529 | id == 529
529 | category_id == 29
529 | category_order == 26
529 | category_name == Lupus
529 | category_color == #C47AC0
529 | slug == TNFAIP3-lupus
529 | title == Inflammatory Protein Modulation & Lupus (TNFAIP3)
529 | meta_description == TNFAIP3 helps modulate protein activity. Variants of TNFAIP3 have been associated with lupus. Read more here.
529 | summary == <p style="text-align:justify"><strong>TNFAIP3 may help modulate protein breakdown, location, activity, and interactions&hellip; but how might <em>TNFAIP3</em> variants increase the risk of lupus? Read more to find out.</strong></p>
529 | overall_score_text == Your Lupus Score (based on TNFAIP3 gene)
529 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SD-Blog-Template.jpg
529 | author_id == 14
529 | author_name == Shany Lahan
529 | author_title == MS (Neuroscience)
529 | author_order == 5
529 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
529 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
529 | reviewer == None
529 | medical_reviewer_id == 11
529 | medical_reviewer_name == Puya Yazdi
529 | medical_reviewer_title == MD
529 | publish_date == 2020
529 | publish_date == 12
529 | publish_date == 4
529 | avg_rating == 5.0
529 | tags_id == 926
529 | tags_name == Autoantibodies
529 | tags_id == 33
529 | tags_name == Autoimmunity
529 | tags_id == 768
529 | tags_name == Cell Death
529 | tags_id == 369
529 | tags_name == NF-κB
529 | tags_id == 964
529 | tags_name == TNFAIP3 Gene
529 | tags_id == 841
529 | tags_name == Ubiquitin
529 | tags_id == 843
529 | tags_name == Ubiquitination
529 | permissions_favorite == False
529 | permissions_rate == False
529 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">TNFAIP3 </span></em><span style="font-weight: 400;">gene encodes A20, an enzyme involved in modulating the activity of the inflammatory protein NF-kB. Variants of </span><em><span style="font-weight: 400;">TNFAIP3 </span></em><span style="font-weight: 400;">may play a role in lupus by decreasing the production or activity of A20. Lifestyle and supplement modifications may counteract the effects of these variants by increasing A20 production and suppressing NF-kB.</span></span></p> <h2 style="text-align: justify;"><strong><em>TNFAIP3</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tnfaip3/"><em><span style="font-weight: 400;">TNFAIP3</span></em></a> <span style="font-weight: 400;">gene codes for tumor necrosis factor alpha-induced protein 3 (TNFAIP3), more commonly referred to as A20. This enzyme is involved in modulating the attachment of ubiquitin molecules to proteins, as well as protecting against cell death [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7128"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ubiquitin attachment and removal may alter protein breakdown, activity, location, and interactions. A20 may specifically be involved in suppressing the activity of protein </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7923371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32334614/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB has the potential to stimulate the release of inflammatory proteins, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">TNFAIP3 </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may decrease the production or activity of A20, which may lead to excess production of NF-kB, inflammatory protein release, autoantibody formation, and cell death [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26663301"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30573655"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21841782/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>TNFAIP3</em></strong><strong> Results for Lupus</strong></h2> <p style="text-align: justify;">*2064017046302273*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs5029939/"><strong>rs5029939</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with lupus&nbsp;</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs5029937/"><strong>rs5029937</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of lupus&nbsp;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with lupus&nbsp;</span></li> </ul> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs2230926/"><strong>rs2230926</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26663301"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with lupus&nbsp;</span></li> </ul> <p style="text-align: justify;"><strong><em>TNFAIP3 </em></strong><a href="https://selfdecode.com/snp/rs58721818/"><strong>rs58721818</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/30573655"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of lupus&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;">*2386269445387101*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*9242864900586314*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Acupuncture&nbsp;</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of rats, a form of</span> <a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> involving electric currents (electroacupuncture) was found to suppress NF-kB activation by increasing the production of A20 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27716383/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Acupuncture may help relieve muscle </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> associated with lupus. In a small trial of lupus patients, standard care failed to reduce pain, while a 10-session course of acupuncture reduced pain by at least 30% in the patients who received it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633212/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may help manage lupus by increasing the production of A20 and suppressing NF-kB.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Omega-3 Fatty Acids</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;"> fatty acids increased the production of A20 in cell- and animal-based studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25631736/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19056659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 6 clinical trials of patients with lupus, supplementation with 3-20 g omega-3 per day for up to 6 months improved symptoms, fatigue, quality of life, blood vessel function, blood fat profile, inflammatory markers, and oxidative stress [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2186476/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15290734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17875549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7562770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, the results are mixed: omega-3 fatty acids were ineffective at improving lupus severity and kidney damage in 4 trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8355469/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8172205/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29173690/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Omega-3 fatty acids may help manage lupus by increasing A20 production.</span></p> <h4 style="text-align: justify;"><strong>Zinc</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">A20 requires </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> for its activation, and studies have shown that zinc may even suppress NF-kB by increasing A20 production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with autoimmune diseases, including lupus, are more likely to have a zinc deficiency than the healthy population. In animals, zinc deprivation worsened the symptoms of autoimmune diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6982939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Zinc is available as a supplement, and the richest dietary sources of zinc include beef, pork, oysters and other seafood [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc may help manage lupus by increasing A20 production and suppressing NF-kB.</span></p>
529 | content_snp_table_2064017046302273_key == 2064017046302273
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529 | content_snp_table_2064017046302273_hidden == False
529 | content_learn_more_2386269445387101_key == 2386269445387101
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529 | content_learn_more_2386269445387101_text == Based on the variants we looked at, your TNFAIP3 gene makes you somewhat more likely to develop lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Acupuncture, omega-3 supplements, and zinc supplements may help. Keep scrolling to find out more.
529 | content_recommendation_9242864900586314_key == 9242864900586314
529 | content_recommendation_9242864900586314_blur == True
529 | content_recommendation_9242864900586314_hidden == False
rsIDs = rs2230926,rs5029939,rs5029937,rs58721818
rsStatus = rs2230926,TNFAIP3,chr6,137874929,T,C,G,,36,0,Normal
rsStatus = rs5029939,TNFAIP3,chr6,137874586,C,G,,,32,0,Normal
rsStatus = rs5029937,TNFAIP3,chr6,137874014,G,A,T,,27,0,Normal
rsStatus = rs58721818,,chr6,137922602,C,G,T,,38,0,Normal
