549 | id == 549
549 | category_id == 30
549 | category_order == 27
549 | category_name == Hair Loss
549 | category_color == #C47AC0
549 | slug == EDAR-male-pattern-baldness
549 | title == A Gene Essential for Hair Development & Its Role in Male-Pattern Baldness (EDAR)
549 | meta_description == EDAR is essential for hair development. A variant of EDAR has been associated with male-pattern baldness. Read more here.
549 | summary == <p style="text-align:justify"><strong><em>EDAR</em> codes for a protein that may be essential for hair development. How might a variant of <em>EDAR</em> alter hair development and promote male-pattern baldness? Read more to find out.</strong></p>
549 | overall_score_text == Your Hair Loss Score (based on EDAR gene)
549 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/EDAR-Male-pattern-baldness.jpg
549 | author_id == 14
549 | author_name == Shany Lahan
549 | author_title == MS (Neuroscience)
549 | author_order == 5
549 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
549 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
549 | reviewer == None
549 | medical_reviewer_id == 11
549 | medical_reviewer_name == Puya Yazdi
549 | medical_reviewer_title == MD
549 | publish_date == 2020
549 | publish_date == 12
549 | publish_date == 14
549 | avg_rating == 5.0
549 | tags_id == 1040
549 | tags_name == Ectoderm
549 | tags_id == 1039
549 | tags_name == EDAR Gene
549 | tags_id == 1032
549 | tags_name == Hair Follicle
549 | tags_id == 1029
549 | tags_name == Hair Loss
549 | tags_id == 1041
549 | tags_name == Hypohidrotic Ectodermal Dysplasia
549 | tags_id == 1028
549 | tags_name == Male-Pattern Baldness
549 | tags_id == 369
549 | tags_name == NF-κB
549 | permissions_favorite == False
549 | permissions_rate == False
549 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">EDAR</span></em><span style="font-weight: 400;"> encodes a protein that stimulates NF-kB, thereby promoting hair development. A variant of </span><em><span style="font-weight: 400;">EDAR </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by producing dysfunctional EDAR and significantly lowering the production of NF-kB. Lifestyle and diet modifications may counteract the effects of this variant by slightly boosting or preventing a decrease in NF-kB activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>EDAR </em></strong><strong>and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://www.ncbi.nlm.nih.gov/gene/10913"><em><span style="font-weight: 400;">EDAR</span></em></a> <span style="font-weight: 400;">gene codes for ectodysplasin A receptor (EDAR). As its name suggests, EDAR binds ectodysplasin A, a protein essential for the development of the outermost layer of cells in the body (ectoderm). The development of the ectoderm gives rise to structures such as skin, nails, teeth, and hair [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10913"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, rare mutations in the </span><em><span style="font-weight: 400;">EDAR </span></em><span style="font-weight: 400;">gene may result in dysfunctional EDAR and abnormal ectoderm development. These mutations have been linked to <em>hypohidrotic ectodermal dysplasia</em>, a genetic disorder characterized by dry skin, reduced number of teeth, and sparse hair [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036832/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17501952/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, the activation of EDAR has been reported to stimulate </span><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a><span style="font-weight: 400;">. Although NF-kB is a well-known inflammatory protein, its activity may also be important for the development of hair follicles, in which NF-kB may specifically promote cell survival [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24508088/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11585809/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">EDAR </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. These variants may produce dysfunctional EDAR, which may lower the activation of NF-kB and promote hair loss</span> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41467-018-07862-y"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>EDAR</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*6547240131421431*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>EDAR </em></strong><a href="https://selfdecode.com/snp/rs3827760/"><strong>rs3827760</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41467-018-07862-y"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;G&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;">*9461657284321809*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*9336778391144955*</p> <p style="text-align: justify;"><span style="font-weight: 400;">Note that attempting to significantly raise levels or activity of NF-kB is not recommended, due to its role in inflammation. The recommendations below offer ways to slightly boost or prevent a decrease in NF-kB, while helping to manage male-pattern baldness.</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Low-Level Laser Therapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">) is the application of low-power lasers to the surface of the body. It seems to stimulate the production of nitric oxide and free radicals, both of which act as messenger molecules to trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In some cell types, LLLT has been demonstrated to promote cell survival by increasing production and activity of NF-kB [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141042/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523874/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29722183/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The FDA approved this technique for male-pattern baldness in 2007. Meta-analyses of 11 different trials suggest that LLLT may improve hair growth and density, both alone and in combination with conventional treatments. However, they warned that larger studies with longer follow-up periods and independent sources of funding are required to confirm these results [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Low-level laser therapy (LLLT) may help manage male-pattern baldness by stimulating NF-kB.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Eating Sufficient Proteins</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Low protein intake may suppress NF-kB by decreasing the activity of a hormone known to boost this protein [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19861158/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988204/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of people with hair loss, most of the subjects with male-pattern baldness had deficiencies of the essential amino acids </span><a href="https://www.selfhacked.com/blog/histidine/"><span style="font-weight: 400;">histidine</span></a><span style="font-weight: 400;">, </span><a href="https://www.selfhacked.com/blog/leucine-health-benefits-side-effects/"><span style="font-weight: 400;">leucine</span></a><span style="font-weight: 400;">, and isoleucine. Dietary sources of these amino acids include protein-rich foods such as meat, fish, dairy products, eggs, and legumes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596642/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Eating sufficient proteins may help manage male-pattern baldness by preventing a decrease in NF-kB activity.&nbsp;&nbsp;</span></p>
549 | content_snp_table_6547240131421431_key == 6547240131421431
549 | content_snp_table_6547240131421431_blur == True
549 | content_snp_table_6547240131421431_hidden == False
549 | content_learn_more_9461657284321809_key == 9461657284321809
549 | content_learn_more_9461657284321809_blur == True
549 | content_learn_more_9461657284321809_hidden == False
549 | content_learn_more_9461657284321809_text == Based on the variants we looked at, your EDAR gene is associated with somewhat lower rates of male-pattern baldness, relative to other variants. However, other genes and health factors may still contribute to your risk.
549 | content_recommendation_9336778391144955_key == 9336778391144955
549 | content_recommendation_9336778391144955_blur == True
549 | content_recommendation_9336778391144955_hidden == False
rsIDs = rs3827760
rsStatus = rs3827760,EDAR,chr2,108897145,A,C,G,,41,0,Normal
