517 | id == 517
517 | category_id == 29
517 | category_order == 26
517 | category_name == Lupus
517 | category_color == #C47AC0
517 | slug == FCGR2B-lupus
517 | title == Immune Response Regulation in Lupus (FCGR2B)
517 | meta_description == FCGR2B helps regulate immune responses. Variants of FCGR2B have been associated with lupus. Read more here.
517 | summary == <p style="text-align:justify"><strong><em>FCGR2B</em> codes for a protein that may be involved in preventing overactive immune responses. How might variants of <em>FCGR2B</em> increase the odds of lupus? Read more to find out.</strong><br />  &nbsp;</p>
517 | overall_score_text == Your Lupus Score (based on FCGR2B gene)
517 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FCGR2B-Lupus.jpg
517 | author_id == 14
517 | author_name == Shany Lahan
517 | author_title == MS (Neuroscience)
517 | author_order == 5
517 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
517 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
517 | reviewer == None
517 | medical_reviewer_id == 11
517 | medical_reviewer_name == Puya Yazdi
517 | medical_reviewer_title == MD
517 | publish_date == 2020
517 | publish_date == 12
517 | publish_date == 1
517 | avg_rating == 5.0
517 | tags_id == 926
517 | tags_name == Autoantibodies
517 | tags_id == 33
517 | tags_name == Autoimmunity
517 | tags_id == 242
517 | tags_name == B cells
517 | tags_id == 1002
517 | tags_name == FCGR2B Gene
517 | tags_id == 24
517 | tags_name == Inflammation
517 | permissions_favorite == False
517 | permissions_rate == False
517 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">FCGR2B</span></em><span style="font-weight: 400;"> gene codes for Fc gamma receptor IIb, a protein that helps regulate immune responses. Variants of </span><em><span style="font-weight: 400;">FCGR2B </span></em><span style="font-weight: 400;">may play a role in lupus by lowering the amount of Fc gamma receptor IIb found on immune cells. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing the production or activity of Fc gamma receptor IIb.</span></span></p> <h2 style="text-align: justify;"><strong><em>FCGR2B</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/fcgr2b/"><em><span style="font-weight: 400;">FCGR2B</span></em></a> <span style="font-weight: 400;">gene codes for Fc fragment of IgG receptor IIb (Fc gamma receptor IIb), a receptor that suppresses the activity of various immune cells and thus regulates immune responses [</span><a href="https://www.ncbi.nlm.nih.gov/gene/2213"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11021804/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, Fc gamma receptor IIb can be found on the surfaces of B cells. B cells play essential roles in the production and release of antibodies, including those that mistakenly target parts of the body (autoantibodies) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11021804/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Notably, Fc gamma receptor IIb may also function to inhibit the release of inflammatory proteins, as well as control the growth and expansion (proliferation) of immune cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11021804/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Mice that lack Fc gamma receptor IIb have been reported to develop autoantibodies and symptoms characteristic of the autoimmune disorder lupus [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10981970/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8552190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10704418/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">FCGR2B </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may lower the amount of Fc gamma receptor IIb found on immune cells, resulting in dysregulated immune responses [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824439/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15681388/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>FCGR2B</em></strong><strong> Results for Lupus</strong></h2> <p style="text-align: justify;">*8492611629320912*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>FCGR2B </em></strong><a href="https://selfdecode.com/snp/rs1801274/"><strong>rs1801274</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>FCGR2B </em></strong><a href="https://selfdecode.com/snp/rs12129787/"><strong>rs12129787</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;"><strong><em>FCGR2B </em></strong><a href="https://selfdecode.com/snp/rs6671847/"><strong>rs6671847</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of lupus&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with lupus&nbsp;</span></li> </ul> <p style="text-align: justify;">*4326708840014766*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*1121334144129526*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Blood Fat-Lowering Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In mice fed a </span><a href="https://selfhack.com/blog/saturatedfats-low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">diet high in saturated fat</span></a><span style="font-weight: 400;">, Fc gamma receptor IIb production decreased significantly -- in as little as 3 days. This suggests that avoiding saturated fat may prevent a decrease in the production of Fc gamma receptor IIb [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18042831/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with lupus tend to have high blood </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">, leading to increased risk of premature heart disease. In 4 controlled trials of people with lupus, dietary interventions modestly improved blood fat levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7783060/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12375321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14705221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29320971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Eating a blood fat-lowering diet (for example, limiting the intake of saturated fats) may help manage lupus by preventing a decrease in the production of Fc gamma receptor IIb.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Zinc</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The activity of Fc gamma receptor IIb may be dependent on </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22553781/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with autoimmune disorders, including lupus, are more likely to have a zinc deficiency than the healthy population. In animals, zinc deprivation worsened symptoms of autoimmune disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6982939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Zinc is available as a supplement and is found in some foods. The richest dietary sources of zinc include beef, pork, oysters, and other seafood [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc may help manage lupus by promoting the activity of Fc gamma receptor IIb.</span></p>
517 | content_snp_table_8492611629320912_key == 8492611629320912
517 | content_snp_table_8492611629320912_blur == True
517 | content_snp_table_8492611629320912_hidden == False
517 | content_learn_more_4326708840014766_key == 4326708840014766
517 | content_learn_more_4326708840014766_blur == True
517 | content_learn_more_4326708840014766_hidden == False
517 | content_learn_more_4326708840014766_text == Based on the variants we looked at, your FCGR2B gene makes you somewhat more likely to develop lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Adhering to a blood fat-lowering diet and taking zinc supplements may help. Keep scrolling to find out more.
517 | content_recommendation_1121334144129526_key == 1121334144129526
517 | content_recommendation_1121334144129526_blur == True
517 | content_recommendation_1121334144129526_hidden == False
rsIDs = rs6671847,rs12129787,rs1801274
rsStatus = rs6671847,FCGR2A,chr1,161509020,G,A,,,10,14,HET
rsStatus = rs12129787,FCGR2A,chr1,161522797,C,T,,,11,22,HET
rsStatus = rs1801274,FCGR2A,chr1,161509955,A,C,G,,22,0,Normal
