545 | id == 545
545 | category_id == 30
545 | category_order == 27
545 | category_name == Hair Loss
545 | category_color == #C47AC0
545 | slug == RREB1-male-pattern-baldness
545 | title == Hair Growth Cycle Regulation & Male-Pattern Baldness (RREB1)
545 | meta_description == RREB1 helps regulate hair growth. A variant of RREB1 is linked to male-pattern baldness. Read more here.
545 | summary == <p style="text-align:justify"><strong>The <em>RREB1</em> gene may help regulate hair growth by modulating the activity of a protein crucial for cell proliferation. How might a variant of <em>RREB1</em> alter this function and promote the development of male-pattern baldness? Read more to find out.</strong></p>
545 | overall_score_text == Your Hair Loss Score (based on RREB1 gene)
545 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RREB1-Male-pattern-baldness_1.jpg
545 | author_id == 14
545 | author_name == Shany Lahan
545 | author_title == MS (Neuroscience)
545 | author_order == 5
545 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
545 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
545 | reviewer == None
545 | medical_reviewer_id == 11
545 | medical_reviewer_name == Puya Yazdi
545 | medical_reviewer_title == MD
545 | publish_date == 2020
545 | publish_date == 12
545 | publish_date == 12
545 | avg_rating == 5.0
545 | tags_id == 1032
545 | tags_name == Hair Follicle
545 | tags_id == 1033
545 | tags_name == Hair Growth Cycle
545 | tags_id == 1029
545 | tags_name == Hair Loss
545 | tags_id == 1028
545 | tags_name == Male-Pattern Baldness
545 | tags_id == 1035
545 | tags_name == Ras
545 | tags_id == 1034
545 | tags_name == RREB1 Gene
545 | permissions_favorite == False
545 | permissions_rate == False
545 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">codes for a protein that regulates genes involved in the hair growth cycle, partly by modulating the activity of Ras. A variant of </span><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by dysregulating </span><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">production and Ras activity. Lifestyle and diet modifications may counteract the effects of this variant by preventing further increases in Ras.</span></span></p> <h2 style="text-align: justify;"><strong><em>RREB1</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">gene codes for Ras responsive element-binding protein 1 (RREB-1). Studies have shown that RREB-1 may act in concert with other proteins to turn genes on or off, depending on the gene, cell type, and context [</span><a href="https://www.ncbi.nlm.nih.gov/gene/6239"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15067362/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12482979/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9187140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">RREB-1-induced gene regulation may partly be mediated by Ras, a family of signaling proteins [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17550981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24906326/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Ras activity may be essential for regulating genes involved in the hair growth cycle, in which hair grows within a follicle, detaches from the follicle, and falls out. It&rsquo;s been suggested that Ras proteins may specifically become activated during hair growth and inactivated during hair detachment [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK470321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, studies have demonstrated that both over- and underactivity of Ras perturb the hair growth cycle and promote progressive hair loss. This suggests that balanced Ras activity is essential for maintaining hair integrity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">has been associated with male-pattern baldness. While the mechanism is unclear, it&rsquo;s possible that this variant may alter RREB-1 production or activity, resulting in Ras dysregulation and hair cycle perturbation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/28196072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>RREB1 </em></strong><strong>Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*8812721647832242*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>RREB1 </em></strong><a href="https://selfdecode.com/snp/rs675209/"><strong>rs675209</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/28196072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;">*4633850989305472*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*7942378243527308*</p> <p style="text-align: justify;"><span style="font-weight: 400;">It&rsquo;s important to note that mutations in Ras are linked to cancer. These mutations result in Ras overactivity, which may lead to the excessive growth and expansion (proliferation) of cells. Interestingly, hair follicles may have multiple ways of suppressing these mutations in order to prevent cancer progression in the follicle [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">As the recommendations below have been shown to be advantageous in the management of male-pattern baldness by preventing further increases in Ras, they may also be beneficial to the prevention of cancer. However, it&rsquo;s important to speak with your doctor before making any significant changes to your lifestyle, diet, or supplements -- especially if you may be at increased risk of cancer.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Cigarettes</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cigarettes are well known to excessively stimulate Ras. Smoking cigarettes may therefore worsen Ras dysregulation in individuals carrying risk variants of </span><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/22240207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556819/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Several studies have associated smoking with an approximately 2-fold increased risk of male-pattern baldness. Cigarette smoke may cause oxidative and inflammatory damage in the hair follicles, impair hair growth, and reduce female sex hormone levels. A study found that the combination of smoking with being overweight increased male-pattern baldness severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12673073/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28555720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18025364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32946667/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23629119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarettes may excessively stimulate Ras. Avoiding cigarettes may help manage male-pattern baldness by preventing excessive increases in Ras levels.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Maintain a Healthy Weight</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies have reported that unhealthy weight gain (linked to being overweight or obese) may excessively stimulate Ras, suggesting that not maintaining a healthy weight may worsen the effects of </span><em><span style="font-weight: 400;">RREB1 </span></em><span style="font-weight: 400;">risk variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29079305/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32304665/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Being overweight or obese has also been associated with increased severity of male-pattern baldness, especially if combined with high BMI [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24184140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28555720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24746780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Being overweight or obese may excessively stimulate Ras. Maintaining a healthy weight may help manage male-pattern baldness by preventing excessive increases in Ras levels.</span></p>
545 | content_snp_table_8812721647832242_key == 8812721647832242
545 | content_snp_table_8812721647832242_blur == True
545 | content_snp_table_8812721647832242_hidden == False
545 | content_learn_more_4633850989305472_key == 4633850989305472
545 | content_learn_more_4633850989305472_blur == True
545 | content_learn_more_4633850989305472_hidden == False
545 | content_learn_more_4633850989305472_text == Based on the variants we looked at, your RREB1 gene is associated with somewhat higher odds of male-pattern baldness, relative to other variants. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. Avoiding cigarettes and maintaining a healthy weight may help. Keep scrolling to find out more.
545 | content_recommendation_7942378243527308_key == 7942378243527308
545 | content_recommendation_7942378243527308_blur == True
545 | content_recommendation_7942378243527308_hidden == False
rsIDs = rs675209
rsStatus = rs675209,,chr6,7101851,T,C,,,15,8,HET
