569 | id == 569
569 | category_id == 30
569 | category_order == 27
569 | category_name == Hair Loss
569 | category_color == #C47AC0
569 | slug == PAX1-male-pattern-baldness
569 | title == A Pathway Important for Hair Growth in Male-Pattern Baldness (PAX1)
569 | meta_description == PAX1 helps regulate hair growth. Variants of PAX1 are linked to male-pattern baldness. Read more here.
569 | summary == <p style="text-align:justify"><strong>The <em>PAX1 </em>gene may help regulate the hair cycle by modulating the activity of a pathway crucial for hair growth. How might variants of <em>PAX1</em> alter this function and promote the development of male-pattern baldness? Read more to find out.</strong></p>
569 | overall_score_text == Your Hair Loss Score (based on PAX1 gene)
569 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PAX1-Male-pattern-baldness.jpg
569 | author_id == 14
569 | author_name == Shany Lahan
569 | author_title == MS (Neuroscience)
569 | author_order == 5
569 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
569 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
569 | reviewer == None
569 | medical_reviewer_id == 11
569 | medical_reviewer_name == Puya Yazdi
569 | medical_reviewer_title == MD
569 | publish_date == 2020
569 | publish_date == 12
569 | publish_date == 23
569 | avg_rating == 5.0
569 | tags_id == 1076
569 | tags_name == EGFR
569 | tags_id == 1032
569 | tags_name == Hair Follicle
569 | tags_id == 1033
569 | tags_name == Hair Growth Cycle
569 | tags_id == 1029
569 | tags_name == Hair Loss
569 | tags_id == 1028
569 | tags_name == Male-Pattern Baldness
569 | tags_id == 1077
569 | tags_name == MAPK/ERK Pathway
569 | tags_id == 1075
569 | tags_name == PAX1 Gene
569 | permissions_favorite == False
569 | permissions_rate == False
569 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">PAX1 </span></em><span style="font-weight: 400;">codes for a protein that may regulate the hair growth cycle by modulating the activity of the MAPK/ERK pathway. Variants of </span><em><span style="font-weight: 400;">PAX1 </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by dysregulating PAX1 production and MAPK/ERK pathway activity. Lifestyle and diet modifications may counteract the effects of these variants by preventing overactivity of the MAPK/ERK pathway.</span></span></p> <h2 style="text-align: justify;"><strong><em>PAX1</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/pax1/"><em><span style="font-weight: 400;">PAX1</span></em></a> <span style="font-weight: 400;">gene codes for paired box 1 (PAX1), a protein that alters the activity of genes. PAX1 is essential for the development of the spinal column [</span><a href="https://www.ncbi.nlm.nih.gov/gene/5075"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Recent studies have linked PAX1 to hair loss. Although the mechanism behind this association is unclear, PAX1 has previously been reported to block the function of the epidermal growth factor receptor (EGFR) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591413/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">EGFR normally activates a pathway (MAPK/ERK) necessary for skin maintenance and the hair growth cycle, in which hair grows within a follicle, detaches from the follicle, and falls out. MAPK/ERK may specifically become activated during stages of hair growth and inactivated during stages of hair detachment [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK470321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, studies have demonstrated that both over- and underactivity of the MAPK/ERK pathway may perturb the hair growth cycle and promote progressive hair loss. This suggests that balanced MAPK/ERK pathway activity is essential for maintaining hair integrity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">PAX1 </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. It&rsquo;s possible that these variants may alter PAX1 production, resulting in dysregulated MAPK/ERK pathway activity and hair cycle perturbation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18849994/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/22032556"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002746"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>PAX1</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*2826057716502446*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>PAX1 </em></strong><a href="https://selfdecode.com/snp/rs2180439/"><strong>rs2180439</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18849994/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/22032556"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>PAX1 </em></strong><a href="https://selfdecode.com/snp/rs1160312/"><strong>rs1160312</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;G&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>PAX1 </em></strong><a href="https://selfdecode.com/snp/rs6047844/"><strong>rs6047844</strong></a><span style="font-weight: 400;"> [</span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002746"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;">*2155224017723223*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*5581312197679917*</p> <p style="text-align: justify;"><span style="font-weight: 400;">It&rsquo;s important to note that overactivity of the MAPK/ERK pathway may lead to the excessive growth and expansion of cells (i.e., cancer).</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The recommendations below may help avoid MAPK/ERK pathway overactivity, and may thus be advantageous to the management of male-pattern baldness and to the prevention of cancer. However, it&rsquo;s important to speak with your doctor before making any significant changes to your lifestyle, diet, or supplements -- especially if you may be at increased risk of cancer.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Cigarettes</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cigarettes are well known to excessively stimulate the MAPK/ERK pathway. Smoking cigarettes may therefore worsen hair cycle perturbation in individuals carrying risk variants of </span><em><span style="font-weight: 400;">PAX1 </span></em><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/22240207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556819/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Several studies have associated smoking with an approximately 2-fold increased risk of male-pattern baldness. Cigarette smoke may cause oxidative and inflammatory damage in the hair follicles, impair hair growth, and reduce female sex hormone levels. A study found that the combination of smoking with being overweight increased male-pattern baldness severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12673073/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28555720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18025364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32946667/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23629119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarettes may excessively stimulate the MAPK/ERK pathway. Avoiding cigarettes may help manage male-pattern baldness by preventing excessive MAPK/ERK pathway stimulation.</span></p> <h4 style="text-align: justify;"><strong>Maintain a Healthy Weight</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies have reported that unhealthy weight gain (linked to being overweight or obese) may excessively stimulate the MAPK/ERK pathway, suggesting that not maintaining a healthy weight may worsen the effects of </span><em><span style="font-weight: 400;">PAX1 </span></em><span style="font-weight: 400;">risk variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29079305/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32304665/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, being overweight or obese has been associated with increased severity of male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24184140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28555720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24746780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Being overweight or obese may excessively stimulate the MAPK/ERK pathway. Maintaining a healthy weight may help manage male-pattern baldness by preventing excessive MAPK/ERK pathway stimulation.</span></p>
569 | content_snp_table_2826057716502446_key == 2826057716502446
569 | content_snp_table_2826057716502446_blur == True
569 | content_snp_table_2826057716502446_hidden == False
569 | content_learn_more_2155224017723223_key == 2155224017723223
569 | content_learn_more_2155224017723223_blur == True
569 | content_learn_more_2155224017723223_hidden == False
569 | content_learn_more_2155224017723223_text == Based on the variants we looked at, your PAX1 gene is associated with somewhat higher odds of male-pattern baldness, relative to other variants. However, this doesn't necessarily reflect your overall risk of male-pattern baldness; it’s just one gene related to it. Avoiding cigarettes and maintaining a healthy weight may help. Keep scrolling to find out more.
569 | content_recommendation_5581312197679917_key == 5581312197679917
569 | content_recommendation_5581312197679917_blur == True
569 | content_recommendation_5581312197679917_hidden == False
rsIDs = rs2180439,rs6047844,rs1160312
rsStatus = rs2180439,,chr20,21872462,C,T,,,35,0,Normal
rsStatus = rs6047844,LINC01432,chr20,22056937,T,C,,,14,19,HET
rsStatus = rs1160312,LINC01432,chr20,22069865,A,C,G,T,30,0,Normal
