536 | id == 536
536 | category_id == 29
536 | category_order == 26
536 | category_name == Lupus
536 | category_color == #C47AC0
536 | slug == ARID5B-lupus
536 | title == The Role of a Cell Cycle Regulator Gene in Lupus (ARID5B)
536 | meta_description == The ARID5B gene helps regulate the growth of white blood cells & the production of p21. What is its connection to lupus?
536 | summary == <p><strong>The <em>ARID5B </em>gene helps regulate the growth of white blood cells &amp; the production of p21. What is its connection to lupus? Read on to find out.</strong></p>
536 | overall_score_text == Your Lupus Score (based on ARID5B)
536 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ARID5B-Lupus.jpg
536 | author_id == 1
536 | author_name == Jasmine Foster
536 | author_title == BSc, BEd
536 | author_order == 36
536 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
536 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
536 | reviewer == None
536 | medical_reviewer_id == 11
536 | medical_reviewer_name == Puya Yazdi
536 | medical_reviewer_title == MD
536 | publish_date == 2020
536 | publish_date == 12
536 | publish_date == 7
536 | avg_rating == 5.0
536 | tags_id == 948
536 | tags_name == ARID5B
536 | tags_id == 33
536 | tags_name == Autoimmunity
536 | tags_id == 768
536 | tags_name == Cell Death
536 | tags_id == 95
536 | tags_name == Immune System
536 | tags_id == 24
536 | tags_name == Inflammation
536 | tags_id == 84
536 | tags_name == Lupus
536 | tags_id == 949
536 | tags_name == p21
536 | tags_id == 947
536 | tags_name == White Blood Cells
536 | permissions_favorite == False
536 | permissions_rate == False
536 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ARID5B</span></em><span style="font-weight: 400;"> encodes AT-rich interaction domain 5B. Variants of </span><em><span style="font-weight: 400;">ARID5B</span></em><span style="font-weight: 400;"> may play a role in lupus by increasing the activity of white blood cells and reducing levels of protective p21. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing p21.</span></p> <h2><strong><em>ARID5B</em></strong><strong> and Lupus</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/arid5b/"><em><span style="font-weight: 400;">ARID5B</span></em></a> <span style="font-weight: 400;">gene encodes a protein called AT-rich interaction domain 5B, which helps regulate the growth and development of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=84159"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Reduced ARID5B activity may lower the rate of white blood cell maturation and play a role in different types of leukemia. On the other hand, excess ARID5B activity may overstimulate white blood cells and contribute to autoimmune conditions. Thus, it&rsquo;s important for ARID5B activity to be well-balanced [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11959810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">ARID5B inhibits p21, a protein that controls the division of inflammatory cells. Patients with autoimmune diseases tend to have lower than normal p21, leading to increased inflammation and tissue damage [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25077978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One variant in the </span><em><span style="font-weight: 400;">ARID5B </span></em><span style="font-weight: 400;">gene has been associated with lupus in European and Chinese populations [</span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25808444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ARID5B</span></em><span style="font-weight: 400;"> gene helps regulate the growth of white blood cells and the production of a protective protein called p21. Variants that increase ARID5B may promote autoimmune disease.</span></span></p> <h2><strong>Your </strong><strong><em>ARID5B</em></strong><strong> Results for Lupus</strong></h2> <p>*7735431805600574*</p> <p><a href="https://selfdecode.com/gene/arid5b/"><strong>ARID5B</strong></a> <a href="https://selfdecode.com/snp/rs4948496/"><strong>rs4948496</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively higher rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively lower rates of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may increase the production of p21 and reduce the rate of cell division, possibly protecting against autoimmune disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25077978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*1878184259493593*</p> <h2><strong>Recommendations for Autoimmune Inflammation</strong></h2> <p>*4008964361593037*</p> <h3><strong>Exercise</strong></h3> <p><span style="font-weight: 400;">The anti-inflammatory and anti-cancer potential of </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> partly lies in its ability to boost p21 and prevent excess cell division [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17923812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20216467/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 11 studies involving 469 people with lupus concluded that 12-week aerobic </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> programs may help improve fatigue, </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">, and physical fitness without worsening disease activity. People with mild lupus should begin with moderate intensity exercise for at least 20 minutes 3 days/week [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28477898/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28432856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Physical exercise appears to boost p21, prevent excess cell division, and improve lupus symptoms.</span></p> <h3><strong>Flaxseed</strong></h3> <p><span style="font-weight: 400;">Some compounds naturally found in </span><a href="https://selfhacked.com/blog/flaxseed-oil-benefits/"><span style="font-weight: 400;">flaxseed</span></a><span style="font-weight: 400;"> may increase the activity of p21 and prevent excessive immune cell activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23907590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 small trials (one of them non-placebo-controlled) of 49 people with lupus and kidney damage, taking 30 g of ground flaxseed daily improved kidney function while reducing inflammatory and artery-clogging markers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7564115/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11349937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Ground flaxseed contains compounds that may increase p21 activity and improve health markers in lupus patients.</span></p> <h3><strong>Green Tea</strong></h3> <p><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;">, the primary active compound in green tea, increases p21 in cell studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10806303/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a placebo-controlled trial of 68 people with lupus, taking 1000 mg/day of a </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;"> extract with 22% polyphenols (equivalent to one cup of green tea) for 12 weeks improved disease severity and quality of life [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28585735/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">EGCG from green tea increases p21 in cells and improves disease severity markers in lupus patients.</span></p> <h3><strong>Thunder God Vine</strong></h3> <p><span style="font-weight: 400;">The active components of </span><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">thunder god vine</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Tripterygium wilfordii</span></em><span style="font-weight: 400;">) may prevent uncontrolled cell division by boosting p21 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25400429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741730/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/"><span style="font-weight: 400;">Thunder god vine</span></a><span style="font-weight: 400;"> improved several cases of lupus in China. Most of the studies (a combination of case studies and non-placebo controlled trials) that support its use date back to the 80s, leaving this benefit uncertain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2791160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10680192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6800725/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6555446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18652362/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25058036/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29193402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In mice with lupus, thunder god vine increased survival and reduced kidney damage and inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/1445458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1728981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526566/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560846/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15840409/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Thunder god vine may increase p21, prevent uncontrolled cell division, and improve markers of kidney damage and inflammation in lupus patients.</span></p>
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536 | content_learn_more_1878184259493593_text == Based on the variants we looked at, your ARID5B gene is somewhat associated with autoimmune inflammation. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Exercise, flaxseed, green tea, and thunder god vine may help. Keep scrolling to find out more.
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rsIDs = rs4948496
rsStatus = rs4948496,ARID5B,chr10,62045858,T,A,C,,29,0,Normal
