559 | id == 559
559 | category_id == 30
559 | category_order == 27
559 | category_name == Hair Loss
559 | category_color == #C47AC0
559 | slug == LRMDA-baldness
559 | title == A Hair Pigmentation Gene’s Role in Male-Pattern Baldness (LRMDA)
559 | meta_description == The LRMDA gene supports the development and function of melanocytes. How do these pigment cells affect hair loss?
559 | summary == <p><strong>The <em>LRMDA </em>gene supports the development and function of melanocytes. How do these pigment cells affect hair loss? Read on to find out.</strong></p>
559 | overall_score_text == Your Hair Loss Score (based on LRMDA)
559 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/LRMDA-Male-pattern-baldness.jpg
559 | author_id == 1
559 | author_name == Jasmine Foster
559 | author_title == BSc, BEd
559 | author_order == 36
559 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
559 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
559 | reviewer == None
559 | medical_reviewer_id == 11
559 | medical_reviewer_name == Puya Yazdi
559 | medical_reviewer_title == MD
559 | publish_date == 2020
559 | publish_date == 12
559 | publish_date == 18
559 | avg_rating == 5.0
559 | tags_id == 1032
559 | tags_name == Hair Follicle
559 | tags_id == 1033
559 | tags_name == Hair Growth Cycle
559 | tags_id == 1029
559 | tags_name == Hair Loss
559 | tags_id == 1056
559 | tags_name == LRMDA Gene
559 | tags_id == 1028
559 | tags_name == Male-Pattern Baldness
559 | tags_id == 1053
559 | tags_name == Pigmentation
559 | permissions_favorite == False
559 | permissions_rate == False
559 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> encodes leucine rich melanocyte differentiation associated protein. Variants of </span><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> may play a role in male-pattern baldness by disrupting the function of pigment-producing melanocytes. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by stimulating melanocyte activity.</span></p> <h2><strong><em>LRMDA</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/lrmda/"><em><span style="font-weight: 400;">LRMDA</span></em></a> <span style="font-weight: 400;">gene encodes leucine rich melanocyte differentiation associated protein. This protein is heavily involved in pigmentation of hair and skin. It helps the development of melanocytes, cells that produce melanin pigments and give skin and hair their color [</span><a href="https://www.ncbi.nlm.nih.gov/gene/83938"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mutations in </span><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> have been associated with oculocutaneous albinism (OCA), a condition in which a person does not produce melanin and thus has very pale, near-white skin, hair, and eyes [</span><a href="https://www.ncbi.nlm.nih.gov/gene/83938"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C0078918/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK519018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with oculocutaneous albinism are much more susceptible than the average person to sun damage and eventual skin cancer (melanoma). Doctors typically recommend that people with albinism cover as much of their skin as possible with long sleeves and pants when they go out in the sun; in the absence of a physical barrier, high SPF sunblock is recommended [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK519018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In addition to lightening the skin and hair, variants in </span><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> may cause hair to be thinner and less dense. Reduced LRMDA function results in lower numbers of melanocytes and less melanin production in the hair; poor melanocyte function is associated with reduced thickness and density of hair, especially in older people [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK519018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> gene supports the development and function of melanocytes, the cells responsible for giving skin, eyes, and hair their color. Poor melanocyte function may also thin out hair.</span></span></p> <h2><strong>Your</strong><strong><em> LRMDA </em></strong><strong>Results for Male-Pattern Baldness</strong></h2> <p>*1666370100918197*</p> <p><a href="https://selfdecode.com/gene/lrmda/"><strong>LRMDA</strong></a> <a href="https://selfdecode.com/snp/rs10762668/"><strong>rs10762668</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may disrupt the function of melanocytes, leading to the thinning of hair [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK519018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/lrmda/"><strong>LRMDA</strong></a> <a href="https://selfdecode.com/snp/rs117246174/"><strong>rs117246174</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher rates of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may disrupt the function of melanocytes, leading to the thinning of hair [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK519018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/lrmda/"><strong>LRMDA</strong></a> <a href="https://selfdecode.com/snp/rs1907350/"><strong>rs1907350</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower rates of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may disrupt the function of melanocytes, leading to the thinning of hair [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK519018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*2248938897145194*</p> <h2><strong>Recommendations for Improving Hair Growth</strong></h2> <p>*9676438451280851*</p> <h3><strong>LLLT</strong></h3> <p><span style="font-weight: 400;">Low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">) is the application of low-power lasers to the surface of the body. It appears to stimulate the activity of melanocytes, which may be reduced by some variants in </span><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;"> also seems to stimulate the production of NO and free radicals, both of which act as messenger molecules to trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The FDA approved this technique for male-pattern baldness in 2007. Meta-analyses of 11 different placebo-controlled trials suggest that LLLT may improve hair growth and density, both alone and in combination with conventional treatments. However, they warned that larger studies with longer follow-up periods and independent sources of funding are required to confirm these results [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">LLLT may promote hair growth by stimulating the activity of melanocytes, which may be suppressed by </span><em><span style="font-weight: 400;">LRMDA</span></em><span style="font-weight: 400;"> variants.</span></span></p> <h3><strong>Rosemary</strong></h3> <p><span style="font-weight: 400;">Rosmarinic acid, a compound derived from </span><a href="https://selfhacked.com/blog/rosemary-benefits/"><span style="font-weight: 400;">rosemary</span></a><span style="font-weight: 400;">, may help protect melanocytes from damage and mutation over time [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284349/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a placebo-controlled trial of 50 men with male-pattern baldness, topical </span><a href="https://selfhacked.com/blog/rosemary-benefits/"><span style="font-weight: 400;">rosemary</span></a><span style="font-weight: 400;"> oil applied for 6 months increased hair counts as effectively as minoxidil [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25842469/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In another placebo-controlled trial of 86 men, aromatherapy massage with rosemary and other essential oils (</span><a href="https://selfhacked.com/blog/lavender-health-benefits/"><span style="font-weight: 400;">lavender</span></a><span style="font-weight: 400;">, thyme, and cedarwood) improved hair density in 43% of those who received it [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9828867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Rosemary leaf extract promoted hair growth in mice with their backs shaved and hair regrowth in those treated with </span><a href="https://selfhacked.com/blog/testosterone-will-add/"><span style="font-weight: 400;">testosterone</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22517595/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Rosmarinic acid may help protect melanocytes from damage. Rosemary oils may improve hair density when applied to the scalp.</span></p>
559 | content_snp_table_1666370100918197_key == 1666370100918197
559 | content_snp_table_1666370100918197_blur == True
559 | content_snp_table_1666370100918197_hidden == False
559 | content_learn_more_2248938897145194_key == 2248938897145194
559 | content_learn_more_2248938897145194_blur == True
559 | content_learn_more_2248938897145194_hidden == False
559 | content_learn_more_2248938897145194_text == Based on the variants we looked at, your LRMDA gene is somewhat associated with reduced melanocyte activity. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. LLLT and topical rosemary oil may help. Keep scrolling to find out more.
559 | content_recommendation_9676438451280851_key == 9676438451280851
559 | content_recommendation_9676438451280851_blur == True
559 | content_recommendation_9676438451280851_hidden == False
rsIDs = rs1907350,rs10762668,rs117246174
rsStatus = rs1907350,LRMDA,chr10,76435054,A,G,T,,18,11,HET
rsStatus = rs10762668,LRMDA,chr10,75475944,C,T,,,31,1,HET
rsStatus = rs117246174,LRMDA,chr10,76411908,A,G,T,,56,2,HET
