572 | id == 572
572 | category_id == 30
572 | category_order == 27
572 | category_name == Hair Loss
572 | category_color == #C47AC0
572 | slug == RUNX3-male-pattern-baldness
572 | title == The Involvement of a Complex Cellular Pathway in Male-Pattern Baldness (RUNX3)
572 | meta_description == RUNX3 promotes cell death. Variants of RUNX3 have been associated with male-pattern baldness. Read more here.
572 | summary == <p style="text-align:justify"><strong>RUNX3 may be involved in hair follicle cell death. How might variants of <em>RUNX3</em> promote male-pattern baldness? Read more to find out.</strong></p>
572 | overall_score_text == Your Hair Loss Score (based on RUNX3 gene)
572 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RUNX3-Male-pattern-baldness.jpg
572 | author_id == 14
572 | author_name == Shany Lahan
572 | author_title == MS (Neuroscience)
572 | author_order == 5
572 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
572 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
572 | reviewer == None
572 | medical_reviewer_id == 11
572 | medical_reviewer_name == Puya Yazdi
572 | medical_reviewer_title == MD
572 | publish_date == 2020
572 | publish_date == 12
572 | publish_date == 28
572 | avg_rating == 5.0
572 | tags_id == 216
572 | tags_name == Apoptosis
572 | tags_id == 768
572 | tags_name == Cell Death
572 | tags_id == 1032
572 | tags_name == Hair Follicle
572 | tags_id == 1033
572 | tags_name == Hair Growth Cycle
572 | tags_id == 1029
572 | tags_name == Hair Loss
572 | tags_id == 1028
572 | tags_name == Male-Pattern Baldness
572 | tags_id == 879
572 | tags_name == RUNX3 gene
572 | tags_id == 785
572 | tags_name == TGF-beta
572 | tags_id == 1084
572 | tags_name == TGF-beta Signaling Pathway
572 | permissions_favorite == False
572 | permissions_rate == False
572 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">RUNX3</span></em><span style="font-weight: 400;"> codes for an essential component of the TGF-beta signaling pathway, which may promote cell death in hair follicles. Variants of </span><em><span style="font-weight: 400;">RUNX3 </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by increasing production of RUNX3 and potentiating TGF-beta pathway activity. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing activity of the TGF-beta signaling pathway.</span></span></p> <h2 style="text-align: justify;"><strong><em>RUNX3</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/runx3/"><em><span style="font-weight: 400;">RUNX3</span></em></a> <span style="font-weight: 400;">gene codes for RUNX family transcription factor 3 (RUNX3), a protein that alters gene activity [</span><a href="https://www.ncbi.nlm.nih.gov/gene/864"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">RUNX3 has been shown to play an integral role in the </span><a href="https://selfhacked.com/blog/tgf/"><span style="font-weight: 400;">TGF-beta</span></a><span style="font-weight: 400;"> signaling pathway. This pathway may contribute to a wide array of cellular processes, including cell growth, cell specialization, and cell death [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12573434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133876/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, the TGF-beta pathway may help regulate the hair growth cycle, in which hair grows within follicles, hair follicles regress, and hair falls out [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133876/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In cells of the hair follicle, heightened activity of the TGF-beta pathway has been suggested to prematurely initiate hair follicle regression and in turn, shorten the hair growth cycle [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15194142/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">RUNX3 </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. These variants may increase RUNX3 activity, resulting in excessive cell death within hair follicles and consequent hair loss [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164265/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>RUNX3</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*7730825898131677*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>RUNX3 </em></strong><a href="https://selfdecode.com/snp/rs760805/"><strong>rs760805</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>RUNX3 </em></strong><a href="https://selfdecode.com/snp/rs742230/"><strong>rs742230</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;G&rsquo;</span></li> </ul> <p style="text-align: justify;"><strong><em>RUNX3 </em></strong><a href="https://selfdecode.com/snp/rs7517302/"><strong>rs7517302</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;">*7484282891084635*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*9492183509390097*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Cigarettes</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cigarette smoke is well-known to stimulate the TGF-beta pathway, suggesting that it may worsen the effects of </span><em><span style="font-weight: 400;">RUNX3 </span></em><span style="font-weight: 400;">risk variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30372878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26934369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286114/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31612392/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30090492/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Several studies have associated smoking with an approximately 2-fold increased risk of male-pattern baldness. Cigarette smoke may cause oxidative and inflammatory damage in the hair follicles, impair hair growth, and reduce female sex hormone levels. A study found that the combination of smoking with being overweight increased male-pattern baldness severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12673073/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28555720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18025364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32946667/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23629119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarettes may stimulate the TGF-beta pathway. Avoiding cigarettes may therefore help manage male-pattern baldness by preventing excessive TGF-beta signaling pathway stimulation.&nbsp;&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">Olive oil</span></a><span style="font-weight: 400;"> is the main source of fat in the Mediterranean diet. Olive oil has been found to lower TGF-beta pathway activity in multiple studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283896/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149435/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of men, the incidence of male-pattern baldness was reduced by over 50% in those consuming a Mediterranean diet rich in fresh vegetables (3 or more per week) and herbs (3 or more regularly) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29181579/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help manage male-pattern baldness by decreasing activity of the TGF-beta signaling pathway.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Topical Caffeine</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">Caffeine</span></a><span style="font-weight: 400;"> has been suggested to promote the growth of hair by reducing TGF-beta signaling pathway activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24836650/"><span style="font-weight: 400;">R</span></a>,<span style="font-weight: 400;">&nbsp;</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031145/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Topical lotions and shampoos with caffeine increased hair strength and thickness while decreasing hair loss in 4 trials of men with male-pattern baldness. The lotion enhanced the effectiveness of </span><a href="https://selfhacked.com/blog/topical-minoxidil-hair-loss/"><span style="font-weight: 400;">minoxidil</span></a><span style="font-weight: 400;"> (a conventional medication) in one of them [</span><a href="http://iscd.it/files/Use-of-a-Cosmetic-Caffeine-Lotion-in-the-Treatment-of-Male-Androgenetic-Alopecia.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.iscd.it/files/Use-of-a-Caffeine-Shampoo-for-the-Treatment-of-Male-Androgenetic-Alopecia.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://jmums.mazums.ac.ir/article-1-1689-en.html"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804833/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similarly, a shampoo with caffeine used for 6 months reduced hair loss and increased hair strength in women in one trial [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29512972/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Caffeine may help manage male-pattern baldness by decreasing activity of the TGF-beta signaling pathway.</span></p>
572 | content_snp_table_7730825898131677_key == 7730825898131677
572 | content_snp_table_7730825898131677_blur == True
572 | content_snp_table_7730825898131677_hidden == False
572 | content_learn_more_7484282891084635_key == 7484282891084635
572 | content_learn_more_7484282891084635_blur == True
572 | content_learn_more_7484282891084635_hidden == False
572 | content_learn_more_7484282891084635_text == Based on the variants we looked at, your RUNX3 gene is associated with somewhat lower odds of male-pattern baldness, relative to other variants. However, other genes and health factors may still contribute to your risk.
572 | content_recommendation_9492183509390097_key == 9492183509390097
572 | content_recommendation_9492183509390097_blur == True
572 | content_recommendation_9492183509390097_hidden == False
rsIDs = rs760805,rs742230,rs7517302
rsStatus = rs760805,RUNX3,chr1,24925432,A,T,,,15,15,HET
rsStatus = rs742230,RUNX3,chr1,24924933,G,A,,,16,14,HET
rsStatus = rs7517302,RUNX3,chr1,24927826,C,A,G,T,31,0,Normal
