522 | id == 522
522 | category_id == 29
522 | category_order == 26
522 | category_name == Lupus
522 | category_color == #C47AC0
522 | slug == LBH-lupus
522 | title == A Genetic Link Between Joint Cell Expansion & Lupus (LBH)
522 | meta_description == LBH regulates joint cell expansion. Variants of LBH have been associated with lupus. Read more here.
522 | summary == <p style="text-align:justify"><strong>The <em>LBH</em> gene helps regulate the growth and expansion of cells involved in lupus progression. Read more to learn how variants of <em>LBH</em> may increase the risk of this autoimmune disorder, and how you may be able to counter their effects.&nbsp;</strong></p>
522 | overall_score_text == Your Lupus Score (based on LBH gene)
522 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/LBH-Lupus.jpg
522 | author_id == 14
522 | author_name == Shany Lahan
522 | author_title == MS (Neuroscience)
522 | author_order == 5
522 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
522 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
522 | reviewer == None
522 | medical_reviewer_id == 11
522 | medical_reviewer_name == Puya Yazdi
522 | medical_reviewer_title == MD
522 | publish_date == 2020
522 | publish_date == 12
522 | publish_date == 2
522 | avg_rating == 5.0
522 | tags_id == 939
522 | tags_name == Fibroblast-Like Synoviocytes
522 | tags_id == 24
522 | tags_name == Inflammation
522 | tags_id == 965
522 | tags_name == LBH Gene
522 | tags_id == 369
522 | tags_name == NF-κB
522 | tags_id == 941
522 | tags_name == Synovial Joint
522 | permissions_favorite == False
522 | permissions_rate == False
522 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">LBH helps regulate the growth and expansion of cells involved in joint inflammation. Variants of </span><em><span style="font-weight: 400;">LBH </span></em><span style="font-weight: 400;">may play a role in lupus by decreasing the production of LBH. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing LBH production or lowering levels of inflammatory proteins.&nbsp;</span></span></p> <h2 style="text-align: justify;"><strong><em>LBH</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/lbh/"><em><span style="font-weight: 400;">LBH</span></em></a> <span style="font-weight: 400;">gene codes for limb-bud and heart development (LBH), a protein that helps regulate the growth and expansion of a type of cell called fibroblast-like synoviocyte [</span><a href="https://www.ncbi.nlm.nih.gov/gene/81606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Fibroblast-like synoviocytes are found in the most mobile and common type of joint in the human body: the synovial joint. When dysregulated, these cells may induce the progression of lupus by releasing inflammatory proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306636/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130137/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, low levels of LBH may damage the DNA of fibroblast-like synoviocytes. DNA damage has been shown to promote the excessive expansion (proliferation) of these cells and joint inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">As LBH also suppresses </span><a href="https://selfhacked.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;">, low LBH levels may further promote inflammation by enabling NF-kB activation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23807646/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">LBH </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may decrease production of LBH, leading to dysregulated fibroblast-like synoviocyte development and joint inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26134586/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>LBH </em></strong><strong>Results for Lupus</strong></h2> <p style="text-align: justify;">*5736995402885483*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>LBH </em></strong><a href="https://selfdecode.com/snp/rs7579944/"><strong>rs7579944</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/27399966"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNP:</strong></p> <p style="text-align: justify;"><strong><em>LBH </em></strong><a href="https://selfdecode.com/snp/rs17321999/"><strong>rs17321999</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus, relative to &lsquo;A&rsquo;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of lupus, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;">*3086428188245396*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*2641785611789025*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Sun Protection</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Although a moderate exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> is the best way to increase blood </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> levels, which are often low in people with lupus, the skin of many people with this condition is hypersensitive to UV radiation and develops injuries in response to sunlight [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21593767/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, long periods of sun exposure have been reported to activate NF-kB, suggesting that it may amplify the negative effects of </span><em><span style="font-weight: 400;">LBH </span></em><span style="font-weight: 400;">risk variants. This effect was attributed to radiation from the sun&rsquo;s UV rays [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16211268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Using highly protective, broad-spectrum sunscreens prevented injuries caused by UV radiation in 3 clinical trials of patients with lupus. People with lupus are advised to use sun protection every time they go outside [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11132128/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21167404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23171460/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Using sun protection may help manage lupus by preventing the activation of NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The&nbsp; Mediterranean diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, fruits, vegetables, and fish, but is low in red meat, sugars, and pastries.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Pentanal, a compound found in olive oil, increased the production of LBH in human cells. In a randomized controlled trial, the Mediterranean diet lowered inflammation by reducing levels of NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22085595/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Practicing the Mediterranean diet reduced lupus severity and the risk of heart disease in a study of 280 people suffering from this condition [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32594173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, a large study found that high-quality diets (including the Mediterranean diet) didn&rsquo;t reduce the risk of developing lupus. The study only suggested a reduced risk of lupus in those with a high intake of nuts and legumes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32936999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage lupus by increasing the production of LBH and lowering levels of NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Supplement</strong></h3> <h4 style="text-align: justify;"><strong>Curcumin</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the main active compound of turmeric.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a cell-based study, curcumin was reported to increase the production of LBH by 16-fold [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to a preliminary randomized controlled trial of lupus patients, short-term turmeric supplementation may decrease blood and kidney damage (measured as protein in the urine) along with systolic blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21742514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin may help manage lupus by increasing the production of LBH.</span></p>
522 | content_snp_table_5736995402885483_key == 5736995402885483
522 | content_snp_table_5736995402885483_blur == True
522 | content_snp_table_5736995402885483_hidden == False
522 | content_learn_more_3086428188245396_key == 3086428188245396
522 | content_learn_more_3086428188245396_blur == True
522 | content_learn_more_3086428188245396_hidden == False
522 | content_learn_more_3086428188245396_text == Based on the variants we looked at, your LBH gene is associated with somewhat higher odds of lupus, relative to other variants. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Adhering to the Mediterranean diet, using sun protection, and taking curcumin supplements may help. Keep scrolling to find out more.
522 | content_recommendation_2641785611789025_key == 2641785611789025
522 | content_recommendation_2641785611789025_blur == True
522 | content_recommendation_2641785611789025_hidden == False
rsIDs = rs17321999,rs7579944
rsStatus = rs17321999,LBH,chr2,30256991,C,A,,,28,0,Normal
rsStatus = rs7579944,,chr2,30222160,T,C,G,,11,18,HET
