532 | id == 532
532 | category_id == 29
532 | category_order == 26
532 | category_name == Lupus
532 | category_color == #C47AC0
532 | slug == UHRF1BP1-lupus
532 | title == Surprising Genetic Factor for Lupus (UHRF1BP1)
532 | meta_description == The UHRF1BP1 gene controls the inflammatory response in lupus development. Click to check your variants.
532 | summary == <p style="text-align:justify"><strong>The <em>UHRF1BP1</em> gene plays a major role in lupus-related inflammation. Don&rsquo;t try to spell its name, but make sure to check your variants and get our personalized tips!</strong></p>
532 | overall_score_text == Your Lupus Score (based on UHRF1BP1 gene)
532 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/UHRF1BP1-Lupus.jpg
532 | author_id == 9
532 | author_name == Aleksa Ristic
532 | author_title == MS (Pharmacy)
532 | author_order == 45
532 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
532 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
532 | reviewer == None
532 | medical_reviewer_id == 11
532 | medical_reviewer_name == Puya Yazdi
532 | medical_reviewer_title == MD
532 | publish_date == 2020
532 | publish_date == 12
532 | publish_date == 5
532 | avg_rating == 5.0
532 | tags_id == 24
532 | tags_name == Inflammation
532 | tags_id == 84
532 | tags_name == Lupus
532 | tags_id == 1012
532 | tags_name == MIF
532 | tags_id == 1013
532 | tags_name == UHRF1BP1 gene
532 | permissions_favorite == False
532 | permissions_rate == False
532 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The </strong><strong><em>UHRF1BP1</em></strong><strong> gene controls the release of MIF, an inflammatory protein involved in lupus development.<br /><br /></strong><strong>Specific gene variants may alter </strong><strong><em>UHRF1BP1 </em></strong><strong>activity and increase MIF levels. They correlate with higher lupus rates.<br /><br /></strong><strong>Dietary and lifestyle changes may prevent or improve lupus by targeting </strong><strong><em>UHRF1BP1 </em></strong><strong>variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Link Between UHRF1BP1 and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/uhrf1bp1/"><em><span style="font-weight: 400;">UHRF1BP1</span></em></a><span style="font-weight: 400;"> gene controls the release of </span><em><span style="font-weight: 400;">macrophage migration inhibitory factor</span></em><span style="font-weight: 400;"> (MIF) from </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/PMC/2925843"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31691269/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">MIF is an inflammatory protein involved in autoimmune conditions such as rheumatoid arthritis and lupus. Scientists have been developing lupus medications that inhibit MIF [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800059/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14760795/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800059/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your UHRF1BP1 Results for Lupus</strong></h2> <p>*3324425844205902*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs3734266/"><strong>rs3734266</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely alters UHRF1BP1 activity and increases MIF levels.</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs9462027/"><strong>rs9462027</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ncomms16021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely alters UHRF1BP1 activity and increases MIF levels.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs11755393/"><strong>rs11755393</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely alters UHRF1BP1 activity and increases MIF levels.</span></li> </ul> <p>*6149096917965104*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent &amp; Improve Lupus</strong></h2> <p>*6583942759027539*</p> <h3><strong>Stress Reduction</strong></h3> <p><span style="font-weight: 400;">Macrophage migration inhibitory factor (MIF) can trigger </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;"> in response to psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29870971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22575600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27129368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study, daily stress worsened performance in visual memory, visual fluency, and attention in lupus patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17211991/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Stress-management interventions such as cognitive-behavioral therapy or counseling may reduce </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and lupus severity while improving life quality. However, a meta-analysis concluded that the evidence is based on low-quality studies and requires further investigation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199565/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15334437/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20841339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22570339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid psychological stress and consult with your doctor about relaxation therapies to lessen the impact of your gene variants on lupus.</span></p> <h3><strong>Green Tea</strong></h3> <p><span style="font-weight: 400;">Catechins, active ingredients in </span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;">, may reduce inflammation by inhibiting MIF [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22050122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24916123"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one clinical trial, taking 1000 mg/day of a green tea extract (equivalent to one cup of tea) for 12 weeks improved lupus severity and quality of life [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28585735/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h3><strong>N-acetylcysteine (NAC)</strong></h3> <p><span style="font-weight: 400;">In the presence of </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;">, white blood cells release higher amounts of MIF. </span><a href="http://selfhacked.com/blog/top-25-science-based-health-benefits-n-acetyl-cysteine-nac/"><span style="font-weight: 400;">N-acetylcysteine</span></a><span style="font-weight: 400;"> (NAC) may inhibit this process thanks to its antioxidant properties [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922441/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22629429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824032/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">NAC supplementation (2.4-4.8 g/day) reduced lupus severity, fatigue, and the overactive immune response in one study. The same doses reduced ADHD symptoms in 49 patients with lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Green tea and N-acetylcysteine (NAC) may improve lupus by targeting your gene variants.</span></p>
532 | content_snp_table_3324425844205902_key == 3324425844205902
532 | content_snp_table_3324425844205902_blur == True
532 | content_snp_table_3324425844205902_hidden == False
532 | content_learn_more_6149096917965104_key == 6149096917965104
532 | content_learn_more_6149096917965104_blur == True
532 | content_learn_more_6149096917965104_hidden == False
532 | content_learn_more_6149096917965104_text == Based on the variants we looked at, your UHRF1BP1 gene is associated with slightly higher odds of lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Try to reduce stress and drink green tea to lessen the impact of your variants on lupus. Keep reading to learn more.
532 | content_recommendation_6583942759027539_key == 6583942759027539
532 | content_recommendation_6583942759027539_blur == True
532 | content_recommendation_6583942759027539_hidden == False
rsIDs = rs11755393,rs3734266,rs9462027
rsStatus = rs11755393,UHRF1BP1,chr6,34856859,A,G,T,,30,0,Normal
rsStatus = rs3734266,UHRF1BP1,chr6,34855410,T,C,,,37,0,Normal
rsStatus = rs9462027,UHRF1BP1,chr6,34829464,G,A,,,27,0,Normal
