6 signalling, which is much better-studied and affected by many of the same variants as the </span><em><span style="font-weight: 400;">ANKRD55</span></em><span style="font-weight: 400;"> gene.</span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">In a study of 345 middle-aged twin men, the twins who ate a Mediterranean diet significantly reduced circulating IL-6 compared to the twins who ate their typical diets. This diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> and vegetables, each of which has been independently linked to lower IL-6 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232063/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/19370776"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/pii/S0308814610003158"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet that may reduce swelling and </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> in arthritic joints [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to one study of 51 patients, those eating a Mediterranean diet had significantly higher vitality scores (a measurement of energy, quality of life, and general function) than those eating a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The anti-inflammatory effect of the Mediterranean diet may be due to its high content of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. In fact, people whose diets include a lot of olive oil are significantly less likely to develop rheumatoid arthritis than those who use other types of cooking oils [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People who eat a Mediterranean diet tend to have lower IL-6 and improved rheumatoid arthritis symptoms compared to those who eat a typical Western diet.</span></p> <h3><strong>Curcumin</strong></h3> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;">, a well-known anti-inflammatory compound extracted from turmeric, decreases IL-6 and may enhance other parts of the immune response. It also has shown anti-infective and antiviral activity, but its effect on coronaviruses is unknown [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17211725"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/18588355"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://ard.bmj.com/content/71/Suppl_1/A90.2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Curcumin reduced some symptoms of rheumatoid arthritis in multiple studies. At high doses, it improved pain, morning stiffness, joint inflammation, and mobility [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7390600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28850308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22407780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, curcumin does not appear to be effective at lower doses. In the available studies, patients only benefited when consuming at least 500 mg per day [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31482684/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin decreases IL-6, balances the immune response, and may reduce rheumatoid arthritis symptoms.</span></p> <h3><strong><em>Lactobacillus casei</em></strong></h3> <p><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotic</span></a><span style="font-weight: 400;"> supplements, including </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">Lactobacillus casei</span></em></a><span style="font-weight: 400;">, have been found to decrease IL-6 and reduce inflammation [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/19161443"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/16467329"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979858/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21504972"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials on over 100 people with rheumatoid arthritis, supplementation with a </span><a href="http://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">L. casei</span></em></a><span style="font-weight: 400;"> strain for 8 weeks reduced joint pain and inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24355439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24673738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This strain also relieved rheumatoid arthritis in mice and rats [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21810608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20838859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18804867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">L. casei</span></em> <a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> may decrease IL-6, inflammation, and joint pain in rheumatoid arthritis.</span></span></p>
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510 | content_learn_more_4567490083846961_text == Based on the variants we looked at, your ANKRD55 and IL6ST genes are somewhat associated with autoimmune inflammation. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. A Mediterranean diet, curcumin, and L. casei probiotics may help. Keep scrolling to find out more.
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rsIDs = rs71624119,rs10040327,rs7731626,rs10065637
rsStatus = rs71624119,ANKRD55,chr5,56144903,G,A,C,,28,0,Normal
rsStatus = rs10040327,ANKRD55,chr5,56139393,C,A,T,,31,0,Normal
rsStatus = rs7731626,ANKRD55,chr5,56148856,G,A,C,,31,0,Normal
rsStatus = rs10065637,ANKRD55,chr5,56143024,C,T,,,51,0,Normal
