520 | id == 520
520 | category_id == 29
520 | category_order == 26
520 | category_name == Lupus
520 | category_color == #C47AC0
520 | slug == IL10-lupus
520 | title == Inflammatory & Anti-Inflammatory Roles of IL-10 in Lupus (IL10)
520 | meta_description == IL-10 is a generally anti-inflammatory cytokine that has both beneficial & detrimental roles in autoimmune disease.
520 | summary == <p><strong>IL-10 is a generally anti-inflammatory cytokine that has both beneficial &amp; detrimental roles in autoimmune disease. Click here to learn more.</strong></p>
520 | overall_score_text == Your Lupus Score (based on IL10)
520 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL10-FCMR-IL24-Lupus.jpg
520 | author_id == 1
520 | author_name == Jasmine Foster
520 | author_title == BSc, BEd
520 | author_order == 36
520 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
520 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
520 | reviewer == None
520 | medical_reviewer_id == 11
520 | medical_reviewer_name == Puya Yazdi
520 | medical_reviewer_title == MD
520 | publish_date == 2020
520 | publish_date == 12
520 | publish_date == 2
520 | avg_rating == 5.0
520 | tags_id == 926
520 | tags_name == Autoantibodies
520 | tags_id == 33
520 | tags_name == Autoimmunity
520 | tags_id == 242
520 | tags_name == B cells
520 | tags_id == 96
520 | tags_name == Cytokines
520 | tags_id == 446
520 | tags_name == IgG antibodies
520 | tags_id == 240
520 | tags_name == IL-10
520 | tags_id == 239
520 | tags_name == IL10 gene
520 | tags_id == 95
520 | tags_name == Immune System
520 | tags_id == 24
520 | tags_name == Inflammation
520 | tags_id == 84
520 | tags_name == Lupus
520 | permissions_favorite == False
520 | permissions_rate == False
520 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> encodes interleukin-10 (IL-10), an anti-inflammatory cytokine. Variants of </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> may play a role in lupus by disrupting B cell function and decreasing total circulating IL-10. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by supporting normal IL-10 function.</span></p> <h2><strong><em>IL10 </em></strong><strong>and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/il10/"><em><span style="font-weight: 400;">IL10</span></em></a> <span style="font-weight: 400;">gene codes for </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">interleukin-1</span></a><span style="font-weight: 400;">0 (also abbreviated as </span><a href="http://selfhacked.com/blog/il-10/"><span style="font-weight: 400;">IL-10</span></a><span style="font-weight: 400;">), a cytokine with a complex relationship with </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;">. In fact, most of the time, IL-10 is anti-inflammatory and suppresses the activity of </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> cells, </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> cells, </span><a href="https://selfhacked.com/blog/neutrophils/"><span style="font-weight: 400;">neutrophils</span></a><span style="font-weight: 400;">, macrophages, and </span><a href="http://selfhacked.com/blog/intro-natural-killer-cells-increase-decrease/"><span style="font-weight: 400;">natural killer cells</span></a><span style="font-weight: 400;"> [</span><a href="http://www.sciencedirect.com/science/article/pii/S0171298510002196"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.fasebj.org/content/20/9/1504.abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192723"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-10 has a complex relationship with autoimmunity. On the one hand, IL-10 suppresses the activity of almost all other </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> [</span><a href="http://www.sciencedirect.com/science/article/pii/S0171298510002196"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.fasebj.org/content/20/9/1504.abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192723"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, this cytokine stimulates the production of antibodies from B cells; if the antibodies being produced attack the body&rsquo;s own tissues, then an autoimmune reaction may result. Indeed, one study found that lupus patients with high IL-10 were significantly more likely to develop severe forms of the disease [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/15564665"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052569/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">But that&rsquo;s not where the complications end: a Japanese study found that people with lupus were likely to have autoantibodies that bind to IL-10. The authors suggested that IL-10 antibodies could be causing abnormal B cell activity in lupus patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440452/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The final point of complexity comes from variants in the </span><em><span style="font-weight: 400;">IL10</span></em><span style="font-weight: 400;"> gene. The alleles associated with increased lupus risk are also associated with decreased IL-10 levels [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794920/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21354456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Therefore, the recommendations section below will focus on strategies that both increase IL-10 and have been found to improve lupus in clinical trials.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">IL-10 is generally anti-inflammatory but stimulates antibody production from B cells. People with lupus may produce antibodies that bind to IL-10, leading to abnormal B cell activity and autoimmune inflammation.</span></p> <h2><strong>Your </strong><strong><em>IL10</em></strong><strong> Results for Lupus</strong></h2> <p>*4292915668961594*</p> <p><a href="https://selfdecode.com/gene/il10/"><strong>IL10</strong></a> <a href="https://selfdecode.com/snp/rs3024505/"><strong>rs3024505</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease circulating IL-10 and possibly disrupt normal B cell function [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794920/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440452/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/il10/"><strong>IL10</strong></a> <a href="https://selfdecode.com/snp/rs3024493/"><strong>rs3024493</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may decrease circulating IL-10 and possibly disrupt normal B cell function [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21354456/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440452/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*9155311821984844*</p> <h2><strong>Recommendations for Reducing Autoimmune Inflammation</strong></h2> <p>*4302483391060394*</p> <h3><strong>Avoid Cigarettes</strong></h3> <p><span style="font-weight: 400;">Some studies showed that smokers tend to have lower IL-10 levels (and higher levels of several inflammatory cytokines) in their blood and saliva [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29243879"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several meta-analyses found that the risk of lupus increases by approximately 50% in current but not in former smokers. Moreover, smoking may reduce the effectiveness of antimalarials such as hydroxychloroquine (used for skin injuries) by 50% and immunosuppressants such as belimumab (used for systemic symptoms) by 90% [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520802/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26188616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25648824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarette smokers tend to have lower IL-10 levels and are at greater risk of developing lupus.</span></p> <h3><strong>Physical Fitness</strong></h3> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> and physical fitness improve the immune response and reduce rates of illness. Physical activity can increase the level of IL-10 in the blood, which contributes to the anti-inflammatory effect of exercise. Research suggests that exercise duration stimulates IL-10 activity more than exercise intensity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30536945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20594330"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30536945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of people with lupus concluded that 12-week aerobic </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> programs may help improve fatigue, </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">, and physical fitness without worsening disease activity. People with mild lupus should begin with moderate intensity exercise for at least 20 minutes 3 days/week [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28477898/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28432856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People who are physically fit may have higher IL-10 levels, and physical exercise improved symptoms of lupus in a large meta-analysis.</span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">People who eat a Mediterranean diet&mdash;rich in fruits, vegetables, nuts, whole grains, and </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">; including more fish while cutting back on red meat and sweets&mdash;tend to have more circulating IL-10 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.frontiersin.org/articles/10.3389/fphar.2019.01366/full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Practicing a Mediterranean diet rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, fruits, vegetables, and fish, and low in red meat, sugars, and pastries reduced lupus severity and the risk of heart disease in a study of 280 people suffering from this condition [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32594173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, a large study of 173,000 women found that high-quality diets (including the Mediterranean diet) didn&rsquo;t reduce the risk of developing lupus. The study only suggested a reduced risk of lupus in those with a high intake of nuts and legumes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32936999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People who eat a Mediterranean diet tend to have higher IL-10 and may be at lower risk of developing lupus.</span></p> <h3><strong>NAC</strong></h3> <p><span style="font-weight: 400;">N-acetylcysteine (</span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">NAC</span></a><span style="font-weight: 400;">) decreases the inflammatory response by reducing the levels of pro-inflammatory cytokines and increasing those with an anti-inflammatory activity. NAC helped maintain high levels of the anti-inflammatory IL-10 even a week after exercising in 29 people. It also increased this cytokine in another trial on 50 people undergoing a liver transplantation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18708687"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19010165"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a small trial of people with lupus, supplementation with 2.4-4.8 g/day N-acetylcysteine (</span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">NAC</span></a><span style="font-weight: 400;">) reduced lupus severity, fatigue, and the overactive immune response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The same doses reduced ADHD symptoms in another placebo-controlled trial of 49 patients with lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">NAC supplementation helped maintain high IL-10 for longer periods after exercise and improved symptoms of lupus.</span></p>
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520 | content_learn_more_9155311821984844_text == Based on the variants we looked at, your IL10 gene is somewhat associated with autoimmune inflammation. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Avoiding cigarettes, increasing physical fitness, eating a Mediterranean diet, and supplementing with NAC may help. Keep scrolling to find out more.
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rsIDs = rs3024505,rs3024493
rsStatus = rs3024505,,chr1,206766559,G,A,,,17,15,HET
rsStatus = rs3024493,IL10,chr1,206770623,C,A,T,,17,17,HET
