518 | id == 518
518 | category_id == 29
518 | category_order == 26
518 | category_name == Lupus
518 | category_color == #C47AC0
518 | slug == ICAM3-lupus
518 | title == Connecting Cytokines & White Blood Cell Activity in Lupus (ICAM3)
518 | meta_description == The ICAM3 gene influences the activity of white blood cells and the production of cytokines. What is its link to lupus?
518 | summary == <p><strong>The <em>ICAM3 </em>gene influences the activity of white blood cells and the production of cytokines. What is its link to lupus? Read on to learn more.</strong></p>
518 | overall_score_text == Your Lupus Score (based on ICAM3)
518 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ICAM3-ICAM5-TYK2-Lupus.jpg
518 | author_id == 1
518 | author_name == Jasmine Foster
518 | author_title == BSc, BEd
518 | author_order == 36
518 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
518 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
518 | reviewer == None
518 | medical_reviewer_id == 11
518 | medical_reviewer_name == Puya Yazdi
518 | medical_reviewer_title == MD
518 | publish_date == 2020
518 | publish_date == 12
518 | publish_date == 1
518 | avg_rating == 5.0
518 | tags_id == 33
518 | tags_name == Autoimmunity
518 | tags_id == 96
518 | tags_name == Cytokines
518 | tags_id == 1003
518 | tags_name == ICAM3 Gene
518 | tags_id == 426
518 | tags_name == IL-12
518 | tags_id == 402
518 | tags_name == IL-23
518 | tags_id == 95
518 | tags_name == Immune System
518 | tags_id == 84
518 | tags_name == Lupus
518 | tags_id == 975
518 | tags_name == TYK2 Gene
518 | permissions_favorite == False
518 | permissions_rate == False
518 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ICAM3 </span></em><span style="font-weight: 400;">encodes intercellular adhesion molecule 3. Variants of </span><em><span style="font-weight: 400;">ICAM3</span></em><span style="font-weight: 400;"> may play a role in lupus by increasing white blood cell activity and cytokine production. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by suppressing certain cytokines.</span></p> <h2><strong><em>ICAM3</em></strong><strong> and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/icam3/"><em><span style="font-weight: 400;">ICAM3</span></em></a> <span style="font-weight: 400;">gene encodes an intercellular adhesion molecule (ICAM) that helps </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> stick to other tissues and move around the body. Researchers believe that, in addition to helping white blood cells move, ICAM3 sends important signals during an </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammatory</span></a><span style="font-weight: 400;"> immune response. It has also been implicated in inflammatory signalling in cancer, and it helps clear dead white blood cells from the body [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3385"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23775590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple </span><em><span style="font-weight: 400;">ICAM3</span></em><span style="font-weight: 400;"> variants have been associated with autoimmune diseases like rheumatoid arthritis and lupus [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variants in </span><em><span style="font-weight: 400;">ICAM3 </span></em><span style="font-weight: 400;">may also affect the expression of the </span><a href="https://selfdecode.com/gene/tyk2/"><em><span style="font-weight: 400;">TYK2</span></em></a> <span style="font-weight: 400;">gene. </span><em><span style="font-weight: 400;">TYK2</span></em><span style="font-weight: 400;"> encodes tyrosine kinase 2, a member of the </span><a href="https://www.selfdecode.com/gene/jak2/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">JAK</span></a><span style="font-weight: 400;"> protein family. Members of the JAK family activate STAT (&lsquo;Signal transducer and activator of transcription&rsquo;) proteins in response to cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7297"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TYK2 is believed to play a role in the antiviral immune response through the interferon pathways. Mutations that interfere with the function of TYK2 have been associated with immune deficiency [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7297"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other variants, however, may be protective against autoimmune diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605761/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490405/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ard.bmj.com/content/78/8/1062"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">ICAM3 helps white blood cells move around the body and may send inflammatory signals during an immune response. Variants in the </span><em><span style="font-weight: 400;">ICAM3</span></em><span style="font-weight: 400;"> and neighboring </span><em><span style="font-weight: 400;">TYK2</span></em><span style="font-weight: 400;"> genes are associated with lupus.</span></span></p> <h2><strong>Your </strong><strong><em>ICAM3</em></strong><strong> Results for Lupus</strong></h2> <p>*8245198964853093*</p> <p><a href="https://selfdecode.com/gene/icam3/"><strong>ICAM3</strong></a> <a href="https://selfdecode.com/snp/rs34536443/"><strong>rs34536443</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may reduce the activity of TYK2 and ICAM3 and suppress the production of inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23775590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/icam3/"><strong>ICAM3</strong></a> <a href="https://selfdecode.com/snp/rs2304256/"><strong>rs2304256</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may reduce the activity of TYK2 and ICAM3 and suppress the production of inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23775590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/icam3/"><strong>ICAM3</strong></a> <a href="https://selfdecode.com/snp/rs35251378/"><strong>rs35251378</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may reduce the activity of TYK2 and ICAM3 and suppress the production of inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23775590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*8353102550479541*</p> <h2><strong>Recommendations for Reducing Autoimmune Inflammation</strong></h2> <p>*5657306326972307*</p> <h3><strong>Vitamin D</strong></h3> <p><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> supplementation lowered IL-12 levels in some human studies but not in others. In a study on 57 people with lupus, vitamin D deficiency was associated with increased IL-23 levels. Both IL-12 and IL-23 signals rely on TYK2 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797739/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22028071"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23184900"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27927883"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People suffering from lupus have lower </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> levels and are at a higher risk of deficiency than healthy people according to several meta-analyses involving over 4,000 people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520805/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31468723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29412807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30636593/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Controlled trials of 490 lupus patients found that supplementation with vitamin D increases the blood levels of this vitamin and may reduce fatigue, but has no effect on lupus severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31331447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Note: sunlight exposure is usually recommended as the best way to get sufficient vitamin D, but&nbsp; many people with lupus are hypersensitive to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">UV</span></a><span style="font-weight: 400;"> radiation and develop skin damage in response to sunlight [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21593767/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Using highly protective, broad-spectrum sunscreens prevented injuries caused by UV radiation in 3 controlled clinical trials (one of them placebo-controlled) on 56 people with lupus. People with lupus are advised to use sun protection every time they go out [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11132128/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21167404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23171460/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with detrimental </span><em><span style="font-weight: 400;">ICAM3</span></em><span style="font-weight: 400;">/</span><em><span style="font-weight: 400;">TYK2</span></em><span style="font-weight: 400;"> variants may be more susceptible to vitamin D deficiency. To safely get sufficient vitamin D, consider supplementation and wearing appropriate protection when you go out into the sun.</span></span></p> <h3><strong>Omega-3 Fatty Acids</strong></h3> <p><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;"> fatty acids found in fatty fish, EPA and </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><span style="font-weight: 400;">, may inhibit </span><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17</span></a><span style="font-weight: 400;"> cells and lower the levels of </span><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">IL-17</span></a><span style="font-weight: 400;"> and IL-23. IL-23 signalling, in turn, relies on TYK2 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Omega-3 fats can also inhibit </span><a href="https://selfdecode.com/blog/article/stat3-psoriasis-79"><span style="font-weight: 400;">STAT3</span></a><span style="font-weight: 400;">, a downstream target of the JAK enzymes [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/23361365"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 6 clinical trials (most of them placebo-controlled) of 230 people with lupus, supplementation with 3-20 g/day </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acids for up to 6 months improved the symptoms, fatigue, quality of life, blood vessel function, blood fat profile, inflammatory markers and oxidative stress [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2186476/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15290734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17875549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7562770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, the results are mixed: omega-3 fatty acids were ineffective at improving lupus severity and kidney damage in 4 placebo-controlled trials on 181 people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8355469/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8172205/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29173690/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The richest supplemental source of omega-3 fatty acids is fish oil.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Omega-3 fatty acids may help balance the expression of cytokines associated with TYK2. Some studies suggest that omega-3 supplementation could help improve lupus symptoms.</span></p> <h3><strong>Thunder God Vine</strong></h3> <p><span style="font-weight: 400;">Celastrol, an active compound of </span><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">thunder god vine</span></a><span style="font-weight: 400;"> (Tripterygium wilfordii), may reduce the production of inflammatory cytokines including IL-12 and IL-23, which rely on TYK2 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26116162/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985506/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">Thunder god vine</span></a><span style="font-weight: 400;"> improved several cases of lupus in China. Most of the studies (a combination of case studies and non-placebo controlled trials) that support its use date back to the 80s, leaving this benefit uncertain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2791160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10680192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6800725/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6555446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18652362/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25058036/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29193402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In mice with lupus, thunder god vine increased survival and reduced kidney damage and inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/1445458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1728981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526566/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560846/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15840409/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Celastrol from thunder god vine may help regulate TYK2-associated cytokines and improved lupus symptoms in some studies.</span></p>
518 | content_snp_table_8245198964853093_key == 8245198964853093
518 | content_snp_table_8245198964853093_blur == True
518 | content_snp_table_8245198964853093_hidden == False
518 | content_learn_more_8353102550479541_key == 8353102550479541
518 | content_learn_more_8353102550479541_blur == True
518 | content_learn_more_8353102550479541_hidden == False
518 | content_learn_more_8353102550479541_text == Based on the variants we looked at, your ICAM3 gene is somewhat associated with autoimmune inflammation. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Vitamin D, omega-3 fatty acids, and thunder god vine may help. Keep scrolling to find out more.
518 | content_recommendation_5657306326972307_key == 5657306326972307
518 | content_recommendation_5657306326972307_blur == True
518 | content_recommendation_5657306326972307_hidden == False
rsIDs = rs34536443,rs2304256,rs35251378
rsStatus = rs34536443,TYK2,chr19,10352442,G,C,,,23,0,Normal
rsStatus = rs2304256,TYK2,chr19,10364976,C,A,,,23,9,HET
rsStatus = rs35251378,,chr19,10349293,G,A,T,,20,21,HET
