550 | id == 550
550 | category_id == 30
550 | category_order == 27
550 | category_name == Hair Loss
550 | category_color == #C47AC0
550 | slug == WNT10A-baldness
550 | title == The Wnt Signalling Pathway in Male-Pattern Baldness (WNT10A)
550 | meta_description == The WNT10A gene is part of a pathway that regulates the development of the skin. How is it linked to male-pattern baldness?
550 | summary == <p><strong>The <em>WNT10A </em>gene is part of a pathway that regulates the development of the skin. How is it linked to male-pattern baldness? Find out here.</strong></p>
550 | overall_score_text == Your Hair Loss Score (based on WNT10A)
550 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/WNT10A-Male-pattern-baldness.jpg
550 | author_id == 1
550 | author_name == Jasmine Foster
550 | author_title == BSc, BEd
550 | author_order == 36
550 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
550 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
550 | reviewer == None
550 | medical_reviewer_id == 11
550 | medical_reviewer_name == Puya Yazdi
550 | medical_reviewer_title == MD
550 | publish_date == 2020
550 | publish_date == 12
550 | publish_date == 14
550 | avg_rating == 5.0
550 | tags_id == 1032
550 | tags_name == Hair Follicle
550 | tags_id == 1033
550 | tags_name == Hair Growth Cycle
550 | tags_id == 1029
550 | tags_name == Hair Loss
550 | tags_id == 1028
550 | tags_name == Male-Pattern Baldness
550 | tags_id == 776
550 | tags_name == Skin health
550 | tags_id == 1043
550 | tags_name == WNT10A Gene
550 | tags_id == 1031
550 | tags_name == Wnt Signalling
550 | permissions_favorite == False
550 | permissions_rate == False
550 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">WNT10A</span></em><span style="font-weight: 400;"> encodes wingless-type MMTV integration site family member 10A. Variants of </span><em><span style="font-weight: 400;">WNT10A</span></em><span style="font-weight: 400;"> may play a role in male-pattern baldness by disrupting hair follicle formation or the hair growth cycle. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by supporting correct wnt signalling.</span></p> <h2><strong><em>WNT10A</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/wnt10a/"><em><span style="font-weight: 400;">WNT10A</span></em></a><span style="font-weight: 400;"> gene encodes a protein called wingless-type MMTV integration site family, member 10A. This protein is abundant in the skin and has been implicated in a number of different types of cancer [</span><a href="https://www.jidonline.org/article/S0022-202X(15)36283-7/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/80326"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">WNT10A</span></em><span style="font-weight: 400;"> is believed to play an important role in the development of hair follicles and in the growth cycle of hair. This gene has been implicated in a group of disorders called ectodermal dysplasias [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706962/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.jidonline.org/article/S0022-202X(15)36283-7/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Patients with ectodermal dysplasias typically have symptoms associated with dysregulated or faulty skin and tooth structures, including [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1973944/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://rarediseases.info.nih.gov/diseases/6317/ectodermal-dysplasia"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Abnormal teeth</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Abnormal fingernails</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Brittle or absent hair</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Inability to sweat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Other skin problems</span></li> </ul> <p><span style="font-weight: 400;">Given its participation in hair follicle development and its association with ectodermal dysplasia, it&rsquo;s not surprising that </span><em><span style="font-weight: 400;">WNT10A</span></em><span style="font-weight: 400;"> variants have been associated with male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms14694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">WNT10A</span></em><span style="font-weight: 400;"> gene is part of the wnt signalling pathway that regulates the development and maintenance of skin, teeth, fingernails, and hair. Reduced wnt signalling may increase susceptibility to hair loss.</span></span></p> <h2><strong>Your </strong><strong><em>WNT10A</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p>*7749249525662907*</p> <p><a href="https://selfdecode.com/gene/wnt10a/"><strong>WNT10A</strong></a> <a href="https://selfdecode.com/snp/rs74333950/"><strong>rs74333950</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms14694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with increased rates of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may interfere with the development of hair follicles or interrupt the hair growth cycle [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706962/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.jidonline.org/article/S0022-202X(15)36283-7/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/wnt10a/"><strong>WNT10A</strong></a> <a href="https://selfdecode.com/snp/rs7349332/"><strong>rs7349332</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41467-018-07862-y"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with increased rates of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may interfere with the development of hair follicles or interrupt the hair growth cycle [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706962/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.jidonline.org/article/S0022-202X(15)36283-7/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*2412287701967943*</p> <h2><strong>Recommendations for Improving Hair Growth</strong></h2> <p>*2484946468018152*</p> <h3><strong>LLLT</strong></h3> <p><span style="font-weight: 400;">Low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">) is the application of low-power lasers to the surface of the body. LLLT is believed to help stimulate hair growth through the wnt signalling pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28508243/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">LLLT seems to stimulate the production of NO and free radicals, both of which act as messenger molecules to trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The FDA approved this technique for male-pattern baldness in 2007. Meta-analyses of 11 different placebo-controlled trials suggest that LLLT may improve hair growth and density, both alone and in combination with conventional treatments. However, they warned that larger studies with longer follow-up periods and independent sources of funding are required to confirm these results [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">LLLT may promote hair growth through the wnt signalling pathway.</span></p> <h3><strong>Zinc</strong></h3> <p><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">Zinc</span></a><span style="font-weight: 400;"> may help support the wnt signalling pathway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25912432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study of 120 men found that those with male-pattern baldness had lower blood levels of </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/biotin/"><span style="font-weight: 400;">vitamin B7</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30714301/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In another study of 48 men with this condition, normal blood zinc levels were associated with better success of conservative therapies and increased hair density [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277952/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Good dietary sources of zinc include red meat, seafood, dairy products, nuts, legumes, and whole grains [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11053529/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc may support the wnt signalling pathway. This could help explain why people with higher zinc levels tend to have higher hair density.</span></p> <h3><strong>L-Carnitine</strong></h3> <p><span style="font-weight: 400;">Exposure to </span><a href="https://selfhacked.com/blog/carnitine-top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">L-carnitine</span></a><span style="font-weight: 400;"> enhanced wnt signalling in stem cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367658/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a placebo-controlled trial of 60 men and women with baldness caused by male sex hormones, topical application of a solution with 2% L-</span><a href="https://selfhacked.com/blog/carnitine-top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">carnitine</span></a><span style="font-weight: 400;"> for 6 months increased hair density and the proportion of hairs in the active growth phase. L-carnitine promoted hair follicle cell growth while preventing their death [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17804203/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17927577/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In an uncontrolled trial of 60 men and women, two similar commercial solutions with L-carnitine, </span><a href="https://selfhacked.com/blog/gamma-linolenic-acid/"><span style="font-weight: 400;">gamma-linolenic acid</span></a><span style="font-weight: 400;">, and a compound from soybean (equol) increased both hair count and the proportion of hairs in the active growth phase after 1-6 months of application [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30371981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">L-carnitine increased wnt signalling in a cell study. Through this pathway, it may help increase hair density.</span></p>
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550 | content_learn_more_2412287701967943_text == Based on the variants we looked at, your WNT10A gene is somewhat associated with susceptibility to hair loss. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. LLLT, zinc, and L-carnitine may help. Keep scrolling to find out more.
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rsIDs = rs74333950,rs7349332
rsStatus = rs74333950,WNT10A,chr2,218881570,T,G,,,26,0,Normal
rsStatus = rs7349332,WNT10A,chr2,218891661,C,G,T,,24,1,HET
