538 | id == 538
538 | category_id == 29
538 | category_order == 26
538 | category_name == Lupus
538 | category_color == #C47AC0
538 | slug == PHRF1-interferons-lupus
538 | title == The Role of Interferons in Lupus (PHRF1)
538 | meta_description == The PHRF1 gene controls lupus-related inflammation. Click to learn the details and check your variant.
538 | summary == <p style="text-align:justify"><strong>Altered activity of <em>PHRF1</em> and other genes produce a unique &lsquo;interferon signature&rsquo; in lupus patients. Read this post to learn the details, check your variant, and get gene-based tips!</strong></p>
538 | overall_score_text == Your Lupus Score (based on PHRF1 gene)
538 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PHRF1-Lupus.jpg
538 | author_id == 9
538 | author_name == Aleksa Ristic
538 | author_title == MS (Pharmacy)
538 | author_order == 45
538 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
538 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
538 | reviewer == None
538 | medical_reviewer_id == 11
538 | medical_reviewer_name == Puya Yazdi
538 | medical_reviewer_title == MD
538 | publish_date == 2020
538 | publish_date == 12
538 | publish_date == 8
538 | avg_rating == 5.0
538 | tags_id == 33
538 | tags_name == Autoimmunity
538 | tags_id == 344
538 | tags_name == IFNα
538 | tags_id == 343
538 | tags_name == Interferons
538 | tags_id == 84
538 | tags_name == Lupus
538 | tags_id == 1018
538 | tags_name == PHRF1 gene
538 | permissions_favorite == False
538 | permissions_rate == False
538 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong><em>PHRF1</em></strong><strong> can influence the production of interferon-alpha (IFN-alpha), a crucial inflammatory protein in lupus development.<br /><br /></strong><strong>One PHRF1 gene variant has been associated with elevated IFN-alpha and higher lupus rates.<br /><br /></strong><strong>Simple dietary and lifestyle changes may prevent or improve lupus by targeting your gene variant.</strong></span></p> <p>&nbsp;</p> <h2><strong>PHRF1 &amp; Interferons in Lupus</strong></h2> <p><span style="font-weight: 400;">Scientists are still investigating the exact roles of the </span><a href="https://selfdecode.com/gene/phrf1/"><em><span style="font-weight: 400;">PHRF1</span></em></a><span style="font-weight: 400;"> gene. It likely plays a role in lupus by affecting another nearby gene, </span><a href="https://selfdecode.com/gene/irf7/"><em><span style="font-weight: 400;">IRF7</span></em></a><span style="font-weight: 400;">, which stimulates interferon-alpha (IFN-alpha) production [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18204446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/57661"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IFN-alpha is an inflammatory protein with a central role in lupus development. Lupus patients tend to have elevated IFN-alpha, especially those with more active disease forms. They also have more active interferon-related genes, termed </span><em><span style="font-weight: 400;">interferon signature</span></em><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24834763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/449915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15880830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your PHRF1 Results for Lupus</strong></h2> <p>*9925715783412423*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs4963128/"><strong>rs4963128</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/19838195"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively lower odds of lupus</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase IFN-alpha levels</span></li> </ul> <p>*4360984955747020*</p> <p>&nbsp;</p> <h2><strong>Recommendations for Combating Lupus</strong></h2> <p>*6175387252183437*</p> <h3><strong>Stress Reduction</strong></h3> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/factors-counteract-stress-response/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> may amplify the adverse effects of excess IFN-alpha, and vice versa [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17428549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1255968/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study, daily stress worsened performance in visual memory, visual fluency, and attention in lupus patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17211991/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Stress-management interventions such as cognitive-behavioral therapy or counseling may reduce </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and lupus severity while improving life quality. However, a meta-analysis concluded that the evidence is based on low-quality studies and requires further investigation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199565/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15334437/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20841339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22570339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Psychological stress may worsen the impact of your gene variant on lupus development.</span></p> <h3><strong>Flaxseed</strong></h3> <p><span style="font-weight: 400;">Sufficient dietary intake of omega-3 fatty acids may reduce the negative impact of IFN-alpha administration. This protection likely stems from the anti-inflammatory effects of omega-3s [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24602409/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24182638/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/flaxseed-oil-benefits/"><span style="font-weight: 400;">Flaxseed</span></a><span style="font-weight: 400;"> is the best plant source of omega-3 fatty acids. In two small trials, 30 g of ground flaxseed daily improved kidney function and inflammatory markers in lupus patients [</span><a href="https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7564115/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11349937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Flaxseed may counteract your PHRF1 variants and improve lupus.</span></p> <h3><strong>Vitamin D</strong></h3> <p><span style="font-weight: 400;">According to preliminary research, optimal </span><a href="https://selfhacked.com/blog/vitamin-d-inflammation-autoimmunity/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> status may &lsquo;silence&rsquo; interferon-related genes in lupus patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046063/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25522756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lupus have lower vitamin D levels and are at a higher risk of deficiency, according to several meta-analyses [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31520805/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31468723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29412807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30636593/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one meta-analysis, vitamin D supplementation improved the status of this vitamin and reduced fatigue from lupus, but it didn&rsquo;t reduce lupus severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31331447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with lupus are often vitamin D-deficient and may benefit from supplementation.</span></p>
538 | content_snp_table_9925715783412423_key == 9925715783412423
538 | content_snp_table_9925715783412423_blur == True
538 | content_snp_table_9925715783412423_hidden == False
538 | content_learn_more_4360984955747020_key == 4360984955747020
538 | content_learn_more_4360984955747020_blur == True
538 | content_learn_more_4360984955747020_hidden == False
538 | content_learn_more_4360984955747020_text == Based on the variants we looked at, your PHRF1 gene is associated with slightly higher odds of lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Try to reduce stress and consume more flaxseed to lessen the impact of your variants on lupus. Keep reading to learn more.
538 | content_recommendation_6175387252183437_key == 6175387252183437
538 | content_recommendation_6175387252183437_blur == True
538 | content_recommendation_6175387252183437_hidden == False
rsIDs = rs4963128
rsStatus = rs4963128,PHRF1,chr11,589564,T,A,C,G,3,0,Normal
