511 | id == 511
511 | category_id == 28
511 | category_order == 25
511 | category_name == Joint Inflammation
511 | category_color == #C47AC0
511 | slug == DRAIC-rheumatoid-arthritis
511 | title == Inactivation of an Inflammatory Protein in Rheumatoid Arthritis (DRAIC)
511 | meta_description == DRAIC blocks inflammatory protein activation. A variant of DRAIC has been linked to rheumatoid arthritis. Read more here.
511 | summary == <p style="text-align:justify"><strong><em>DRAIC</em> helps prevent the activation of an inflammatory protein. How might a variant of <em>DRAIC</em> hinder this function and promote rheumatoid arthritis? Read more to find out.</strong></p>
511 | overall_score_text == Your Rheumatoid Arthritis Score (based on DRAIC gene)
511 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RPLP1-DRAIC-Rheumatoid-arthritis.jpg
511 | author_id == 14
511 | author_name == Shany Lahan
511 | author_title == MS (Neuroscience)
511 | author_order == 5
511 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
511 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
511 | reviewer == None
511 | medical_reviewer_id == 11
511 | medical_reviewer_name == Puya Yazdi
511 | medical_reviewer_title == MD
511 | publish_date == 2020
511 | publish_date == 11
511 | publish_date == 27
511 | avg_rating == 5.0
511 | tags_id == 926
511 | tags_name == Autoantibodies
511 | tags_id == 33
511 | tags_name == Autoimmunity
511 | tags_id == 990
511 | tags_name == DRAIC Gene
511 | tags_id == 991
511 | tags_name == IkBa
511 | tags_id == 24
511 | tags_name == Inflammation
511 | tags_id == 369
511 | tags_name == NF-κB
511 | tags_id == 992
511 | tags_name == Phosphorylation
511 | permissions_favorite == False
511 | permissions_rate == False
511 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">DRAIC </span></em><span style="font-weight: 400;">helps regulate an inflammatory protein by preventing the attachment of phosphate compounds (</span><em><span style="font-weight: 400;">phosphorylation</span></em><span style="font-weight: 400;">) to IkBa. A variant of </span><em><span style="font-weight: 400;">DRAIC </span></em><span style="font-weight: 400;">may play a role in rheumatoid arthritis by reducing </span><em><span style="font-weight: 400;">DRAIC </span></em><span style="font-weight: 400;">activity and promoting the phosphorylation of IkBa. Lifestyle and supplement modifications may counteract the effects of this variant by preventing IkBa phosphorylation and suppressing an inflammatory protein.</span></span></p> <h2 style="text-align: justify;"><strong><em>DRAIC</em></strong><strong> and Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/draic/"><em><span style="font-weight: 400;">DRAIC</span></em></a> <span style="font-weight: 400;">gene does not code for a protein. Instead, this gene helps regulate </span><a href="https://selfhacked.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB may stimulate the production of inflammatory proteins, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB is normally held in an inactive state by IkBa.</span> <span style="font-weight: 400;">The attachment of phosphate compounds (</span><em><span style="font-weight: 400;">phosphorylation</span></em><span style="font-weight: 400;">) to IkBa results in IkBa breakdown and in turn, the release and activation of NF-kB [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">One study has suggested that </span><em><span style="font-weight: 400;">DRAIC </span></em><span style="font-weight: 400;">may block the activity of proteins that attach phosphate compounds to IkBa, thereby preventing NF-kB activation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">DRAIC </span></em><span style="font-weight: 400;">have been associated with rheumatoid arthritis. These variants may reduce the activity of </span><em><span style="font-weight: 400;">DRAIC</span></em><span style="font-weight: 400;">, resulting in NF-kB activation, inflammation, and autoantibody formation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>DRAIC</em></strong><strong> Results for Rheumatoid Arthritis&nbsp;</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">*8649156573196042*</span></p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>DRAIC </em></strong><a href="https://selfdecode.com/snp/rs8026898/"><strong>rs8026898</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30423114"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of rheumatoid arthritis&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with rheumatoid arthritis&nbsp;</span></li> </ul> <p style="text-align: justify;">*3085206629646486*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Rheumatoid Arthritis</strong></h2> <p style="text-align: justify;">*2243417236474791*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Sun Exposure</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun</span></a><span style="font-weight: 400;"> is the best source of </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;">. Multiple studies have shown that low levels of vitamin D may activate NF-kB due to the phosphorylation and subsequent breakdown of IkBa, and that vitamin D treatment may reverse these effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19931640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16455676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D deficiency is more common in patients with rheumatoid arthritis than in the general population [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A study of nurses found that those with greater exposure to UVB rays from the sun had the lowest rates of rheumatoid arthritis. Another study found that people who live further from the equator (who are likely to be exposed to less sunlight on average) are more likely to develop rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678095/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to multiple studies, people with a higher intake of vitamin D appear less likely to develop rheumatoid arthritis. However, there are conflicting reports on whether supplementing with vitamin D can improve pain in existing rheumatoid arthritis cases [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14730601/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22004229/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The sun is the best source of vitamin D. Vitamin D may help manage rheumatoid arthritis by suppressing the phosphorylation and breakdown of IkBa, and preventing the activation of NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Thunder God Vine</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The active ingredients of </span><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">thunder god vine</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Tripterygium wilfordii</span></em><span style="font-weight: 400;">) have been reported to inhibit NF-kB and other inflammatory proteins [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32323812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 clinical trials, thunder god vine extract (60-360 mg/day) improved joint inflammation and </span><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> from rheumatoid arthritis. It was more effective than the anti-rheumatic drug sulfasalazine in another study [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2509153"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12124856"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similarly, its tincture applied to the skin improved rheumatoid arthritis in a small trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12610802"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Thunder god vine and its active components also improved arthritis in multiple animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9716258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22884304"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9778100"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16983598"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16399624"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18782267"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17097618"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17354165"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18952137"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25456434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25529994"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23183089"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Thunder god vine may help manage rheumatoid arthritis by suppressing NF-kB.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Stinging Nettle</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/stinging-nettle/"><span style="font-weight: 400;">Stinging nettle</span></a><span style="font-weight: 400;"> contains anti-inflammatory compounds that may improve pain and swelling in rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529973/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The arthritis-relieving properties may be due to stinging nettle&rsquo;s ability to block NF-kB. In one study, stinging nettle was found to prevent NF-kB activation by inhibiting the breakdown of IkBa [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308835/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9923611/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Stinging nettle is often used by traditional practitioners to improve arthritis symptoms. </span><em><span style="font-weight: 400;">Urtication</span></em><span style="font-weight: 400;">, also known as &lsquo;flogging with nettles,&rsquo; is a technique where users apply raw, unprocessed stinging nettle leaves or stems to the body to generate inflammation. This has been used since Ancient Roman times for relieving chronic rheumatism, but researchers have only just begun to investigate its effectiveness [</span><a href="http://www.bmj.com/rapid-response/2011/10/27/alternative-treatment-joint-pains-stinging-nettle"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Note that we do not recommend touching a wild stinging nettle with your bare hands -- the sharp &ldquo;hairs&rdquo; on the nettle&rsquo;s surface will likely cause a red, lumpy rash. In addition, some people may experience an allergic reaction to raw pur&eacute;ed nettle or nettle juice [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">One of the active compounds found in stinging nettle is </span><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">quercetin</span></a><span style="font-weight: 400;">. Quercetin was reported to reduce some inflammatory markers and symptoms of rheumatoid arthritis (such as joint stiffness and pain) in one randomized controlled trial, but did not have any effect on inflammation and related symptoms in another trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11156742"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24829713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27710596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Stinging nettle may help manage rheumatoid arthritis by inhibiting the breakdown of IkBa and preventing NF-kB activation.&nbsp;</span></p> <h4 style="text-align: justify;"><strong><em>Boswellia serrata</em></strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/boswellia/"><em><span style="font-weight: 400;">Boswellia</span></em></a><em><span style="font-weight: 400;"> serrata</span></em><span style="font-weight: 400;"> (Indian frankincense) may suppress the production of NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25955295/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30466633/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27346540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a meta-analysis of patients with rheumatoid arthritis, 400 mg of </span><em><span style="font-weight: 400;">Boswellia</span></em><em><span style="font-weight: 400;"> serrata</span></em><span style="font-weight: 400;">&nbsp;extract reduced swelling, pain, and stiffness. Patients were also able to reduce painkiller intake and required fewer emergency treatments [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23194870"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Note that boswellic acids may only become detectable in the blood when administered with a high-fat meal [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15643550"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>Boswellia serrata</em> may help manage rheumatoid arthritis by suppressing NF-kB.&nbsp;</span></p>
511 | content_snp_table_8649156573196042_key == 8649156573196042
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511 | content_learn_more_3085206629646486_text == Based on the variants we looked at, your DRAIC gene makes you somewhat more likely to develop rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Getting moderate sun exposure and taking thunder god vine, stinging nettle, and Boswellia serrata supplements may help. Keep scrolling to find out more.
511 | content_recommendation_2243417236474791_key == 2243417236474791
511 | content_recommendation_2243417236474791_blur == True
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rsIDs = rs8026898
rsStatus = rs8026898,,chr15,69699078,G,A,,,19,16,HET
