533 | id == 533
533 | category_id == 29
533 | category_order == 26
533 | category_name == Lupus
533 | category_color == #C47AC0
533 | slug == RASGRP3-lupus
533 | title == B Cell Activity & Lupus Progression (RASGRP3)
533 | meta_description == RASGRP3 mediates B cell activity and survival. A variant of RASGRP3 has been linked to lupus. Read more here.
533 | summary == <p style="text-align:justify"><strong>RASGRP3 helps mediate B cell activity and survival. How might variants of <em>RASGRP3</em> lead to B cell overactivity and promote lupus progression? Read more to find out.</strong></p>
533 | overall_score_text == Your Lupus Score (based on RASGRP3 gene)
533 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RASGRP3-Lupus.jpg
533 | author_id == 14
533 | author_name == Shany Lahan
533 | author_title == MS (Neuroscience)
533 | author_order == 5
533 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
533 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
533 | reviewer == None
533 | medical_reviewer_id == 11
533 | medical_reviewer_name == Puya Yazdi
533 | medical_reviewer_title == MD
533 | publish_date == 2020
533 | publish_date == 12
533 | publish_date == 7
533 | avg_rating == 5.0
533 | tags_id == 926
533 | tags_name == Autoantibodies
533 | tags_id == 33
533 | tags_name == Autoimmunity
533 | tags_id == 242
533 | tags_name == B cells
533 | tags_id == 253
533 | tags_name == IL-6
533 | tags_id == 24
533 | tags_name == Inflammation
533 | tags_id == 1014
533 | tags_name == RASGRP3 Gene
533 | tags_id == 235
533 | tags_name == TNF-alpha
533 | permissions_favorite == False
533 | permissions_rate == False
533 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">RASGRP3 promotes the activity and survival of B cells. A variant of </span><em><span style="font-weight: 400;">RASGRP3 </span></em><span style="font-weight: 400;">may play a role in lupus by increasing the production of RASGRP3, leading to B cell overactivity, inflammation, and autoimmunity. Lifestyle, diet, and supplement modifications may counteract the effects of this variant by decreasing the production of RASGRP3 or an inflammatory protein.</span></span></p> <h2 style="text-align: justify;"><strong><em>RASGRP3</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">RASGRP3 </span></em><span style="font-weight: 400;">gene codes for RAS guanyl-releasing protein 3 (RASGRP3), a protein involved in mediating signals that promote the activity and survival of B cells [</span><a href="https://www.ncbi.nlm.nih.gov/gene/25780"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">B cells have the ability to generate antibodies and release immune messengers known as cytokines. Such interactions are essential for ridding the body of foreign invaders, such as bacteria [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523822/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In the autoimmune disorder lupus, B cell activity is dysregulated, leading to excessive growth and expansion (proliferation) of B cells, inflammation, and the production of autoantibodies -- antibodies that mistakenly target parts of the body [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456560/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523822/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Elevated RASGRP3 has been observed in B cells derived from lupus patients. This increase may promote the B cell-mediated release of the pro-inflammatory cytokines </span><a href="https://selfhack.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhack.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;">. While IL-6 may stimulate B cells to produce autoantibodies, TNF-alpha has been implicated in kidney damage [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456560/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17587156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15661926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8948291/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9034987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">An increase in RASGRP3 may also prevent the death of overactive B cells, thereby contributing to the production of pro-inflammatory cytokines and autoantibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456560/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">RASGRP3 </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may increase the production of RASGRP3, resulting in dysregulated B cell activity, pro-inflammatory cytokine release, and autoantibody generation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456560/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>RASGRP3 </em></strong><strong>Results for Lupus</strong></h2> <p style="text-align: justify;">*3104255805831373*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>RASGRP3 </em></strong><a href="https://selfdecode.com/snp/rs13385731/"><strong>rs13385731</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of lupus, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower odds of lupus, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;">*9252112780829724*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*9769244170041635*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Cigarettes</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In human lung cells, exposure to cigarette smoke increased the production of RASGRP3 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30291989/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Several meta-analyses found that the risk of lupus increases by approximately 50% in current but not in former smokers. Moreover, smoking may reduce the effectiveness of antimalarials such as hydroxychloroquine (used for skin injuries) by 50% and immunosuppressants such as belimumab (used for systemic symptoms) by 90% [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520802/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26188616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25648824/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarette smoke may increase the production of RASGRP3. Avoiding cigarette smoke may help manage lupus by preventing an increase in this protein.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, fruits, vegetables, and fish, but low in red meat, sugars, and pastries.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Pentanal, a compound found in olive oil, decreased the production of RASGRP3 in human cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26079696/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Practicing the Mediterranean diet reduced lupus severity and the risk of heart disease in a study of people suffering from this condition [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32594173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, a large study of women found that high-quality diets (including the Mediterranean diet) didn&rsquo;t reduce the risk of developing lupus. The study only suggested a reduced risk of lupus in those with a high intake of nuts and legumes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32936999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage lupus by decreasing production of RASGRP3.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Curcumin (Turmeric)</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the primary active compound of the yellow spice turmeric.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies have demonstrated that curcumin may lower the production and activity of IL-6 and TNF-alpha, suggesting that it may be beneficial for individuals carrying risk variants of </span><em><span style="font-weight: 400;">RASGRP3 </span></em><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/27719643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753829/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to a preliminary trial of lupus patients, short-term turmeric supplementation may decrease blood and kidney damage (measured as protein in the urine) along with systolic blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21742514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin may help manage lupus by decreasing production of the pro-inflammatory proteins IL-6 and TNF-alpha.</span></p>
533 | content_snp_table_3104255805831373_key == 3104255805831373
533 | content_snp_table_3104255805831373_blur == True
533 | content_snp_table_3104255805831373_hidden == False
533 | content_learn_more_9252112780829724_key == 9252112780829724
533 | content_learn_more_9252112780829724_blur == True
533 | content_learn_more_9252112780829724_hidden == False
533 | content_learn_more_9252112780829724_text == Based on the variants we looked at, your RASGRP3 gene is associated with somewhat higher odds of lupus, relative to other variants. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Avoiding cigarettes, adhering to the Mediterranean diet, and taking curcumin supplements may help. Keep scrolling to find out more.
533 | content_recommendation_9769244170041635_key == 9769244170041635
533 | content_recommendation_9769244170041635_blur == True
533 | content_recommendation_9769244170041635_hidden == False
rsIDs = rs13385731
rsStatus = rs13385731,RASGRP3,chr2,33476823,T,C,,,22,0,Normal
