523 | id == 523
523 | category_id == 29
523 | category_order == 26
523 | category_name == Lupus
523 | category_color == #C47AC0
523 | slug == IKZF1-lupus
523 | title == Can Variants in This Gene Protect Against Lupus? (IKZF1)
523 | meta_description == The IKZF1 gene controls the activity of T-helper immune cells. Click to learn about its link with lupus.
523 | summary == <p style="text-align:justify"><strong>Did you know that your genes influence the Th1/Th2 immune balance? Read this post to learn about the link between <em>IKZF1</em> and lupus, and get gene-based tips!</strong></p>
523 | overall_score_text == Your Lupus Score (based on IKZF1 gene)
523 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IKZF1-Lupus.jpg
523 | author_id == 9
523 | author_name == Aleksa Ristic
523 | author_title == MS (Pharmacy)
523 | author_order == 45
523 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
523 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
523 | reviewer == None
523 | medical_reviewer_id == 11
523 | medical_reviewer_name == Puya Yazdi
523 | medical_reviewer_title == MD
523 | publish_date == 2020
523 | publish_date == 12
523 | publish_date == 3
523 | avg_rating == 5.0
523 | tags_id == 33
523 | tags_name == Autoimmunity
523 | tags_id == 1005
523 | tags_name == IFN-gamma
523 | tags_id == 1004
523 | tags_name == IKZF1 gene
523 | tags_id == 84
523 | tags_name == Lupus
523 | tags_id == 435
523 | tags_name == Th1 Cells
523 | permissions_favorite == False
523 | permissions_rate == False
523 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The </strong><strong><em>IKZF1</em></strong><strong> gene suppresses the immune cells that produce interferon-gamma (IFN-gamma). People with lupus tend to have increased IFN-gamma levels.<br /><br /></strong><strong>Specific gene variants are associated with lower odds of lupus. They likely increase </strong><strong><em>IKZF1</em></strong><strong> activity and reduce IFN-gamma levels.<br /><br /></strong><strong>This post reveals potential ways to improve lupus by targeting </strong><strong><em>IKZF1</em></strong><strong> variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The IKZF1 Gene and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ikzf1/"><em><span style="font-weight: 400;">IKZF1</span></em></a><span style="font-weight: 400;"> gene shifts the </span><a href="https://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/"><span style="font-weight: 400;">Th1/Th2</span></a><span style="font-weight: 400;"> balance in favor of Th2 immune cells. Since </span><a href="https://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> cells produce interferon-gamma (IFN-gamma), this shift results in lower IFN-gamma levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807311/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN-gamma</span></a><span style="font-weight: 400;"> is crucial for antimicrobial immunity but also plays a role in lupus and other autoimmune conditions. Lupus patients tend to have higher IFN-gamma levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1746015"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your IKZF1 Results for Lupus</strong></h2> <p>*1696677258688246*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs4917014/"><strong>rs4917014</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely increases IKZF1 activity and reduces IFN-gamma levels.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs11185602/"><strong>rs11185602</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely increases IKZF1 activity and reduces IFN-gamma levels.</span></li> </ul> <p>*2215929394134042*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Lupus</strong></h2> <p>*3294059381866066*</p> <h3><strong>Stress Reduction</strong></h3> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> can have detrimental effects on the immune response. One study associated stress and anxiety with elevated IFN-gamma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9617578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study, daily stress worsened performance in visual memory, visual fluency, and attention in lupus patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17211991/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Stress-management psychological interventions such as cognitive-behavioral therapy or counseling may reduce </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and lupus severity while improving quality of life. However, a meta-analysis concluded that the evidence is based on low-quality studies and requires further investigation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199565/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15334437/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20841339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22570339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid psychological stress to lessen the impact of your gene variants on lupus.</span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">In one clinical trial, a Mediterranean diet supplemented with extra virgin </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> reduced IFN-gamma levels and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Practicing a Mediterranean diet rich in olive oil may reduce lupus severity and heart disease risk [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32594173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, an extensive study of 173,000 women found that high-quality diets, including the Mediterranean diet, didn&rsquo;t reduce the risk of developing lupus. The study only suggested lower odds of lupus in those with a high intake of nuts and legumes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32936999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A Mediterranean diet rich in olive oil, nuts, and legumes may improve lupus by targeting your gene variants.</span></p> <h3><strong>Vitamin D</strong></h3> <p><span style="font-weight: 400;">People with lupus have lower </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> levels and are at a higher risk of deficiency, according to several meta-analyses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520805/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31468723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29412807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30636593/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study, lupus patients deficient in vitamin D had 150% higher IFN-gamma levels, compared with non-deficient patients and healthy controls [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972245/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D supplementation may correct a deficiency and reduce fatigue but may not improve lupus severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31331447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin D supplementation may correct vitamin D deficiency and reduce fatigue in lupus patients by targeting IKZF1 variants.</span></p>
523 | content_snp_table_1696677258688246_key == 1696677258688246
523 | content_snp_table_1696677258688246_blur == True
523 | content_snp_table_1696677258688246_hidden == False
523 | content_learn_more_2215929394134042_key == 2215929394134042
523 | content_learn_more_2215929394134042_blur == True
523 | content_learn_more_2215929394134042_hidden == False
523 | content_learn_more_2215929394134042_text == Based on the variants we looked at, your IKZF1 gene is associated with slightly lower odds of lupus. However, other genes and health factors may still contribute to your risk of lupus. Keep reading to learn more.
523 | content_recommendation_3294059381866066_key == 3294059381866066
523 | content_recommendation_3294059381866066_blur == True
523 | content_recommendation_3294059381866066_hidden == False
rsIDs = rs4917014,rs11185602
rsStatus = rs4917014,,chr7,50266267,T,C,G,,35,0,Normal
rsStatus = rs11185602,,chr7,50259481,A,C,G,,27,1,HET
