524 | id == 524
524 | category_id == 29
524 | category_order == 26
524 | category_name == Lupus
524 | category_color == #C47AC0
524 | slug == SH2B3-lupus
524 | title == The Role of an Immune Adapter Protein in Lupus (SH2B3)
524 | meta_description == SH2B3 encodes an immune system regulator that tips the balance between Th1 & Th2. What is its connection to lupus?
524 | summary == <p><strong><em>SH2B3 </em>encodes an immune system regulator that tips the balance between Th1 &amp; Th2. What is its connection to lupus? Read on to find out.</strong></p>
524 | overall_score_text == Your Lupus Score (based on SH2B3)
524 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ATXN2-SH2B3-Lupus.jpg
524 | author_id == 1
524 | author_name == Jasmine Foster
524 | author_title == BSc, BEd
524 | author_order == 36
524 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
524 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
524 | reviewer == None
524 | medical_reviewer_id == 11
524 | medical_reviewer_name == Puya Yazdi
524 | medical_reviewer_title == MD
524 | publish_date == 2020
524 | publish_date == 12
524 | publish_date == 3
524 | avg_rating == 5.0
524 | tags_id == 926
524 | tags_name == Autoantibodies
524 | tags_id == 33
524 | tags_name == Autoimmunity
524 | tags_id == 95
524 | tags_name == Immune System
524 | tags_id == 84
524 | tags_name == Lupus
524 | tags_id == 211
524 | tags_name == SH2B3 Gene
524 | tags_id == 442
524 | tags_name == T Cells
524 | tags_id == 435
524 | tags_name == Th1 Cells
524 | permissions_favorite == False
524 | permissions_rate == False
524 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> encodes an adapter protein that regulates the immune response. Variants of </span><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> may play a role in lupus by increasing Th1 cell activity and autoantibody production. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by suppressing the Th1 response.</span></p> <h2><strong><em>SH2B3</em></strong><strong> and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/sh2b3/"><em><span style="font-weight: 400;">SH2B3</span></em></a> <span style="font-weight: 400;">gene codes for SH2B adapter protein 3. This protein helps regulate an array of essential pathways, including [</span><a href="https://ghr.nlm.nih.gov/gene/SH2B3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Inflammation and the immune response</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Blood cell formation (hematopoiesis)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cell growth and migration</span></li> </ul> <p><span style="font-weight: 400;">Due to its wide range of functions, SH2B3 has considerable significance for human health. Studies have linked its variants with different autoimmune conditions, heart disease, blood disorders, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21723852"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/lookup/doi/10.1161/HYPERTENSIONAHA.115.04887"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">SH2B3 primarily regulates the function of T cells and has been associated with relative numbers of eosinophils (a type of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cell</span></a><span style="font-weight: 400;">). It may suppress </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> cell response and prevent autoimmunity by inhibiting the formation of auto-antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298800/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26535636"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some evidence suggests this gene may also be involved in fine-tuning the inflammatory response. For example, a rare human case of a genetic SH2B3 loss resulted in severe autoimmune disease, along with other developmental issues. In mice without this protein, scientists have observed over-production of inflammatory cytokines [</span><a href="https://www.jimmunol.org/content/193/4/1728.long"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/lookup/doi/10.1161/HYPERTENSIONAHA.115.04887"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because of these factors, it&rsquo;s unsurprising that </span><em><span style="font-weight: 400;">SH2B3</span></em><span style="font-weight: 400;"> has been associated with lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668589/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The SH2B3 gene appears to affect the Th1/Th2 immune system balance, and variants that tip the scale toward Th1 may increase susceptibility to autoimmune disease.</span></p> <h2><strong>Your </strong><strong><em>SH2B3</em></strong><strong> Results for Lupus</strong></h2> <p>*4314449369794615*</p> <p><a href="https://selfdecode.com/gene/sh2b3/"><strong>SH2B3</strong></a> <a href="https://selfdecode.com/snp/rs653178/"><strong>rs653178</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may promote the Th1 response and increase the production of autoantibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298800/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26535636"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/sh2b3/"><strong>SH2B3</strong></a> <a href="https://selfdecode.com/snp/rs597808/"><strong>rs597808</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may promote the Th1 response and increase the production of autoantibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298800/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26535636"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*2531256558352293*</p> <h2><strong>Recommendations for Reducing Autoimmune Inflammation</strong></h2> <p>*4124951805351020*</p> <h3><strong>Acupuncture</strong></h3> <p><span style="font-weight: 400;">According to one study, </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> may help reduce the activity of Th1 cells, which can get out of control without SH2B3 to regulate them [</span><a href="https://www.hindawi.com/journals/ecam/2012/893023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Acupuncture may help relieve the muscle </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> associated with lupus. In a small non-placebo-controlled trial on 24 lupus patients, standard care failed to reduce pain while a 10-session course of acupuncture reduced it by at least 30% in 40% of the patients who received it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633212/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may reduce the activity of Th1 cells, and some studies suggest that it may improve pain in lupus patients.</span></p> <h3><strong>Green Tea</strong></h3> <p><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;">, the most important active compound in green tea, may decrease the activity of Th1 cells. It also inhibits the production of autoantibodies in rats [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23064699"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14758719/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a placebo-controlled trial of 68 people with lupus, taking 1000 mg/day of a </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;"> extract with 22% polyphenols (equivalent to one cup of green tea) for 12 weeks improved disease severity and quality of life [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28585735/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">EGCG from green tea may decrease Th1 activity and improve disease severity in lupus.</span></p> <h3><strong>Fish Oil</strong></h3> <p><span style="font-weight: 400;">The omega-3 fatty acid </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><span style="font-weight: 400;">, which is most abundant in </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">, decreases the production of Th1 cytokines. DHA also significantly decreased autoantibody production in mice [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11261793/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 6 clinical trials (most of them placebo-controlled) of 230 people with lupus, supplementation with 3-20 g/day omega-3 fatty acids for up to 6 months improved the symptoms, fatigue, quality of life, blood vessel function, blood fat profile, inflammatory markers and oxidative stress [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2186476/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15290734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17875549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7562770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, the results are mixed: omega-3 fatty acids were ineffective at improving lupus severity and kidney damage in 4 placebo-controlled trials on 181 people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8355469/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8172205/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29173690/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">DHA, an omega-3 fatty acid abundant in fish oil, may decrease Th1 cytokines and autoantibody production. Omega-3 supplementation has produced mixed results in lupus.</span></p>
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524 | content_learn_more_2531256558352293_text == Based on the variants we looked at, your SH2B3 gene is somewhat associated with autoimmune inflammation. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Acupuncture, green tea, and fish oil may help. Keep scrolling to find out more.
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rsIDs = rs597808,rs653178
rsStatus = rs597808,ATXN2,chr12,111535554,A,C,G,T,43,0,Normal
rsStatus = rs653178,ATXN2,chr12,111569952,C,G,T,,41,0,Normal
