516 | id == 516
516 | category_id == 29
516 | category_order == 26
516 | category_name == Lupus
516 | category_color == #C47AC0
516 | slug == JAZF1-lupus
516 | title == How Does Fat & Sugar Metabolism Affect Lupus? (JAZF1)
516 | meta_description == JAZF1 regulates sugar & fat metabolism and decreases the activity of white blood cells in fat tissue. What is its role in lupus?
516 | summary == <p><strong><em>JAZF1 </em>regulates sugar &amp; fat metabolism and decreases the activity of white blood cells in fat tissue. What is its role in lupus? Read on to learn more.</strong></p>
516 | overall_score_text == Your Lupus Score (based on JAZF1)
516 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/JAZF1-Lupus.jpg
516 | author_id == 1
516 | author_name == Jasmine Foster
516 | author_title == BSc, BEd
516 | author_order == 36
516 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
516 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
516 | reviewer == None
516 | medical_reviewer_id == 11
516 | medical_reviewer_name == Puya Yazdi
516 | medical_reviewer_title == MD
516 | publish_date == 2020
516 | publish_date == 11
516 | publish_date == 30
516 | avg_rating == 5.0
516 | tags_id == 33
516 | tags_name == Autoimmunity
516 | tags_id == 801
516 | tags_name == Blood Sugar
516 | tags_id == 570
516 | tags_name == Fat Metabolism
516 | tags_id == 829
516 | tags_name == Glucose
516 | tags_id == 95
516 | tags_name == Immune System
516 | tags_id == 24
516 | tags_name == Inflammation
516 | tags_id == 1001
516 | tags_name == JAZF1 Gene
516 | tags_id == 84
516 | tags_name == Lupus
516 | tags_id == 649
516 | tags_name == Macrophages
516 | permissions_favorite == False
516 | permissions_rate == False
516 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">JAZF1 </span></em><span style="font-weight: 400;">encodes a protein called juxtaposed with another zinc finger gene 1. Variants of </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> may play a role in lupus by increasing the activity of white blood cells in fatty tissue. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by supporting or increasing JAZF1 function.</span></p> <h2><strong><em>JAZF1 </em></strong><strong>and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/JAZF1/"><em><span style="font-weight: 400;">JAZF1</span></em></a> <span style="font-weight: 400;">gene encodes a protein called juxtaposed with another </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> finger gene 1. This protein prevents the expression of certain other genes. It also regulates blood sugar by activating visfatin, a protein that increases </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/221895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.metabolismjournal.com/article/S0026-0495(14)00146-2/abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30838734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variation in the </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> gene has been linked to cancer, diabetes, and autoimmune diseases&mdash;systemic lupus erythematosus (often simply called lupus) in particular [</span><a href="https://www.ncbi.nlm.nih.gov/gene/221895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30838734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">JAZF1 helps regulate fats (</span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">) in the bloodstream. In animals, high levels of JAZF1 activity protect against liver dysfunction from high levels of fats in the blood [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The JAZF1 protein suppresses the activity of macrophages (a type of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;">) and decreases inflammation in fatty tissues. Any genetic variant that decreases JAZF1 activity may allow for increased macrophage activity and inflammation. In turn, increased macrophage activity is common in patients with lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> encodes a zinc finger protein that regulates fat metabolism and reduces inflammation and macrophage activity in fat tissues. Low-expression variants are associated with lupus.</span></span></p> <h2><strong>Your </strong><strong><em>JAZF1</em></strong><strong> Results for Lupus</strong></h2> <p>*6616722281056528*</p> <p><a href="https://selfdecode.com/gene/JAZF1/"><strong>JAZF1</strong></a> <a href="https://selfdecode.com/snp/rs1635852/"><strong>rs1635852</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may reduce blood fat, macrophage activity, and inflammation, leading to reduced risk of lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/JAZF1/"><strong>JAZF1</strong></a> <a href="https://selfdecode.com/snp/rs849142/"><strong>rs849142</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may reduce blood fat, macrophage activity, and inflammation, leading to reduced risk of lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/JAZF1/"><strong>JAZF1</strong></a> <a href="https://selfdecode.com/snp/rs702814/"><strong>rs702814</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may reduce blood fat, macrophage activity, and inflammation, leading to reduced risk of lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/JAZF1/"><strong>JAZF1</strong></a> <a href="https://selfdecode.com/snp/rs10245867/"><strong>rs10245867</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower rate of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may reduce blood fat, macrophage activity, and inflammation, leading to reduced risk of lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*5386617388762924*</p> <h2><strong>Recommendations for Reducing Autoimmune Inflammation</strong></h2> <p>*5409920557125829*</p> <h3><strong>Blood Fat-Lowering Diet</strong></h3> <p><span style="font-weight: 400;">Animals with higher </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> expression were less likely to develop liver dysfunction from high levels of fats in the blood. JAZF1 may improve the body&rsquo;s ability to process and store fats; thus, people with low-expression </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> variants may benefit from a diet that decreases blood fat levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lupus tend to have high blood </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">, leading to increased risk of premature heart disease. In 4 controlled trials on 154 people with lupus, dietary interventions modestly improved blood fat levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7783060/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12375321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14705221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29320971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Blood fats are typically high in people with lupus, leading to potential complications. People with low-expression </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> variants may be especially prone to high blood fats.</span></span></p> <h3><strong>Reduced Carb Intake</strong></h3> <p><span style="font-weight: 400;">High concentrations of </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> have been found to reduce </span><em><span style="font-weight: 400;">JAZF1 </span></em><span style="font-weight: 400;">expression in cells of the liver and pancreas [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23442068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a small non-placebo-controlled trial on 23 women with lupus, both a low-calorie and a low-glycemic-index diet were equally effective at reducing fatigue [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22311939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">High carbohydrate intake increases blood glucose, which may reduce </span><em><span style="font-weight: 400;">JAZF1</span></em><span style="font-weight: 400;"> expression. Low carb diets, meanwhile, may improve some symptoms of lupus.</span></span></p> <h3><strong>Zinc</strong></h3> <p><span style="font-weight: 400;">JAZF1 is a zinc finger protein, meaning that it needs zinc in order to function correctly [</span><a href="https://www.ncbi.nlm.nih.gov/gene/221895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with autoimmune diseases, including lupus, are more likely to have a zinc deficiency than the healthy population. In animals, zinc deprivation worsened the symptoms of autoimmune diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6982939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Zinc is available as a supplement; the richest dietary sources include beef, pork, oysters, and other seafood [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">JAZF1 requires zinc in order to function properly, and people with autoimmune diseases are more likely to be deficient in zinc than healthy people.</span></p>
516 | content_snp_table_6616722281056528_key == 6616722281056528
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516 | content_snp_table_6616722281056528_hidden == False
516 | content_learn_more_5386617388762924_key == 5386617388762924
516 | content_learn_more_5386617388762924_blur == True
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516 | content_learn_more_5386617388762924_text == Based on the variants we looked at, your JAZF1 gene is somewhat associated with systemic lupus erythematosus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Lowering blood fats, reducing carb intake, and increasing zinc intake may help. Keep scrolling to find out more.
516 | content_recommendation_5409920557125829_key == 5409920557125829
516 | content_recommendation_5409920557125829_blur == True
516 | content_recommendation_5409920557125829_hidden == False
rsIDs = rs10245867,rs1635852,rs849142,rs702814
rsStatus = rs10245867,JAZF1,chr7,28102567,G,A,C,T,35,0,Normal
rsStatus = rs1635852,JAZF1,chr7,28149792,T,A,C,,33,0,Normal
rsStatus = rs849142,JAZF1,chr7,28146272,T,A,C,,30,0,Normal
rsStatus = rs702814,JAZF1,chr7,28133113,C,G,T,,37,0,Normal
