528 | id == 528
528 | category_id == 29
528 | category_order == 26
528 | category_name == Lupus
528 | category_color == #C47AC0
528 | slug == MICB-HLA-lupus
528 | title == Strong Genetic Factor for Autoimmunity in Lupus (MICB)
528 | meta_description == The MICB gene belongs to the HLA group, highly involved in autoimmunity. Learn about its association with lupus.
528 | summary == <p style="text-align:justify"><strong>The MICB gene has one of the strongest known associations with lupus! Read this post to learn the details and get gene-based recommendations.</strong></p>
528 | overall_score_text == Your Lupus Score (based on MICB gene)
528 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HLA-DRA-MICB-Lupus.jpg
528 | author_id == 9
528 | author_name == Aleksa Ristic
528 | author_title == MS (Pharmacy)
528 | author_order == 45
528 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
528 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
528 | reviewer == None
528 | medical_reviewer_id == 11
528 | medical_reviewer_name == Puya Yazdi
528 | medical_reviewer_title == MD
528 | publish_date == 2020
528 | publish_date == 12
528 | publish_date == 4
528 | avg_rating == 5.0
528 | tags_id == 33
528 | tags_name == Autoimmunity
528 | tags_id == 422
528 | tags_name == HLA complex
528 | tags_id == 84
528 | tags_name == Lupus
528 | tags_id == 883
528 | tags_name == MICB Gene
528 | permissions_favorite == False
528 | permissions_rate == False
528 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong><em>MICB</em></strong><strong> belongs to the MHC or HLA group of genes, highly involved in lupus and other autoimmune conditions.<br /><br /></strong><strong>Specific gene variants may increase or alter MICB activity. They&rsquo;ve been associated with higher odds of lupus.<br /><br /></strong><strong>Read this post to discover the potential ways to prevent and improve lupus by targeting MICB variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The MICB Gene in Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/micb/"><em><span style="font-weight: 400;">MICB</span></em></a> <span style="font-weight: 400;">gene is closely related to the major histocompatibility complex (MHC) gene family, also known as the HLA system in humans. HLA proteins on the surface of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> flag harmful external components and stimulate the immune response against them [</span><a href="https://www.cell.com/trends/immunology/comments/S1471-4906(01)01960-3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with lupus and other autoimmune conditions, HLA proteins may have increased activity or impaired structure. These changes cause them to target the body&rsquo;s own components, such as skin &amp; joints, and trigger </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC474884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your MICB Results for Lupus</strong></h2> <p>*4461432397720979*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs558702/"><strong>rs558702</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely increases MICB activity</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs3135394/"><strong>rs3135394</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely increases MICB activity</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs1150755/"><strong>rs1150755</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely increases MICB activity</span></li> </ul> <p>*1698721824034834*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent or Improve Lupus</strong></h2> <p>*9934913148443099*</p> <h3><strong>Avoid Cigarette Smoke</strong></h3> <p><span style="font-weight: 400;">Smoking may worsen the impact of HLA-related genes on autoimmunity and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581918/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798887/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to several meta-analyses, the risk of lupus increases by approximately 50% in current but not in former smokers. Moreover, smoking may reduce the effectiveness of lupus drug treatment by 50%-90% [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520802/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26188616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25648824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarette smoke may worsen the impact of your MICB variants on lupus development.</span></p> <h3><strong>Fatty Fish/Omega-3</strong></h3> <p><span style="font-weight: 400;">Omega-3 fatty acids from </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> (EPA and DHA) may help with autoimmune conditions by reducing the activity of HLA (MHC) proteins on immune cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17499970/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18632990/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12480795/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lupus tend to have high levels of blood lipids (fats such as </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">), leading to increased risk of premature heart disease. Increased fish consumption may reverse these changes by improving blood lipid status and heart health [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7783060/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12375321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14705221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20048486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12912821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/omega-3/art-20045614"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fatty sea fish&mdash;such as salmon, sardine and herring&mdash;are the best omega-3 sources [</span><a href="https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/omega-3/art-20045614"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In many well-designed clinical trials, omega-3 supplementation reduced blood triglycerides by 15%-50%. DHA-containing products might increase LDL cholesterol, which is not an issue with EPA-only prescription omega-3s [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21975919"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9129504"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646219/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29280361"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671468/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increase your fish intake and consider taking omega-3 supplements to prevent the adverse metabolic effects of lupus.</span></p> <h3><strong>Vitamin D</strong></h3> <p><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> may have beneficial effects on autoimmunity by suppressing HLA proteins. Vitamin D significantly reduced MICB activity in test tubes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16046118"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21948571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lupus have lower vitamin D levels and are at a higher risk of deficiency, according to several meta-analyses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520805/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31468723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29412807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30636593/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one meta-analysis, vitamin D supplementation improved the status of this vitamin and reduced fatigue from lupus, but it didn&rsquo;t reduce lupus severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31331447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin D supplementation may correct a deficiency and reduce fatigue in lupus patients by targeting MICB variants.</span></p>
528 | content_snp_table_4461432397720979_key == 4461432397720979
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528 | content_learn_more_1698721824034834_text == Based on the variants we looked at, your MICB gene is associated with slightly higher odds of lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Avoid cigarette smoke, increase your fish intake, and consider taking certain supplements to lessen the impact of your variants on lupus. Keep reading to learn more.
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rsIDs = rs3135394,rs1150755,rs558702
rsStatus = rs3135394,HLA-DRA,chr6,32440720,A,G,,,2,0,Normal
rsStatus = rs1150755,TNXB,chr6,32070773,C,T,,,8,0,Normal
rsStatus = rs558702,C2,chr6,31902549,G,A,,,9,0,Normal
