530 | id == 530
530 | category_id == 29
530 | category_order == 26
530 | category_name == Lupus
530 | category_color == #C47AC0
530 | slug == TNIP1-lupus
530 | title == Inflammatory Protein Suppression in Lupus (TNIP1)
530 | meta_description == TNIP1 helps modulate inflammatory protein activity. Variants of TNIP1 have been associated with lupus. Read more here.
530 | summary == <p style="text-align:justify"><strong>TNIP1 may help suppress an inflammatory protein&hellip; but how might <em>TNIP1</em> variants increase the risk of lupus? Read more to find out.</strong></p>
530 | overall_score_text == Your Lupus Score (based on TNIP1 gene)
530 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TNIP1-Lupus.jpg
530 | author_id == 14
530 | author_name == Shany Lahan
530 | author_title == MS (Neuroscience)
530 | author_order == 5
530 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
530 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
530 | reviewer == None
530 | medical_reviewer_id == 11
530 | medical_reviewer_name == Puya Yazdi
530 | medical_reviewer_title == MD
530 | publish_date == 2020
530 | publish_date == 12
530 | publish_date == 4
530 | avg_rating == 5.0
530 | tags_id == 926
530 | tags_name == Autoantibodies
530 | tags_id == 33
530 | tags_name == Autoimmunity
530 | tags_id == 24
530 | tags_name == Inflammation
530 | tags_id == 369
530 | tags_name == NF-κB
530 | tags_id == 964
530 | tags_name == TNFAIP3 Gene
530 | tags_id == 1011
530 | tags_name == TNIP1 Gene
530 | permissions_favorite == False
530 | permissions_rate == False
530 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">TNIP1 helps modulate the activity of the inflammatory protein NF-kB by interacting with TNFAIP3. Variants of </span><em><span style="font-weight: 400;">TNIP1 </span></em><span style="font-weight: 400;">may play a role in lupus by decreasing the production of TNIP1. Lifestyle and supplement modifications may counteract the effects of these variants by increasing TNFAIP3 production and suppressing NF-kB.</span></span></p> <h2 style="text-align: justify;"><strong><em>TNIP1</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tnip1/"><em><span style="font-weight: 400;">TNIP1</span></em></a> <span style="font-weight: 400;">gene codes for TNFAIP3-interacting protein 1 (TNIP1). TNIP1 is a protein that may suppress the activity of </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;">, either alone or (as its name suggests) by interacting with </span><a href="https://selfdecode.com/blog/article/TNFAIP3-lupus-529/"><span style="font-weight: 400;">TNFAIP3</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10318"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192141/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32334614/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">NF-kB is a protein with the potential to stimulate inflammatory protein release, as well as promote the formation of antibodies that recognize the body&rsquo;s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18613848/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">TNIP1 </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may decrease the production of TNIP1, which may result in reduced activity of TNFAIP3, activation of NF-kB, inflammatory protein release, and autoantibody formation [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27659348/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207663/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21841782/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>TNIP1 </em></strong><strong>Results for Lupus</strong></h2> <p style="text-align: justify;">*7085154067029766*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>TNIP1 </em></strong><a href="https://selfdecode.com/snp/rs10036748/"><strong>rs10036748</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of lupus&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with lupus&nbsp;</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>TNIP1 </em></strong><a href="https://selfdecode.com/snp/rs6889239/"><strong>rs6889239</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;"><strong><em>TNIP1 </em></strong><a href="https://selfdecode.com/snp/rs7708392/"><strong>rs7708392</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus</span><span style="font-weight: 400;">&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with lupus</span></li> </ul> <p style="text-align: justify;">*5733630080949748*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*6402303112885865*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Acupuncture&nbsp;</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of rats, a form of</span> <a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> involving electric currents (electroacupuncture) was found to suppress NF-kB activation by increasing the production of TNFAIP3 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27716383/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Acupuncture may help relieve muscle </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> associated with lupus. In a small trial of lupus patients, standard care failed to reduce pain, while a 10-session course of acupuncture reduced pain by at least 30% in the patients who received it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633212/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may help manage lupus by increasing the production of <span style="font-weight: 400;">TNFAIP3</span> and suppressing NF-kB.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Omega-3 Fatty Acids</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;"> fatty acids increased the production of TNFAIP3 in cell- and animal-based studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25631736/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19056659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In 6 clinical trials of patients with lupus, supplementation with 3-20 g omega-3 per day for up to 6 months improved symptoms, fatigue, quality of life, blood vessel function, blood fat profile, inflammatory markers, and oxidative stress [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2186476/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15290734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17875549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7562770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, the results are mixed: omega-3 fatty acids were ineffective at improving lupus severity and kidney damage in 4 trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8355469/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8172205/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29173690/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805738/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Omega-3 fatty acids may help manage lupus by increasing <span style="font-weight: 400;">TNFAIP3</span> production.</span></p> <h4 style="text-align: justify;"><strong>Zinc</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">TNFAIP3 requires </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> for its activation, and studies have shown that zinc may even suppress NF-kB by increasing TNFAIP3 production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with autoimmune diseases, including lupus, are more likely to have a zinc deficiency than the healthy population. In animals, zinc deprivation worsened the symptoms of autoimmune diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6982939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Zinc is available as a supplement, and the richest dietary sources of zinc include beef, pork, oysters and other seafood [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc may help manage lupus by increasing <span style="font-weight: 400;">TNFAIP3</span> production and suppressing NF-kB.</span></p>
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530 | content_learn_more_5733630080949748_text == Based on the variants we looked at, your TNIP1 gene makes you somewhat more likely to develop lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Acupuncture, omega-3 fatty acid supplements, and zinc supplements may help. Keep scrolling to find out more.
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rsIDs = rs7708392,rs10036748,rs6889239
rsStatus = rs7708392,TNIP1,chr5,151077924,G,C,,,22,8,HET
rsStatus = rs10036748,TNIP1,chr5,151078585,C,A,T,,36,0,Normal
rsStatus = rs6889239,TNIP1,chr5,151078210,T,C,,,30,18,HET
