537 | id == 537
537 | category_id == 29
537 | category_order == 26
537 | category_name == Lupus
537 | category_color == #C47AC0
537 | slug == PRDM1-lupus
537 | title == B Cell Activity in Lupus (PRDM1)
537 | meta_description == PRDM1 promotes antibody release. Variants of PRDM1 are linked to lupus. Read more here.
537 | summary == <p style="text-align:justify"><strong>The <em>PRDM1</em> gene codes for a protein that promotes the development and activity of antibody-releasing immune cells. How might variants of <em>PRDM1</em> alter immune responses and promote the development of lupus? Read more to find out.</strong></p>
537 | overall_score_text == Your Lupus Score (based on PRDM1 gene)
537 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PRDM1-Lupus.jpg
537 | author_id == 14
537 | author_name == Shany Lahan
537 | author_title == MS (Neuroscience)
537 | author_order == 5
537 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
537 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
537 | reviewer == None
537 | medical_reviewer_id == 11
537 | medical_reviewer_name == Puya Yazdi
537 | medical_reviewer_title == MD
537 | publish_date == 2020
537 | publish_date == 12
537 | publish_date == 8
537 | avg_rating == 5.0
537 | tags_id == 926
537 | tags_name == Autoantibodies
537 | tags_id == 33
537 | tags_name == Autoimmunity
537 | tags_id == 242
537 | tags_name == B cells
537 | tags_id == 648
537 | tags_name == Dendritic Cells
537 | tags_id == 24
537 | tags_name == Inflammation
537 | tags_id == 1017
537 | tags_name == PRDM1 Gene
537 | permissions_favorite == False
537 | permissions_rate == False
537 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PRDM1 </span></em><span style="font-weight: 400;">gene codes for B lymphocyte-induced maturation protein 1 (BLIMP-1), a protein that promotes immune cell activity by suppressing Fc gamma receptor IIb. Variants of </span><em><span style="font-weight: 400;">PRDM1 </span></em><span style="font-weight: 400;">may play a role in lupus by dysregulating the production of BLIMP-1. Diet and supplement modifications may counteract the effects of these variants by promoting Fc gamma receptor IIb activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>PRDM1</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/prdm1/"><em><span style="font-weight: 400;">PRDM1</span></em></a> <span style="font-weight: 400;">gene codes for B lymphocyte-induced maturation protein 1 (BLIMP-1), a protein that promotes the maturation of B cells and the B cell-mediated release of antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/gene/639"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In autoimmune disorders such as lupus, B cells play critical roles in the production of antibodies that target the body&rsquo;s own tissues (autoantibodies). In line with this, studies have shown that BLIMP-1 levels are increased in patients and animals with lupus [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23911415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">BLIMP-1 may also be involved in regulating the inflammatory response of a type of immune cell known as a dendritic cell. In dendritic cells of lupus patients, BLIMP-1 levels were lower in comparison to healthy controls. Interestingly, this same study did not find any differences in BLIMP-1 production when comparing the B cells of lupus patients to those of controls [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23298838/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ultimately, the production of BLIMP-1 in lupus may vary depending on the cell type in question, and it&rsquo;s probable that BLIMP-1 levels must remain balanced in order to regulate the function of a variety of immune cells.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">BLIMP-1 has been suggested to decrease the production of </span><a href="https://selfdecode.com/blog/article/FCGR2B-lupus-517/"><span style="font-weight: 400;">Fc gamma receptor IIb</span></a><span style="font-weight: 400;">, a receptor that normally helps regulate immune responses by suppressing the activity of various immune cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">PRDM1 </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may dysregulate the production of BLIMP-1, resulting in decreased Fc gamma receptor IIb production, autoantibody release, and inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>PRDM1</em></strong><strong> Results for Lupus</strong></h2> <p style="text-align: justify;">*1755227304546762*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>PRDM1 </em></strong><a href="https://selfdecode.com/snp/rs548234/"><strong>rs548234</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19838193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Lower odds of lupus, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNP:</strong></p> <p style="text-align: justify;"><strong><em>PRDM1 </em></strong><a href="https://selfdecode.com/snp/rs6568431/"><strong>rs6568431</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of lupus, relative to</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower odds of lupus, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;">*5031009133064641*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*9559753537542943*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Lipid-Lowering Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In mice fed a </span><a href="https://selfhack.com/blog/saturatedfats-low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">diet high in saturated fat</span></a><span style="font-weight: 400;">, Fc gamma receptor IIb production decreased significantly -- in as little as 3 days. This suggests that avoiding saturated fat may prevent a decrease in the production of Fc gamma receptor IIb [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18042831/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with lupus tend to have high levels of blood lipids (fats such as </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">), leading to increased risk of premature heart disease. In 4 controlled trials of people with lupus, dietary interventions modestly improved blood lipid levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7783060/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12375321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14705221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29320971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Eating a lipid-lowering diet (for example, by limiting the intake of saturated fats) may help manage lupus by preventing a decrease in the production of Fc gamma receptor IIb.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Zinc</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The activity of Fc gamma receptor IIb may be dependent on </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22553781/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with autoimmune disorders, including lupus, are more likely to have a zinc deficiency than the healthy population. In animals, zinc deprivation worsened symptoms of autoimmune disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793296/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/6982939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Zinc is available as a supplement and is found in some foods. The richest dietary sources of zinc include beef, pork, oysters, and other seafood [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc may help manage lupus by promoting the activity of Fc gamma receptor IIb.</span></p>
537 | content_snp_table_1755227304546762_key == 1755227304546762
537 | content_snp_table_1755227304546762_blur == True
537 | content_snp_table_1755227304546762_hidden == False
537 | content_learn_more_5031009133064641_key == 5031009133064641
537 | content_learn_more_5031009133064641_blur == True
537 | content_learn_more_5031009133064641_hidden == False
537 | content_learn_more_5031009133064641_text == Based on the variants we looked at, your PRDM1 gene is associated with somewhat increased odds of lupus, relative to other variants. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Adhering to a lipid-lowering diet and taking zinc supplements may help. Keep scrolling to find out more.
537 | content_recommendation_9559753537542943_key == 9559753537542943
537 | content_recommendation_9559753537542943_blur == True
537 | content_recommendation_9559753537542943_hidden == False
rsIDs = rs548234,rs6568431
rsStatus = rs548234,,chr6,106120159,C,A,G,T,27,0,Normal
rsStatus = rs6568431,,chr6,106140931,A,C,,,21,16,HET
