539 | id == 539
539 | category_id == 29
539 | category_order == 26
539 | category_name == Lupus
539 | category_color == #C47AC0
539 | slug == CREBL2-lupus
539 | title == The Role of a Gene Regulator in Lupus (CREBL2)
539 | meta_description == CREBL2 may prevent inflammation and autoimmunity. Variants of CREBL2 are linked to lupus. Read more here.
539 | summary == <p style="text-align:justify"><strong>The <em>CREBL2</em> gene is involved in the prevention of inflammation and autoimmunity. Read more to find out how variants of <em>CREBL2</em> may promote the development of the autoimmune disorder lupus.</strong></p>
539 | overall_score_text == Your Lupus Score (based on CREBL2 gene)
539 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CREBL2-GPR19-Lupus.jpg
539 | author_id == 14
539 | author_name == Shany Lahan
539 | author_title == MS (Neuroscience)
539 | author_order == 5
539 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
539 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
539 | reviewer == None
539 | medical_reviewer_id == 11
539 | medical_reviewer_name == Puya Yazdi
539 | medical_reviewer_title == MD
539 | publish_date == 2020
539 | publish_date == 12
539 | publish_date == 8
539 | avg_rating == 5.0
539 | tags_id == 926
539 | tags_name == Autoantibodies
539 | tags_id == 33
539 | tags_name == Autoimmunity
539 | tags_id == 984
539 | tags_name == CREB
539 | tags_id == 1019
539 | tags_name == CREBL2 Gene
539 | tags_id == 393
539 | tags_name == IL-2
539 | tags_id == 24
539 | tags_name == Inflammation
539 | tags_id == 440
539 | tags_name == Th17 Cells
539 | tags_id == 235
539 | tags_name == TNF-alpha
539 | tags_id == 104
539 | tags_name == Tregs
539 | permissions_favorite == False
539 | permissions_rate == False
539 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">CREBL2 </span></em><span style="font-weight: 400;">codes for a protein that interacts with the gene regulator CREB in order to promote its activity. CREB may be involved in preventing autoimmunity and inflammation. Variants of </span><em><span style="font-weight: 400;">CREBL2 </span></em><span style="font-weight: 400;">may play a role in lupus by decreasing CREBL2 production, thereby lowering the activity of CREB. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing CREB activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>CREBL2</em></strong><strong> and Lupus</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/crebl2/"><em><span style="font-weight: 400;">CREBL2</span></em></a> <span style="font-weight: 400;">gene codes for cAMP responsive element-binding protein-like 2 (CREBL2), a protein that may interact with the gene regulator CREB in order to promote its activity [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=1389"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21728997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CREB may help stimulate the production of interleukin-2 (IL-2), an immune system messenger (cytokine) that promotes the development of </span><a href="https://selfhack.com/blog/treg/"><span style="font-weight: 400;">regulatory T cells</span></a><span style="font-weight: 400;"> (</span><a href="https://selfhack.com/blog/treg/"><span style="font-weight: 400;">Tregs</span></a><span style="font-weight: 400;">). Tregs are involved in suppressing the formation of autoantibodies, or antibodies that recognize the body&rsquo;s own tissues. In this manner, Tregs may function to prevent lupus and other autoimmune disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519339/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15307180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342324/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">IL-2 also helps prevent the production of T helper 17 (</span><a href="https://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17</span></a><span style="font-weight: 400;">) immune system cells. Th17 cells release inflammatory cytokines that may be involved in the progression of organ damage in lupus, such as </span><a href="https://selfhack.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100298/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8948291/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9034987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">CREBL2 </span></em><span style="font-weight: 400;">have been associated with lupus. These variants may decrease the production of CREBL2, leading to reduced activity of CREB, decreased production of IL-2, autoantibody formation, and inflammation [</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>CREBL2</em></strong><strong> Results for Lupus</strong></h2> <p style="text-align: justify;">*7287130960179373*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>CREBL2 </em></strong><a href="https://selfdecode.com/snp/rs10845606/"><strong>rs10845606</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26502338"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of lupus, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of lupus, relative to &lsquo;C&rsquo;&nbsp;</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>CREBL2 </em></strong><a href="https://selfdecode.com/snp/rs12822507/"><strong>rs12822507</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/23273568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of lupus, relative to &lsquo;G&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Lower odds of lupus, relative to &lsquo;A&rsquo;&nbsp;</span></li> </ul> <p style="text-align: justify;">*5306750586103373*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Lupus</strong></h2> <p style="text-align: justify;">*2170795669559206*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Acupuncture</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies have demonstrated that </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> may increase the activity of CREB [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25481359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412208/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Acupuncture may also help relieve muscle </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> associated with lupus. In a small trial of lupus patients, standard care failed to reduce pain, while a 10-session course of acupuncture reduced pain by at least 30% in the 40% of patients who received it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633212/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may help manage lupus by increasing the activity of CREB.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Green Tea</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">A number of compounds in </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;"> have been found to promote the activity of CREB, suggesting that green tea may be beneficial for individuals carrying risk variants of </span><em><span style="font-weight: 400;">CREBL2 </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627400/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30371539/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial of people with lupus, 1000 mg per day of a green tea extract containing 22% polyphenols (equivalent to one cup of green tea) for 12 weeks improved disease severity and quality of life [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28585735/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Green tea may help manage lupus by increasing the activity of CREB.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>DHEA&nbsp;</strong></h4> <p style="text-align: justify;"><em><span style="font-weight: 400;">DHEA should never be used without the prescription or recommendation of a medical professional. Talk to your doctor before using DHEA for any purpose.</span></em></p> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/dhea-dhea-s/"><span style="font-weight: 400;">DHEA</span></a><span style="font-weight: 400;"> increased the activity of CREB in multiple cell- and animal-based studies. In one of these studies, the DHEA-mediated increase in CREB activity was linked to reduced inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22523357/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/33083624/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28894299/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementation with DHEA reduced lupus severity, flares, bone loss from corticosteroids, the need for this medication, and an immune protein (</span><a href="http://selfhacked.com/blog/il-10/"><span style="font-weight: 400;">IL-10</span></a><span style="font-weight: 400;">), all while improving quality of life, in 10 clinical trials of people with active, mild-to-moderate lupus [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7945493/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8849355/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9858429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9489820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12428233/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12124866/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754850/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15452837/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15801015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16373258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18634158/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, it didn&rsquo;t help prevent clogged arteries or osteoporosis, worsened blood fat profile, and showed no benefits in people with severe or inactive lupus. A meta-analysis concluded that it may only have short-term benefits on quality of life [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20530522/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15529389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10342710/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19854713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17943841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">DHEA may help manage lupus by increasing the activity of CREB.</span></p>
539 | content_snp_table_7287130960179373_key == 7287130960179373
539 | content_snp_table_7287130960179373_blur == True
539 | content_snp_table_7287130960179373_hidden == False
539 | content_learn_more_5306750586103373_key == 5306750586103373
539 | content_learn_more_5306750586103373_blur == True
539 | content_learn_more_5306750586103373_hidden == False
539 | content_learn_more_5306750586103373_text == Based on the variants we looked at, your CREBL2 gene is associated with somewhat higher odds of lupus, relative to other variants. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Acupuncture, green tea, and DHEA supplements may help. Keep scrolling to find out more.
539 | content_recommendation_2170795669559206_key == 2170795669559206
539 | content_recommendation_2170795669559206_blur == True
539 | content_recommendation_2170795669559206_hidden == False
rsIDs = rs12822507,rs10845606
rsStatus = rs12822507,CREBL2,chr12,12620587,A,C,G,,31,0,Normal
rsStatus = rs10845606,GPR19,chr12,12681960,C,A,G,T,31,0,Normal
