558 | id == 558
558 | category_id == 30
558 | category_order == 27
558 | category_name == Hair Loss
558 | category_color == #C47AC0
558 | slug == TFAP2A-male-pattern-baldness
558 | title == Hair Pigmentation & Its Influence on Male-Pattern Baldness (TFAP2A)
558 | meta_description == TFAP2A alters hair pigmentation. Variants of TFAP2A may be associated with male-pattern baldness. Read more here.
558 | summary == <p style="text-align:justify"><strong><em>TFAP2A</em> codes for a protein that may alter hair pigmentation. How might variants of <em>TFAP2A</em>&nbsp;promote male-pattern baldness? Read more to find out.</strong></p>
558 | overall_score_text == Your Hair Loss Score (based on TFAP2A gene)
558 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TFAP2A-Male-pattern-baldness.jpg
558 | author_id == 14
558 | author_name == Shany Lahan
558 | author_title == MS (Neuroscience)
558 | author_order == 5
558 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
558 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
558 | reviewer == None
558 | medical_reviewer_id == 11
558 | medical_reviewer_name == Puya Yazdi
558 | medical_reviewer_title == MD
558 | publish_date == 2020
558 | publish_date == 12
558 | publish_date == 17
558 | avg_rating == 5.0
558 | tags_id == 1029
558 | tags_name == Hair Loss
558 | tags_id == 880
558 | tags_name == IRF4 Gene
558 | tags_id == 1028
558 | tags_name == Male-Pattern Baldness
558 | tags_id == 1054
558 | tags_name == Melanin
558 | tags_id == 1053
558 | tags_name == Pigmentation
558 | tags_id == 1052
558 | tags_name == TFAP2A Gene
558 | tags_id == 1055
558 | tags_name == Tyrosinase
558 | permissions_favorite == False
558 | permissions_rate == False
558 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">TFAP2A </span></em><span style="font-weight: 400;">codes for a protein that stimulates tyrosinase, a pigment-producing enzyme. Variants of </span><em><span style="font-weight: 400;">TFAP2A </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by decreasing tyrosinase production. Diet and supplement modifications may counteract the effects of these variants by increasing the activity of tyrosinase.</span></span></p> <h2 style="text-align: justify;"><strong><em>TFAP2A</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tfap2a/"><em><span style="font-weight: 400;">TFAP2A</span></em></a> <span style="font-weight: 400;">gene codes for transcription factor AP-2 alpha (TFAP2A), a protein involved in the production of </span><a href="https://selfdecode.com/blog/article/IRF4-baldness-542/"><span style="font-weight: 400;">IRF4</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25631878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Classically regarded as an immune protein, IRF4 has been reported to promote both pro- and anti-inflammatory immune responses [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003872/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, in the eyes, skin, and hair, IRF4 may alter pigmentation. IRF4 deficiency in hair follicles has been suggested to promote the transformation of dark and thick hair into light and thin hair, thereby contributing to hair loss [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344973/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25631878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This effect may be attributed to decreased tyrosinase activation. Tyrosinase is an enzyme that helps produce pigments such as melanin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">TFAP2A </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. These variants may decrease the production of TFAP2A, resulting in low levels of tyrosinase and hair loss [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>TFAP2A</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*6062859947598247*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>TFAP2A </em></strong><a href="https://selfdecode.com/snp/rs2876167/"><strong>rs2876167</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span><strong>&nbsp;</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;G&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>TFAP2A </em></strong><a href="https://selfdecode.com/snp/rs855250/"><strong>rs855250</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with male-pattern baldness</span></li> </ul> <p style="text-align: justify;"><strong><em>TFAP2A </em></strong><a href="https://selfdecode.com/snp/rs2149150/"><strong>rs2149150</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with male-pattern baldness</span></li> </ul> <p style="text-align: justify;">*4878434868810879*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*6178606381531313*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Eating Sufficient Proteins</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of 100 people with hair loss, most of the 34 subjects with male-pattern baldness had deficiencies of the essential amino acids </span><a href="https://www.selfhacked.com/blog/histidine/"><span style="font-weight: 400;">histidine</span></a><span style="font-weight: 400;">, </span><a href="https://www.selfhacked.com/blog/leucine-health-benefits-side-effects/"><span style="font-weight: 400;">leucine</span></a><span style="font-weight: 400;">, and isoleucine. Dietary sources of these amino acids include protein-rich foods such as meat, fish, dairy products, eggs, and legumes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596642/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Some protein-rich foods -- particularly beef -- also contain high amounts of copper. Copper may be essential for the activity of tyrosinase [</span><a href="https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855855/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The Recommended Dietary Allowance of protein is 0.8 g per kg of body weight, per day (for both men and women) [</span><a href="https://www.nap.edu/read/10490/chapter/12"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Eating sufficient amounts of protein may help manage male-pattern baldness by increasing tyrosinase activity.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Soy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">One protein-rich legume that may provide some extra benefits for individuals carrying risk variants of </span><em><span style="font-weight: 400;">TFAP2A </span></em><span style="font-weight: 400;">is soy. Soy contains genistein, a compound that was reported to increase the activity of tyrosinase in multiple studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15584372/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A Taiwanese study associated the regular consumption </span>(at least 1 to 3 days per week)<span> of soy drinks with a reduced incidence of male-pattern baldness [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875420/"><span>R</span></a><span>].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Soy may help prevent male-pattern baldness by increasing tyrosinase activity.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Red Clover</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Genistein is also found in </span><a href="https://selfhacked.com/blog/health-benefits-red-clover/"><span style="font-weight: 400;">red clover</span></a><span style="font-weight: 400;">, suggesting that red clover may similarly counter </span><em><span style="font-weight: 400;">TFAP2A </span></em><span style="font-weight: 400;">risk variants by stimulating tyrosinase [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15584372/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a trial of men with receding hair, a topical product with red clover applied for 4 months increased the amount of hair in the active growth phase by 13%, while reducing hair in the resting stage by 29% [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23449130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In mice, its active component formononetin promoted hair regrowth by preventing the death of hair follicles [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26756818/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Red clover may help manage male-pattern baldness by increasing tyrosinase activity.</span></p>
558 | content_snp_table_6062859947598247_key == 6062859947598247
558 | content_snp_table_6062859947598247_blur == True
558 | content_snp_table_6062859947598247_hidden == False
558 | content_learn_more_4878434868810879_key == 4878434868810879
558 | content_learn_more_4878434868810879_blur == True
558 | content_learn_more_4878434868810879_hidden == False
558 | content_learn_more_4878434868810879_text == Based on the variants we looked at, your TFAP2A gene is associated with somewhat higher odds of male-pattern baldness, relative to other variants. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. Eating sufficient proteins, consuming soy, and applying topical red clover may help. Keep scrolling to find out more.
558 | content_recommendation_6178606381531313_key == 6178606381531313
558 | content_recommendation_6178606381531313_blur == True
558 | content_recommendation_6178606381531313_hidden == False
rsIDs = rs2149150,rs2876167,rs855250
rsStatus = rs2149150,,chr6,9677162,C,A,,,25,0,Normal
rsStatus = rs2876167,,chr6,9481139,G,A,C,,4,22,HET
rsStatus = rs855250,,chr6,9608654,A,C,G,,27,0,Normal
