561 | id == 561
561 | category_id == 30
561 | category_order == 27
561 | category_name == Hair Loss
561 | category_color == #C47AC0
561 | slug == FAM53B-hair-loss
561 | title == Can This Gene Stimulate Hair Growth? (FAM53B)
561 | meta_description == The FAM53B gene stimulates a crucial pathway for hair growth. Click to learn about its link with male-pattern baldness.
561 | summary == <p><strong>Did you know that genes can greatly affect your hair growth? Read this post to learn the link between <em>FAM53B</em> and male-pattern baldness, and get gene-based tips!</strong></p>
561 | overall_score_text == Your male-pattern baldness Score (based on FAM53B gene)
561 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FAM53B-Male-pattern-baldness.jpg
561 | author_id == 9
561 | author_name == Aleksa Ristic
561 | author_title == MS (Pharmacy)
561 | author_order == 45
561 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
561 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
561 | reviewer == None
561 | medical_reviewer_id == 11
561 | medical_reviewer_name == Puya Yazdi
561 | medical_reviewer_title == MD
561 | publish_date == 2020
561 | publish_date == 12
561 | publish_date == 22
561 | avg_rating == 5.0
561 | tags_id == 1059
561 | tags_name == Beta-catenin
561 | tags_id == 1057
561 | tags_name == FAM53B gene
561 | tags_id == 1058
561 | tags_name == Hair Growth
561 | tags_id == 1028
561 | tags_name == Male-Pattern Baldness
561 | tags_id == 1031
561 | tags_name == Wnt Signalling
561 | permissions_favorite == False
561 | permissions_rate == False
561 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The FAM53B gene stimulates the Wnt/beta-catenin pathway, which is crucial for hair growth.<br /><br /></strong><strong>Specific gene variants may reduce FAM53B activity. They&rsquo;ve been associated with relatively higher odds of male-pattern baldness.<br /><br /></strong><strong>This post reveals potential ways to boost hair growth by reducing the impact of your FAM53B variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of FAM53B in Hair Growth</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/fam53b/"><em><span style="font-weight: 400;">FAM53B</span></em></a><span style="font-weight: 400;"> gene enables the function of beta-catenin, a protein that stimulates hair follicles and promotes hair growth. This protein partakes in a so-called Wnt/beta-catenin pathway, which is often suppressed in people with male pattern baldness [</span><a href="https://www.ncbi.nlm.nih.gov/gene/9679"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25183871/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12015971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265840/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Substances that activate beta-catenin may boost hair growth by reducing the negative impact of excess </span><a href="https://selfhacked.com/blog/hidden-benefits-dht-increase-reduce/"><span style="font-weight: 400;">DHT</span></a><span style="font-weight: 400;">, which is the culprit behind male-pattern baldness. Researchers are developing new treatment options for this condition that target the Wnt/beta-catenin pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989660/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404278/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your FAM53B Results for Male-Pattern Baldness</strong></h2> <p>*5464122674570742*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs3781458/"><strong>rs3781458</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms14694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively lower odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely reduces FAM53B activity and suppresses beta-catenin</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs3781452/"><strong>rs3781452</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41467-018-07862-y"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively lower odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely reduces FAM53B activity and suppresses beta-catenin</span></li> </ul> <p>*4198523562077925*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Stimulate Hair Growth</strong></h2> <p>*3076377878898473*</p> <h3><strong>Scalp Massage</strong></h3> <p><span style="font-weight: 400;">Scalp massage (4 minutes daily for 6 months) improved hair thickness in one small study. In a larger survey, scalp massage improved self-perceived hair density in men [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scalp massage may promote hair growth by activating different growth factors and pathways, including the Wnt/beta-catenin pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25136212/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29194786/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Scalp massage may stimulate hair growth by targeting your gene variants.</span></p> <h3><strong>Low-Level Laser</strong></h3> <p><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">Low-level laser therapy</span></a><span style="font-weight: 400;"> (LLLT) is the application of low-power lasers to the surface of the body. It seems to stimulate the production of NO and free radicals, which trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In animal studies and test tubes, one type of laser treatment (CO2 laser) improved hair growth by boosting the Wnt/beta-catenin pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25945952/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705357/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The FDA approved LLLT for male-pattern baldness in 2007. According to meta-analyses of 11 clinical trials, it may improve hair growth and density, both alone and in combination with conventional treatments [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Low-level laser therapy (LLLT) may reduce the impact of your FAM53B variants and improve male-pattern baldness.&nbsp;</span></p> <h3><strong>Topical Adenosine</strong></h3> <p><span style="font-weight: 400;">The activation of adenosine receptors (A2aR) triggers the Wnt/beta-catenin pathway in the skin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28667836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Topical </span><a href="https://selfhacked.com/blog/adenosine-health-effects/"><span style="font-weight: 400;">adenosine</span></a><span style="font-weight: 400;"> applied for 6 months may increase hair thickness in men with male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25925959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26508659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one clinical trial, a topical solution with 0.75% adenosine was as effective as minoxidil at recovering hair growth. Study participants even perceived it as a better, faster-acting option [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24183218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical adenosine may promote hair growth by targeting your gene variants.</span></p>
561 | content_snp_table_5464122674570742_key == 5464122674570742
561 | content_snp_table_5464122674570742_blur == True
561 | content_snp_table_5464122674570742_hidden == False
561 | content_learn_more_4198523562077925_key == 4198523562077925
561 | content_learn_more_4198523562077925_blur == True
561 | content_learn_more_4198523562077925_hidden == False
561 | content_learn_more_4198523562077925_text == Based on the variants we looked at, your FAM53B gene is associated with relatively higher odds of male-pattern baldness. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. Topical adenosine application and scalp massage may promote hair growth by targeting your variant. Keep scrolling to find out more.
561 | content_recommendation_3076377878898473_key == 3076377878898473
561 | content_recommendation_3076377878898473_blur == True
561 | content_recommendation_3076377878898473_hidden == False
rsIDs = rs3781458,rs3781452
rsStatus = rs3781458,FAM53B,chr10,124655362,C,A,G,T,35,0,Normal
rsStatus = rs3781452,FAM53B,chr10,124666560,C,T,,,31,0,Normal
