546 | id == 546
546 | category_id == 29
546 | category_order == 26
546 | category_name == Lupus
546 | category_color == #C47AC0
546 | slug == NCF2-NADPH-lupus
546 | title == How Oxidation Protects Against Lupus (NCF2)
546 | meta_description == The NCF2 gene codes for an enzyme that helps maintain a healthy immune response. Learn about its link with lupus.
546 | summary == <p style="text-align:justify"><strong>Did you know that oxidative stress has a good side and may protect against lupus? Read this post to learn the role of the <em>NCF2 </em>gene in this process and get personalized recommendations.</strong></p>
546 | overall_score_text == Your Lupus Score (based on NCF2 gene)
546 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SMG7-NCF2-Lupus.jpg
546 | author_id == 9
546 | author_name == Aleksa Ristic
546 | author_title == MS (Pharmacy)
546 | author_order == 45
546 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
546 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
546 | reviewer == None
546 | medical_reviewer_id == 11
546 | medical_reviewer_name == Puya Yazdi
546 | medical_reviewer_title == MD
546 | publish_date == 2020
546 | publish_date == 12
546 | publish_date == 12
546 | avg_rating == 5.0
546 | tags_id == 33
546 | tags_name == Autoimmunity
546 | tags_id == 84
546 | tags_name == Lupus
546 | tags_id == 1037
546 | tags_name == NADPH oxidase
546 | tags_id == 1036
546 | tags_name == NCF2 gene
546 | tags_id == 39
546 | tags_name == Oxidative Stress
546 | permissions_favorite == False
546 | permissions_rate == False
546 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The </strong><strong><em>NCF2</em></strong><strong> gene codes for NADPH oxidase, an enzyme that helps maintain a healthy immune response.<br /><br /></strong><strong>Specific </strong><strong><em>NCF2</em></strong><strong> variants correlate with lower NADPH oxidase activity and higher lupus rates.<br /><br /></strong><strong>This post reveals potential ways to improve lupus by targeting </strong><strong><em>NCF2</em></strong><strong> gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The NCF2 Gene in Lupus Development</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ncf2/"><em><span style="font-weight: 400;">NCF2</span></em></a><span style="font-weight: 400;"> gene helps make </span><a href="https://selfhacked.com/blog/nicotinamide-adenine-dinucleotide-phosphate-nadph/"><span style="font-weight: 400;">NADPH</span></a><a href="https://www.selfdecode.com/gene/CYBA/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;"> oxidase</span></a><span style="font-weight: 400;"> (NADPHO or NOX). This enzyme turns NADPH into NADP+ and creates reactive oxygen species (ROS). Although ROS are typically associated with </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;">, they are essential in certain amounts to kill microbes and control the cell&rsquo;s life cycle [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929085/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109634"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">NADPHO-deficient mice develop severe lupus. According to research, the lack of ROS impairs the removal of microbes and damaged cells, which then creates toxic waste and contributes to autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23100627/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your NCF2 Results for Lupus</strong></h2> <p>*5167181834892736*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs17849501/"><strong>rs17849501</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/ng.3434"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively lower lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces NADPH oxidase activity.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs13306575/"><strong>rs13306575</strong></a> <span style="font-weight: 400;">[</span><a href="https://europepmc.org/article/med/26606652"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively higher lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively lower lupus rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely reduces NADPH oxidase activity.</span></li> </ul> <p>*7052044215227937*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent &amp; Improve Lupus</strong></h2> <p>*3734310390718209*</p> <h3><strong>Exercise</strong></h3> <p><span style="font-weight: 400;">In animal experiments, </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> increased NADPH oxidase activity. This enzyme may be a key factor for certain beneficial effects of physical activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18006481/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307857/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis involving 469 people with lupus concluded that aerobic exercise may improve fatigue, </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">, and physical fitness without worsening disease activity. People with mild lupus should practice moderate-intensity exercise for at least 20 minutes, 3 days/week [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28477898/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28432856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aerobic exercise may lessen the impact of your NCF2 variants on lupus development.</span></p> <h3><strong>Niacin</strong></h3> <p><a href="http://selfhacked.com/blog/top-science-based-health-benefits-vitamin-b3-niacin/"><span style="font-weight: 400;">Niacin</span></a><span style="font-weight: 400;"> or vitamin B3 exists in two different forms: nicotinamide and nicotinic acid. Nicotinamide builds </span><a href="https://selfhacked.com/blog/nicotinamide-adenine-dinucleotide-phosphate-nadph/"><span style="font-weight: 400;">NADP+/NADPH</span></a><span style="font-weight: 400;"> and thus maintains the function of NADPH oxidase [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25399625"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18020963"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to different clinical trials, niacin supplementation may improve blood lipids by reducing </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/ldl-cholesterol/"><span style="font-weight: 400;">LDL</span></a><span style="font-weight: 400;">, while boosting </span><a href="https://www.selfhacked.com/blog/hdl-cholesterol/"><span style="font-weight: 400;">HDL</span></a><span style="font-weight: 400;"> cholesterol [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27063258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804877/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22085343"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24806747"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24768191"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lupus tend to have high blood triglycerides and </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;">, leading to increased risk of premature heart disease. Hence, lipid-lowering interventions such as niacin may be a good choice, especially in those carrying NCF2 variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7783060/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12375321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14705221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29320971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Niacin supplementation may improve lupus by targeting your gene variant.</span></p>
546 | content_snp_table_5167181834892736_key == 5167181834892736
546 | content_snp_table_5167181834892736_blur == True
546 | content_snp_table_5167181834892736_hidden == False
546 | content_learn_more_7052044215227937_key == 7052044215227937
546 | content_learn_more_7052044215227937_blur == True
546 | content_learn_more_7052044215227937_hidden == False
546 | content_learn_more_7052044215227937_text == Based on the variants we looked at, your NCF2 gene is associated with relatively higher odds of lupus. However, this doesn't necessarily reflect your overall risk of lupus; it’s just one gene related to it. Exercise regularly and consider supplementing with niacin to lessen the impact of your variants on lupus. Keep reading to learn more.
546 | content_recommendation_3734310390718209_key == 3734310390718209
546 | content_recommendation_3734310390718209_blur == True
546 | content_recommendation_3734310390718209_hidden == False
rsIDs = rs13306575,rs17849501
rsStatus = rs13306575,NCF2,chr1,183563302,G,A,C,T,34,0,Normal
rsStatus = rs17849501,NCF2,chr1,183573188,C,T,,,47,0,Normal
