567 | id == 567
567 | category_id == 30
567 | category_order == 27
567 | category_name == Hair Loss
567 | category_color == #C47AC0
567 | slug == SPATA8-male-baldness
567 | title == Is This Gene Preventing or Worsening Your Hair Loss? (SPATA8)
567 | meta_description == The SPATA8 gene suppresses a crucial pathway for hair growth. Learn about its link with male-pattern baldness.
567 | summary == <p style="text-align:justify"><strong>Are you ready to learn about another gene involved in hair growth? Read this post to learn how <em>SPATA8</em> variants correlate with male-pattern baldness&mdash;personalized tips included!</strong></p>
567 | overall_score_text == Your male-pattern baldness Score (based on SPATA8 gene)
567 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SUPT3H-CDC5L-SPATS1-Male-pattern-baldness.jpg
567 | author_id == 9
567 | author_name == Aleksa Ristic
567 | author_title == MS (Pharmacy)
567 | author_order == 45
567 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
567 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
567 | reviewer == None
567 | medical_reviewer_id == 11
567 | medical_reviewer_name == Puya Yazdi
567 | medical_reviewer_title == MD
567 | publish_date == 2020
567 | publish_date == 12
567 | publish_date == 22
567 | avg_rating == 5.0
567 | tags_id == 1045
567 | tags_name == Beta-Catenin
567 | tags_id == 1058
567 | tags_name == Hair Growth
567 | tags_id == 1028
567 | tags_name == Male-Pattern Baldness
567 | tags_id == 1072
567 | tags_name == SPATA8 gene
567 | tags_id == 1031
567 | tags_name == Wnt Signalling
567 | permissions_favorite == False
567 | permissions_rate == False
567 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The SPATA8 gene suppresses the Wnt/beta-catenin pathway, which is crucial for hair growth.<br /><br /></strong><strong>Specific gene variants may increase SPATA8 activity and thus inhibit the Wnt/beta-catenin pathway. They&rsquo;ve been associated with relatively higher odds of male-pattern baldness.<br /><br /></strong><strong>Read this post to discover potential ways to boost hair growth by targeting SPATA8 variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>How SPATA8 Impacts Hair Growth</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/spata8/"><em><span style="font-weight: 400;">SPATA8</span></em></a><em><span style="font-weight: 400;"> (SPATS1, DDIP)</span></em><span style="font-weight: 400;"> gene reduces the activity of a so-called </span><em><span style="font-weight: 400;">Wnt/beta-catenin pathway</span></em><span style="font-weight: 400;">, which stimulates hair follicles and promotes hair growth. This pathway is often suppressed in people with male pattern baldness [</span><a href="https://www.ncbi.nlm.nih.gov/gtr/genes/221409/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20603214/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12015971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265840/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Substances that activate beta-catenin may boost hair growth by reducing the negative impact of excess </span><a href="https://selfhacked.com/blog/hidden-benefits-dht-increase-reduce/"><span style="font-weight: 400;">DHT</span></a><span style="font-weight: 400;">, which is the culprit behind male-pattern baldness. Researchers are developing new treatment options for this condition that target the Wnt/beta-catenin pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989660/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404278/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your SPATA8 Results for Male-Pattern Baldness</strong></h2> <p>*3396709792532106*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs227808/"><strong>rs227808</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively lower odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely increases SPATA8 activity and suppresses the Wnt pathway.</span></li> </ul> <p><strong>Another Important SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs4714811/"><strong>rs4714811</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms14694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with relatively lower odds of male-pattern baldness</span></li> </ul> <p>*9309658410363533*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Boost Hair Growth</strong></h2> <p>*2663701745457447*</p> <h3><strong>Scalp Massage</strong></h3> <p><span style="font-weight: 400;">Scalp massage (4 minutes daily for 6 months) improved hair thickness in one small study. In a larger survey, scalp massage improved self-perceived hair density in men [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scalp massage may promote hair growth by activating different growth factors and pathways, including the Wnt/beta-catenin pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25136212/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29194786/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Scalp massage may lessen the impact of your gene and stimulate hair growth.</span></p> <h3><strong>LLLT</strong></h3> <p><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">Low-level laser therapy</span></a><span style="font-weight: 400;"> (LLLT) may stimulate hair growth through the Wnt/beta-catenin pathway [<a href="https://pubmed.ncbi.nlm.nih.gov/28508243/">R</a>]</span><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">In meta-analyses of 11 clinical trials, LLLT improved hair growth and density, both alone and in combination with conventional treatments. The FDA approved this therapy for male-pattern baldness in 2007&nbsp; [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Topical Adenosine</strong></h3> <p><span style="font-weight: 400;">The activation of adenosine receptors (A2aR) triggers the Wnt/beta-catenin pathway in the skin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28667836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Topical </span><a href="https://selfhacked.com/blog/adenosine-health-effects/"><span style="font-weight: 400;">adenosine</span></a><span style="font-weight: 400;"> applied for six months may increase hair thickness in men with male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25925959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26508659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one clinical trial, topical adenosine (0.75%) was as effective as minoxidil at recovering hair growth. Study participants even perceived it as a better, faster-acting option [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24183218/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical adenosine may promote hair growth by targeting your gene variants.</span></p>
567 | content_snp_table_3396709792532106_key == 3396709792532106
567 | content_snp_table_3396709792532106_blur == True
567 | content_snp_table_3396709792532106_hidden == False
567 | content_learn_more_9309658410363533_key == 9309658410363533
567 | content_learn_more_9309658410363533_blur == True
567 | content_learn_more_9309658410363533_hidden == False
567 | content_learn_more_9309658410363533_text == Based on the variants we looked at, your SPATA8 gene is associated with relatively higher odds of male-pattern baldness. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. Scalp massage may promote hair growth by targeting your variant. Keep scrolling to find out more.
567 | content_recommendation_2663701745457447_key == 2663701745457447
567 | content_recommendation_2663701745457447_blur == True
567 | content_recommendation_2663701745457447_hidden == False
rsIDs = rs4714811,rs227808
rsStatus = rs4714811,,chr6,44691849,C,A,G,T,31,1,HET
rsStatus = rs227808,,chr6,44699178,T,A,C,,37,0,Normal
