521 | id == 521
521 | category_id == 29
521 | category_order == 26
521 | category_name == Lupus
521 | category_color == #C47AC0
521 | slug == RAD51B-lupus
521 | title == DNA Damage and Repair Mechanisms in Lupus (RAD51B)
521 | meta_description == RAD51B senses DNA damage & prevents immune cells from attacking the body’s own tissues. What is its connection to lupus?
521 | summary == <p><strong><em>RAD51B </em>helps sense DNA damage &amp; may prevent immune cells from attacking the body&rsquo;s own tissues. What is its connection to lupus?</strong></p>
521 | overall_score_text == Your Lupus Score (based on RAD51B)
521 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RAD51B-Lupus.jpg
521 | author_id == 1
521 | author_name == Jasmine Foster
521 | author_title == BSc, BEd
521 | author_order == 36
521 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
521 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
521 | reviewer == None
521 | medical_reviewer_id == 11
521 | medical_reviewer_name == Puya Yazdi
521 | medical_reviewer_title == MD
521 | publish_date == 2020
521 | publish_date == 12
521 | publish_date == 2
521 | avg_rating == 5.0
521 | tags_id == 33
521 | tags_name == Autoimmunity
521 | tags_id == 750
521 | tags_name == DNA Damage
521 | tags_id == 40
521 | tags_name == DNA Repair
521 | tags_id == 95
521 | tags_name == Immune System
521 | tags_id == 84
521 | tags_name == Lupus
521 | tags_id == 962
521 | tags_name == RAD51B Gene
521 | permissions_favorite == False
521 | permissions_rate == False
521 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">RAD51B </span></em><span style="font-weight: 400;">encodes a DNA repair protein called RAD51 paralog B. Variants of </span><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> may play a role in lupus by increasing susceptibility to DNA damage. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by promoting DNA repair.</span></p> <h2><strong><em>RAD51B</em></strong><strong> and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/rad51b/"><em><span style="font-weight: 400;">RAD51B</span></em></a> <span style="font-weight: 400;">gene encodes a DNA repair protein called RAD51 paralog B. Along with other related RAD51 proteins, RAD51B helps sense DNA damage and stops compromised cells from reproducing [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=5890"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Low levels of RAD51B may lead to compromised cells multiplying out of control, which in turn may cause the formation of tumors. Research suggests that people with higher than normal </span><em><span style="font-weight: 400;">RAD51B </span></em><span style="font-weight: 400;">expression may have better protection from cancer than those with lower RAD51B [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342748/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Through a similar protective mechanism, high RAD51B activity may prevent immune cells from attacking the body&rsquo;s own tissues, thereby suppressing autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Patients with lupus are likely to have disrupted DNA repair mechanisms, making them more susceptible to DNA damage and mutation. Variants in the </span><em><span style="font-weight: 400;">RAD51B</span></em><span style="font-weight: 400;"> gene may contribute to this disruption [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179597/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973109/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">RAD51B helps sense DNA damage and may prevent immune cells from attacking the body&rsquo;s own tissues. Variants that reduce RAD51B activity have been associated with lupus.</span></p> <h2><strong>Your </strong><strong><em>RAD51B</em></strong><strong> Results for Lupus</strong></h2> <p>*3168969877826111*</p> <p><a href="https://selfdecode.com/gene/rad51b/"><strong>RAD51B</strong></a> <a href="https://selfdecode.com/snp/rs911263/"><strong>rs911263</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase RAD51B expression, leading to lower levels of potentially damaging cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342748/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*7874184380768301*</p> <h2><strong>Recommendations for Reducing Autoimmune Inflammation</strong></h2> <p>*8619657650394497*</p> <h3><strong>Avoid Cigarettes</strong></h3> <p><span style="font-weight: 400;">Exposure to cigarette smoke is well-known to increase the rate of DNA damage and reduce DNA repair capacity. People with potentially detrimental RAD51B alleles may already have reduced DNA repair, so cigarette smoke is especially dangerous [</span><a href="https://www.pnas.org/content/115/7/E1560"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749693/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several meta-analyses found that the risk of lupus increases by approximately 50% in current but not in former smokers. Moreover, smoking may reduce the effectiveness of antimalarials such as hydroxychloroquine (used for skin injuries) by 50% and immunosuppressants such as belimumab (used for systemic symptoms) by 90% [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520802/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26188616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25648824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarette smoke exposure increases the rate of DNA damage and may worsen the effects of low RAD51B in lupus.</span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">Many active compounds found in plant-based foods have been found to increase the rate and efficiency of DNA repair mechanisms and to prevent DNA damage in the first place. These compounds are common in the Mediterranean diet, which is rich in fruits, vegetables, whole grains, and </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Practicing a Mediterranean diet rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, fruits, vegetables, and fish, and low in red meat, sugars, and pastries reduced lupus severity and the risk of heart disease in a study of 280 people suffering from this condition [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32594173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, a large study of 173,000 women found that high-quality diets (including the Mediterranean diet) didn&rsquo;t reduce the risk of developing lupus. The study only suggested a reduced risk of lupus in those with a high intake of nuts and legumes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32936999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People who eat a Mediterranean diet may be less susceptible to DNA damage. Common components of the diet&mdash;olive oil, fruits, vegetables, and fish&mdash;may improve the symptoms of lupus.</span></p> <h3><strong>NAC</strong></h3> <p><span style="font-weight: 400;">N-acetylcysteine (</span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">NAC</span></a><span style="font-weight: 400;">) prevents DNA damage and promotes DNA repair, according to a large pool of cell and animal research [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11408342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22692827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30496017/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a placebo-controlled trial of 36 people with lupus, supplementation with 2.4-4.8 g/day </span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">NAC</span></a><span style="font-weight: 400;"> reduced lupus severity, fatigue, and the overactive immune response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The same doses reduced ADHD symptoms in another placebo-controlled trial of 49 patients with lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">NAC may reduce the severity of lupus symptoms by preventing DNA damage and promoting DNA repair.</span></p>
521 | content_snp_table_3168969877826111_key == 3168969877826111
521 | content_snp_table_3168969877826111_blur == True
521 | content_snp_table_3168969877826111_hidden == False
521 | content_learn_more_7874184380768301_key == 7874184380768301
521 | content_learn_more_7874184380768301_blur == True
521 | content_learn_more_7874184380768301_hidden == False
521 | content_learn_more_7874184380768301_text == Based on the variants we looked at, your RAD51B gene is somewhat associated with disrupted DNA repair. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Avoiding cigarettes, eating a Mediterranean diet, and supplementing with NAC may help. Keep scrolling to find out more.
521 | content_recommendation_8619657650394497_key == 8619657650394497
521 | content_recommendation_8619657650394497_blur == True
521 | content_recommendation_8619657650394497_hidden == False
rsIDs = rs911263
rsStatus = rs911263,RAD51B,chr14,68286876,C,A,T,,29,0,Normal
