534 | id == 534
534 | category_id == 29
534 | category_order == 26
534 | category_name == Lupus
534 | category_color == #C47AC0
534 | slug == STAT4-th1-th17-lupus
534 | title == Disrupted Immune Balance in Lupus (STAT4)
534 | meta_description == The STAT4 gene stimulates the immune cells involved in autoimmunity. Learn about its link with lupus.
534 | summary == <p style="text-align:justify"><strong>Excess STAT4 activity may shift your immune response towards autoimmunity. Read on to learn about the link between this gene and lupus&mdash;personalized tips included!</strong></p>
534 | overall_score_text == Your Lupus Score (based on STAT4 gene)
534 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/STAT4-Lupus.jpg
534 | author_id == 9
534 | author_name == Aleksa Ristic
534 | author_title == MS (Pharmacy)
534 | author_order == 45
534 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
534 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
534 | reviewer == None
534 | medical_reviewer_id == 11
534 | medical_reviewer_name == Puya Yazdi
534 | medical_reviewer_title == MD
534 | publish_date == 2020
534 | publish_date == 12
534 | publish_date == 7
534 | avg_rating == 5.0
534 | tags_id == 33
534 | tags_name == Autoimmunity
534 | tags_id == 84
534 | tags_name == Lupus
534 | tags_id == 1015
534 | tags_name == STAT4 gene
534 | tags_id == 440
534 | tags_name == Th17 Cells
534 | tags_id == 435
534 | tags_name == Th1 Cells
534 | permissions_favorite == False
534 | permissions_rate == False
534 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The STAT4 gene increases the activity of immune cells involved in autoimmunity.<br /><br /></strong><strong>Specific gene variants may influence lupus susceptibility by changing STAT4 activity.<br /><br /></strong><strong>This post reveals potential ways to improve lupus by targeting STAT4 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>STAT4 &amp; T Helper Cells in Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://www.selfdecode.com/gene/stat4/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><em><span style="font-weight: 400;">STAT4</span></em></a><span style="font-weight: 400;"> gene increases the activity of IL-12, IL-23, </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN-gamma</span></a><span style="font-weight: 400;">, and other inflammatory proteins. These proteins stimulate the development of immature T helper cells into </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17</span></a><span style="font-weight: 400;"> cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Th1 and Th17 cells play a role in different inflammatory and autoimmune conditions, making STAT4 a promising candidate for the genetic background of lupus development [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15546391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your STAT4 Results for Lupus</strong></h2> <p>*4014506774484305*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs7574865/"><strong>rs7574865</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely reduces STAT4 activity.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs11889341/"><strong>rs11889341</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely increases STAT4 activity.</span></li> </ul> <p><strong>Other Important SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs7601754/"><strong>rs7601754</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely increases STAT4 activity.</span></li> </ul> <p>*6934284397700696*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Lupus</strong></h2> <p>*1215457553503089*</p> <h3><strong>Exercise</strong></h3> <p><span style="font-weight: 400;">In one clinical study, aerobic </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> reduced STAT4 activity in lupus patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26859426/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">A meta-analysis involving 469 people with lupus concluded that aerobic exercise may improve fatigue, </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">, and physical fitness without worsening disease activity. People with mild lupus should practice moderate-intensity exercise for at least 20 minutes, 3 days/week [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28477898/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28432856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aerobic exercise may lessen the impact of your STAT4 variants on lupus development.</span></p> <h3><strong>Vitamin D</strong></h3> <p><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> treatment reduced STAT4 activity and autoimmune </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;"> in animal studies and test tubes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16547967/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289695/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lupus have lower vitamin D levels and are at a higher risk of deficiency, according to several meta-analyses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520805/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31468723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29412807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30636593/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one meta-analysis, vitamin D supplementation improved the status of this vitamin and reduced fatigue from lupus, but it didn&rsquo;t reduce lupus severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31331447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin D supplementation may improve the status of this vitamin and reduce fatigue from lupus.</span></p>
534 | content_snp_table_4014506774484305_key == 4014506774484305
534 | content_snp_table_4014506774484305_blur == True
534 | content_snp_table_4014506774484305_hidden == False
534 | content_learn_more_6934284397700696_key == 6934284397700696
534 | content_learn_more_6934284397700696_blur == True
534 | content_learn_more_6934284397700696_hidden == False
534 | content_learn_more_6934284397700696_text == Based on the variants we looked at, your STAT4 gene is associated with relatively higher odds of lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Exercise regularly and consider supplementing with vitamin D to lessen the impact of your variants on lupus. Keep reading to learn more.
534 | content_recommendation_1215457553503089_key == 1215457553503089
534 | content_recommendation_1215457553503089_blur == True
534 | content_recommendation_1215457553503089_hidden == False
rsIDs = rs7601754,rs11889341,rs7574865
rsStatus = rs7601754,STAT4,chr2,191075725,G,A,C,T,14,10,HET
rsStatus = rs11889341,STAT4,chr2,191079016,C,T,,,18,0,Normal
rsStatus = rs7574865,STAT4,chr2,191099907,T,A,G,,23,0,Normal
