515 | id == 515
515 | category_id == 28
515 | category_order == 25
515 | category_name == Joint Inflammation
515 | category_color == #C47AC0
515 | slug == IKZF3-Th17-rheumatoid-arthritis
515 | title == Is This Gene Worsening Your Joint Health? (IKZF3)
515 | meta_description == The IKZF3 gene stimulates the development of Th17 immune cells. Click to learn about its link with rheumatoid arthritis.
515 | summary == <p><strong>Chances are you haven&rsquo;t heard of the <em>IKZF3</em> gene; yet, it can significantly affect joint inflammation and your chances of developing rheumatoid arthritis. Read this post to learn the details and get gene-based tips.</strong></p>
515 | overall_score_text == Your Rheumatoid Arthritis Score (based on IKZF3 gene)
515 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ZPBP2-IKZF3-PGAP3-Rheumatoid-arthritis.jpg
515 | author_id == 9
515 | author_name == Aleksa Ristic
515 | author_title == MS (Pharmacy)
515 | author_order == 45
515 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
515 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
515 | reviewer == None
515 | medical_reviewer_id == 11
515 | medical_reviewer_name == Puya Yazdi
515 | medical_reviewer_title == MD
515 | publish_date == 2020
515 | publish_date == 11
515 | publish_date == 30
515 | avg_rating == 5.0
515 | tags_id == 33
515 | tags_name == Autoimmunity
515 | tags_id == 1000
515 | tags_name == IKZF3 gene
515 | tags_id == 24
515 | tags_name == Inflammation
515 | tags_id == 82
515 | tags_name == Rheumatoid Arthritis
515 | tags_id == 440
515 | tags_name == Th17 Cells
515 | permissions_favorite == False
515 | permissions_rate == False
515 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The IKZF3 gene stimulates the development of Th17 cells, which are involved in inflammation and autoimmunity.<br /><br /></strong><strong>Specific gene variants may increase IKZF3 activity; they&rsquo;ve been associated with higher rates of rheumatoid arthritis.<br /><br /></strong><strong>This post reveals potential ways to boost joint health by targeting your gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of IKZF3 in Rheumatoid Arthritis</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ikzf3/"><span style="font-weight: 400;">IKZF3</span></a><span style="font-weight: 400;"> gene stimulates the development of </span><a href="https://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17</span></a><span style="font-weight: 400;"> cells, a type of white blood cells involved in inflammation and autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22751139/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/22806"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variants in this gene can alter the levels of the main Th17 inflammatory protein, IL-17. Elevated IL-17 can contribute to rheumatoid arthritis and other autoimmune conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21546069/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106028/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811488/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576924/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In line with this, mice lacking the IKZF3 gene are protected against autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12574333/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your IKZF3 Results for Rheumatoid Arthritis</strong></h2> <p>*6960526321434943*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs2872507/"><strong>rs2872507</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/20453842"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely increases IKZF3 activity and IL-17 levels</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs12936409/"><strong>rs12936409</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher rates of rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with rheumatoid arthritis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely increases IKZF3 activity and IL-17 levels</span></li> </ul> <p><span style="font-weight: 400;">Note: these variants belong to a group of genes including </span><a href="https://selfdecode.com/gene/ikzf3/"><em><span style="font-weight: 400;">IKZF3</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="https://selfdecode.com/gene/ormdl3/"><em><span style="font-weight: 400;">ORMDL3</span></em></a><em><span style="font-weight: 400;">, </span></em><a href="https://selfdecode.com/gene/zpbp2/"><em><span style="font-weight: 400;">ZPBP2</span></em></a><em><span style="font-weight: 400;">, and </span></em><a href="https://selfdecode.com/gene/gsdmb/"><em><span style="font-weight: 400;">GSDMB</span></em></a><span style="font-weight: 400;">. Scientists are still investigating the exact gene associated with rheumatoid arthritis.</span></p> <p>*8940973909335503*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Boost Joint Health</strong></h2> <p>*9247354855064889*</p> <h3><strong>Mediterranean Diet&nbsp;</strong></h3> <p><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet, associated with lower IL-17 levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29980401/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29969908/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721241/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study, rheumatoid arthritis patients following the Mediterranean diet had significantly higher quality of life and mobility than those following a typical western diet [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23975674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The anti-inflammatory effects of the Mediterranean partly stem from its high </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> content. In fact, people who consume plenty of olive oil are much less likely to develop rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10584053/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1771399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Practice the Mediterranean diet to lessen the impact of your IKZF3 variants on joint health.</span></p> <h3><strong>Borage Oil</strong></h3> <p><span style="font-weight: 400;">A combination of </span><a href="https://www.selfhacked.com/blog/borage/"><span style="font-weight: 400;">borage oil</span></a><span style="font-weight: 400;"> and fish oil reduced IL-17 and other markers of inflammation in one clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Borage oil is rich in gamma-linolenic acid (GLA), which has anti-inflammatory effects and protects the joints. In two trials, taking borage oil capsules reduced the symptoms of rheumatoid arthritis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8214997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977504/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Borage oil may improve joint inflammation and reduce the need for anti-inflammatory drugs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10617996/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/2171540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9732298/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Borage oil may improve rheumatoid arthritis by targeting your gene variants.</span></p> <h3><strong>Whole-Body Cryotherapy</strong></h3> <p><span style="font-weight: 400;">Therapeutic </span><a href="https://selfhacked.com/blog/12-reasons-embrace-cold/"><span style="font-weight: 400;">cold</span></a><span style="font-weight: 400;"> application (cryotherapy) may improve arthritis by reducing IL-17 and other inflammatory proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536266/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41598-019-50958-8"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/whole-body-cryotherapy/"><span style="font-weight: 400;">Whole-body cryotherapy</span></a><span style="font-weight: 400;"> (WBC) involves immersing the body in an extremely cold chamber (-110℃ to -160 ℃) for 2-4 minutes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20524715"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27712663"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In three studies of 168 rheumatoid arthritis patients, WBC brought significant improvements in [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26853597"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16870097"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26576422"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Pain reduction</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Functionality</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Wellbeing</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Disease activity</span></li> </ul> <p><span style="font-weight: 400;">WBC helped with different joint disorders in three more clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28115779"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18548207"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19337708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Whole-body cryotherapy may improve rheumatoid arthritis by targeting your gene variants.</span></p>
515 | content_snp_table_6960526321434943_key == 6960526321434943
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515 | content_learn_more_8940973909335503_key == 8940973909335503
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515 | content_learn_more_8940973909335503_text == Based on the variants we looked at, your IKZF3 gene is associated with slightly higher odds of rheumatoid arthritis. However, this doesn't necessarily reflect your overall risk of rheumatoid arthritis; it’s just one gene related to it. Practice the Mediterranean diet and consider supplementing with borage oil to improve joint health by targeting your variants. Keep reading to learn more.
515 | content_recommendation_9247354855064889_key == 9247354855064889
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515 | content_recommendation_9247354855064889_hidden == False
rsIDs = rs2872507,rs12936409
rsStatus = rs2872507,,chr17,39884510,G,A,T,,31,0,Normal
rsStatus = rs12936409,,chr17,39887396,C,T,,,33,0,Normal
