526 | id == 526
526 | category_id == 29
526 | category_order == 26
526 | category_name == Lupus
526 | category_color == #C47AC0
526 | slug == UBE2L3-lupus
526 | title == A Genetic Link Between Protein Modulation & Lupus (UBE2L3)
526 | meta_description == UBE2L3 helps modulate protein activity. Variants of UBE2L3 have been associated with lupus. Read more here.
526 | summary == <p style="text-align:justify"><strong>UBE2L3 may help modulate protein breakdown, location, activity, and interactions&hellip; but how might <em>UBE2L3</em> variants increase the risk of lupus? Read more to find out.</strong></p>
526 | overall_score_text == Your Lupus Score (based on UBE2L3 gene)
526 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/UBE2L3-YDLC-YDJC-Lupus.jpg
526 | author_id == 14
526 | author_name == Shany Lahan
526 | author_title == MS (Neuroscience)
526 | author_order == 5
526 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
526 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
526 | reviewer == None
526 | medical_reviewer_id == 11
526 | medical_reviewer_name == Puya Yazdi
526 | medical_reviewer_title == MD
526 | publish_date == 2020
526 | publish_date == 12
526 | publish_date == 3
526 | avg_rating == 5.0
526 | tags_id == 926
526 | tags_name == Autoantibodies
526 | tags_id == 33
526 | tags_name == Autoimmunity
526 | tags_id == 24
526 | tags_name == Inflammation
526 | tags_id == 369
526 | tags_name == NF-κB
526 | tags_id == 959
526 | tags_name == UBE2L3 Gene
526 | tags_id == 841
526 | tags_name == Ubiquitin
526 | tags_id == 843
526 | tags_name == Ubiquitination
526 | permissions_favorite == False
526 | permissions_rate == False
526 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">UBE2L3 </span></em><span style="font-weight: 400;">gene encodes ubiquitin-conjugating enzyme E2 L3, an enzyme involved in modulating the activity of the inflammatory protein NF-kB. Variants of </span><em><span style="font-weight: 400;">UBE2L3 </span></em><span style="font-weight: 400;">may play a role in lupus by increasing the production or activity of ubiquitin-conjugating enzyme E2 L3. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing ubiquitin-conjugating enzyme E2 L3, or suppressing NF-kB.</span></span></p> <h2 style="text-align: justify;"><strong><em>UBE2L3</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ube2l3/"><em><span style="font-weight: 400;">UBE2L3</span></em></a> <span style="font-weight: 400;">gene codes for ubiquitin-conjugating enzyme E2 L3. This enzyme is involved in </span><em><span style="font-weight: 400;">ubiquitination</span></em><span style="font-weight: 400;">: the attachment of a ubiquitin molecule to proteins [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7332"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ubiquitin targets abnormal proteins for breakdown, and may be involved in altering the interactions, location, or activity of proteins, such as </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7923371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32334614/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945881/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB has been shown to stimulate the release of inflammatory proteins, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">UBE2L3 </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may increase the production or activity of ubiquitin-conjugating enzyme E2 L3, which may lead to excess production of NF-kB, inflammatory protein release, and autoantibody formation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945881/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>UBE2L3</em></strong><strong> Results for Lupus</strong></h2> <p style="text-align: justify;">*2328823426313908*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>UBE2L3 </em></strong><a href="https://selfdecode.com/snp/rs131654/"><strong>rs131654</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of lupus&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>UBE2L3 </em></strong><a href="https://selfdecode.com/snp/rs7444/"><strong>rs7444</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;"><strong><em>UBE2L3 </em></strong><a href="https://selfdecode.com/snp/rs3747093/"><strong>rs3747093</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of lupus</span><span style="font-weight: 400;">&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;">*6789200291518571*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">*3004202782061034*</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Cigarettes</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In human lung cells, exposure to cigarette smoke increased the production of ubiquitin-conjugating enzyme E2 L3 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30291989/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Cigarette smoke has also been shown to activate NF-kB in numerous studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27586697/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18091336/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22724137/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Several meta-analyses found that the risk of lupus increases by approximately 50% in current but not in former smokers. Moreover, smoking may reduce the effectiveness of antimalarials such as hydroxychloroquine (used for skin injuries) by 50% and immunosuppressants such as belimumab (used for systemic symptoms) by 90% [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520802/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26188616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25648824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarette smoke may increase the production of ubiquitin-conjugating enzyme E2 L3 and NF-kB. Avoiding cigarette smoke may help manage lupus by preventing an increase in these proteins.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Flaxseed</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple animal-based studies demonstrated that </span><a href="https://selfhacked.com/blog/flaxseed-oil-benefits/"><span style="font-weight: 400;">flaxseed</span></a><span style="font-weight: 400;"> oil or its primary polyphenol may suppress NF-kB [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394576/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27048415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 small trials of people with lupus and kidney damage, taking 30 g of ground flaxseed daily improved kidney function while reducing inflammatory and artery-clogging markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7564115/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11349937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Flaxseed may help manage lupus by suppressing NF-kB.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>N-Acetylcysteine</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">A number of studies have shown that </span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">N-acetylcysteine</span></a><span style="font-weight: 400;"> (</span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">NAC</span></a><span style="font-weight: 400;">) may suppress NF-kB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10788610/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/14605526/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/23242830/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a trial of people with lupus, supplementation with 2.4-4.8g/day of NAC reduced lupus severity, fatigue, and an overactive immune response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The same doses reduced ADHD symptoms in another trial of lupus patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">N-acetylcysteine may help manage lupus by suppressing NF-kB.</span></p> <h4 style="text-align: justify;"><strong>Pine Bark Extract (Pycnogenol)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Standardized </span><a href="https://selfhacked.com/blog/pycnogenol-pine-bark-extract-health-benefits/"><span style="font-weight: 400;">maritime pine bark extract</span></a><span style="font-weight: 400;"> (Pycnogenol) prevented the activation of NF-kB in a number of studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 2 trials of patients with lupus, Pycnogenol reduced symptoms, inflammation, and </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;"> at least as effectively as standard care [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11746863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32429631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Maritime pine may help manage lupus by preventing NF-kB activation. </span></p>
526 | content_snp_table_2328823426313908_key == 2328823426313908
526 | content_snp_table_2328823426313908_blur == True
526 | content_snp_table_2328823426313908_hidden == False
526 | content_learn_more_6789200291518571_key == 6789200291518571
526 | content_learn_more_6789200291518571_blur == True
526 | content_learn_more_6789200291518571_hidden == False
526 | content_learn_more_6789200291518571_text == Based on the variants we looked at, your UBE2L3 gene makes you somewhat more likely to develop lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Avoiding cigarettes, consuming flaxseed, taking N-acetylcysteine supplements, and taking pine bark extract (Pycnogenol) supplements may help. Keep scrolling to find out more.
526 | content_recommendation_3004202782061034_key == 3004202782061034
526 | content_recommendation_3004202782061034_blur == True
526 | content_recommendation_3004202782061034_hidden == False
rsIDs = rs131654,rs3747093,rs7444
rsStatus = rs131654,UBE2L3,chr22,21562901,G,A,T,,33,0,Normal
rsStatus = rs3747093,YDJC,chr22,21630090,G,A,,,22,0,Normal
rsStatus = rs7444,UBE2L3,chr22,21622645,T,C,,,29,0,Normal
