556 | id == 556
556 | category_id == 30
556 | category_order == 27
556 | category_name == Hair Loss
556 | category_color == #C47AC0
556 | slug == PRDM1-male-pattern-baldness
556 | title == A Wnt Signaling Regulator & Its Role in Male-Pattern Baldness (PRDM1)
556 | meta_description == PRDM1 helps regulate hair growth. Variants of PRDM1 have been associated with male-pattern baldness. Read more here.
556 | summary == <p style="text-align:justify"><strong><em>PRDM1 </em>codes for a protein that helps regulate hair growth. How might <em>PRDM1 </em>variants increase the odds of male-pattern baldness? Read more to find out.</strong></p>
556 | overall_score_text == Your Hair Loss Score (based on PRDM1 gene)
556 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PRDM1-Male-pattern-baldness.jpg
556 | author_id == 14
556 | author_name == Shany Lahan
556 | author_title == MS (Neuroscience)
556 | author_order == 5
556 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
556 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
556 | reviewer == None
556 | medical_reviewer_id == 11
556 | medical_reviewer_name == Puya Yazdi
556 | medical_reviewer_title == MD
556 | publish_date == 2020
556 | publish_date == 12
556 | publish_date == 17
556 | avg_rating == 5.0
556 | tags_id == 1032
556 | tags_name == Hair Follicle
556 | tags_id == 1033
556 | tags_name == Hair Growth Cycle
556 | tags_id == 1029
556 | tags_name == Hair Loss
556 | tags_id == 1028
556 | tags_name == Male-Pattern Baldness
556 | tags_id == 1017
556 | tags_name == PRDM1 Gene
556 | tags_id == 1049
556 | tags_name == Wnt
556 | tags_id == 1031
556 | tags_name == Wnt Signalling
556 | permissions_favorite == False
556 | permissions_rate == False
556 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">PRDM1 </span></em><span style="font-weight: 400;">codes for BLIMP-1, a protein that helps regulate hair growth by activating the Wnt signaling pathway. Variants of </span><em><span style="font-weight: 400;">PRDM1 </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by decreasing the production of BLIMP-1 and lowering Wnt signaling pathway activity. Lifestyle and supplement modifications may counteract the effects of these variants by stimulating the Wnt signaling pathway.</span></span></p> <h2 style="text-align: justify;"><strong><em>PRDM1</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/prdm1/"><em><span style="font-weight: 400;">PRDM1</span></em></a> <span style="font-weight: 400;">gene codes for B lymphocyte-induced maturation protein 1 (BLIMP-1), a protein reported to be essential for the growth and specialization of certain cell types, such as those found within hair follicles [</span><a href="https://www.ncbi.nlm.nih.gov/gene/639"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Hair follicles follow cycles that consist of three stages: cell proliferation, follicle regression, and rest. In line with its role in cell growth, BLIMP-1 levels have been reported to increase during cell proliferation and decrease during follicle regression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">BLIMP-1 may precede the activation of the </span><a href="https://selfdecode.com/blog/article/WNT10A-baldness-550/"><span style="font-weight: 400;">Wnt signaling pathway</span></a><span style="font-weight: 400;">, which has been suggested to help transition hair follicle cells from stages of rest to stages of growth [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11371349/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">PRDM1 </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. These variants may lower the production of BLIMP-1, resulting in hair cycle dysregulation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>PRDM1</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*6507181280911543*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>PRDM1 </em></strong><a href="https://selfdecode.com/snp/rs548234/"><strong>rs548234</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with male-pattern baldness</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>PRDM1 </em></strong><a href="https://selfdecode.com/snp/rs12214131/"><strong>rs12214131</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with male-pattern baldness</span></li> </ul> <p style="text-align: justify;">*5198449000575673*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*2104357242675059*</p> <h4 style="text-align: justify;"><strong>Low-Level Laser Therapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">) is the application of low-power lasers to the surface of the body. It seems to stimulate the production of nitric oxide and free radicals, both of which act as messenger molecules to trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In cell- and animal-based studies, LLLT was also shown to promote hair growth by stimulating the Wnt signaling pathway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28508243/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29468283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28944964/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29200764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The FDA approved this technique for male-pattern baldness in 2007. Meta-analyses of 11 different trials suggest that LLLT may improve hair growth and density, both alone and in combination with conventional treatments. However, they warned that larger studies with longer follow-up periods and independent sources of funding are required to confirm these results [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Low-level laser therapy may help manage male-pattern baldness by stimulating the Wnt signaling pathway.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Adenosine</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/adenosine-health-effects/"><span style="font-weight: 400;">Adenosine</span></a><span style="font-weight: 400;"> was found to lengthen the cell proliferation phase of hair follicles and subsequently promote hair growth, in part by stimulating a co-activator of the Wnt signaling pathway [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22020741/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Topical adenosine applied for 6 months increased the proportion of thick hair in two trials of men with male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25925959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26508659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In another trial of men with male-pattern baldness, a topical solution with 0.75% adenosine was as effective as minoxidil (a conventional medication) at recovering hair growth. Moreover, patients were more satisfied with adenosine because they perceived faster reduction of hair loss and growth of new hairs [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24183218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical adenosine may help manage male-pattern baldness by stimulating the Wnt signaling pathway.</span></p> <h4 style="text-align: justify;"><strong>Rice Bran</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Topical rice bran mineral extract was suggested to stimulate hair growth by activating the Wnt signaling pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727428/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a trial of men with male-pattern baldness, rice bran extract applied to the scalp for 16 weeks increased hair density and diameter [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26632177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This extract, especially its active components linoleic acid and gamma-oryzanol, induced hair growth and the development of hair follicles in mice [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24389480/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical rice bran may help manage male-pattern baldness by stimulating the Wnt signaling pathway.</span></p>
556 | content_snp_table_6507181280911543_key == 6507181280911543
556 | content_snp_table_6507181280911543_blur == True
556 | content_snp_table_6507181280911543_hidden == False
556 | content_learn_more_5198449000575673_key == 5198449000575673
556 | content_learn_more_5198449000575673_blur == True
556 | content_learn_more_5198449000575673_hidden == False
556 | content_learn_more_5198449000575673_text == Based on the variants we looked at, your PRDM1 gene makes you somewhat more likely to experience male-pattern baldness. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. Low-level laser therapy, topical adenosine, and topical rice bran may help. Keep scrolling to find out more.
556 | content_recommendation_2104357242675059_key == 2104357242675059
556 | content_recommendation_2104357242675059_blur == True
556 | content_recommendation_2104357242675059_hidden == False
rsIDs = rs548234,rs12214131
rsStatus = rs548234,,chr6,106120159,C,A,G,T,27,0,Normal
rsStatus = rs12214131,,chr6,105760046,G,A,,,25,10,HET
