554 | id == 554
554 | category_id == 30
554 | category_order == 27
554 | category_name == Hair Loss
554 | category_color == #C47AC0
554 | slug == PTHLH-male-pattern-baldness
554 | title == Accelerated Hair Growth Cycles & Male-Pattern Baldness (PTHLH)
554 | meta_description == PTHLH helps regulate hair growth. Variants of PTHLH have been associated with male-pattern baldness. Read more here.
554 | summary == <p style="text-align:justify"><strong><em>PTHLH</em> codes for a protein that helps regulate hair growth. How might <em>PTHLH</em> variants increase the odds of male-pattern baldness? Read more to find out.</strong></p>
554 | overall_score_text == Your Hair Loss Score (based on PTHLH gene)
554 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PTHLH-Male-pattern-baldness.jpg
554 | author_id == 14
554 | author_name == Shany Lahan
554 | author_title == MS (Neuroscience)
554 | author_order == 5
554 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
554 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
554 | reviewer == None
554 | medical_reviewer_id == 11
554 | medical_reviewer_name == Puya Yazdi
554 | medical_reviewer_title == MD
554 | publish_date == 2020
554 | publish_date == 12
554 | publish_date == 16
554 | avg_rating == 5.0
554 | tags_id == 1045
554 | tags_name == Beta-Catenin
554 | tags_id == 372
554 | tags_name == Blood vessels
554 | tags_id == 1032
554 | tags_name == Hair Follicle
554 | tags_id == 1033
554 | tags_name == Hair Growth Cycle
554 | tags_id == 1029
554 | tags_name == Hair Loss
554 | tags_id == 1046
554 | tags_name == LEF-1
554 | tags_id == 1028
554 | tags_name == Male-Pattern Baldness
554 | tags_id == 1044
554 | tags_name == PTHLH Gene
554 | tags_id == 1049
554 | tags_name == Wnt
554 | tags_id == 1031
554 | tags_name == Wnt Signalling
554 | permissions_favorite == False
554 | permissions_rate == False
554 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">PTHLH </span></em><span style="font-weight: 400;">codes for a protein that helps accelerate hair growth by activating beta-catenin and LEF-1. Variants of </span><em><span style="font-weight: 400;">PTHLH </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by dysregulating PTHLH and decreasing beta-catenin and LEF-1 production. Lifestyle and supplement modifications may counteract the effects of these variants by increasing the production of beta-catenin and LEF-1.</span></span></p> <h2 style="text-align: justify;"><strong><em>PTHLH</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/pthlh/"><em><span style="font-weight: 400;">PTHLH</span></em></a> <span style="font-weight: 400;">gene codes for parathyroid hormone-like hormone (PTHLH), a protein that suppresses the growth and expansion (proliferation) of cells. In hair follicles, the production of PTHLH must be tightly regulated in order to maintain proper hair growth cycles [</span><a href="https://www.ncbi.nlm.nih.gov/gene/5744"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25721772/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25041375/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Hair growth cycles include cell proliferation (hair growing), follicle regression (hair detaching), and rest (hair falling out). In line with its ability to suppress cell proliferation, PTHLH levels have been observed to steadily rise over the course of hair growth, and reach their peak prior to hair detachment [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25721772/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25041375/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Studies have shown that this effect may be due to prevention of blood vessel formation by PTHLH. Blood vessels provide hair follicle cells with oxygen, nutrients, and other factors essential for their growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16675960/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10771470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, PTHLH may also be necessary for transitioning follicles from rest to proliferation, suggesting a general role for this hormone in stimulating and accelerating the hair growth cycle. The transition from rest to proliferation may be dependent on proteins beta-catenin and LEF-1 (part of the <a href="https://selfdecode.com/blog/article/WNT10A-baldness-550/">Wnt signaling pathway</a>) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25041375/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11171335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11371349/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">PTHLH </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. These variants may dysregulate the production of PTHLH, resulting in lower beta-catenin and LEF-1 levels and hair cycle perturbation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms14694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25721772/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25041375/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>PTHLH</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*7932413757395884*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>PTHLH </em></strong><a href="https://selfdecode.com/snp/rs805512/"><strong>rs805512</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>PTHLH </em></strong><a href="https://selfdecode.com/snp/rs10843026/"><strong>rs10843026</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms14694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;G&rsquo;</span></li> </ul> <p style="text-align: justify;">*5480292524075816*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*3977960454166474*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Low-Level Laser Therapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">) is the application of low-power lasers to the surface of the body. It seems to stimulate the production of nitric oxide and free radicals, both of which act as messenger molecules to trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In cell- and animal-based studies, LLLT was also shown to stimulate hair growth by increasing production of beta-catenin and LEF-1 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28508243/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29468283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28944964/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29200764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The FDA approved this technique for male-pattern baldness in 2007. Meta-analyses of 11 different trials suggest that LLLT may improve hair growth and density, both alone and in combination with conventional treatments. However, they warned that larger studies with longer follow-up periods and independent sources of funding are required to confirm these results [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Low-level laser therapy may help manage male-pattern baldness by stimulating beta-catenin and LEF-1 production.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Adenosine</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;"><a href="https://selfhacked.com/blog/adenosine-health-effects/" target="_blank" rel="noopener">Adenosine</a> was found to lengthen the cell proliferation phase of hair follicles and subsequently promote hair growth, in part by increasing the production of beta-catenin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22020741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Topical </span><span style="font-weight: 400;">adenosine</span><span style="font-weight: 400;"> applied for 6 months increased the proportion of thick hair in two trials of men with male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25925959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26508659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In another trial of men with male-pattern baldness, a topical solution with 0.75% adenosine was as effective as minoxidil (a conventional medication) at recovering hair growth. Moreover, patients were more satisfied with adenosine because they perceived faster reduction of hair loss and growth of new hairs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24183218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical adenosine may help manage male-pattern baldness by stimulating beta-catenin production.</span></p> <h4 style="text-align: justify;"><strong>Rice Bran</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Topical rice bran mineral extract was suggested to stimulate hair growth by promoting the production and activity of beta-catenin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727428/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a trial of men with male-pattern baldness, rice bran extract applied to the scalp for 16 weeks increased hair density and diameter [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26632177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This extract, especially its active components linoleic acid and gamma-oryzanol, induced hair growth and the development of hair follicles in mice [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24389480/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical rice bran may help manage male-pattern baldness by stimulating beta-catenin production and activity.</span></p>
554 | content_snp_table_7932413757395884_key == 7932413757395884
554 | content_snp_table_7932413757395884_blur == True
554 | content_snp_table_7932413757395884_hidden == False
554 | content_learn_more_5480292524075816_key == 5480292524075816
554 | content_learn_more_5480292524075816_blur == True
554 | content_learn_more_5480292524075816_hidden == False
554 | content_learn_more_5480292524075816_text == Based on the variants we looked at, your PTHLH gene is associated with somewhat lower odds of male-pattern baldness, relative to other variants. However, other genes and health factors may still contribute to your risk.
554 | content_recommendation_3977960454166474_key == 3977960454166474
554 | content_recommendation_3977960454166474_blur == True
554 | content_recommendation_3977960454166474_hidden == False
rsIDs = rs10843026,rs805512
rsStatus = rs10843026,,chr12,27940679,G,A,,,26,0,Normal
rsStatus = rs805512,PTHLH,chr12,27965914,C,A,G,T,10,9,HET
