575 | id == 575
575 | category_id == 30
575 | category_order == 27
575 | category_name == Hair Loss
575 | category_color == #C47AC0
575 | slug == RUNX1-male-pattern-baldness
575 | title == Cell Division Suppression & Male-Pattern Baldness (RUNX1)
575 | meta_description == RUNX1 promotes cell proliferation. Variants of RUNX1 are linked to male-pattern baldness. Read more here.
575 | summary == <p style="text-align:justify"><strong>RUNX1 helps promote cell proliferation by suppressing a cell division blocker. Read more to find out how variants of <em>RUNX1</em> may increase the odds of male-pattern baldness.&nbsp;</strong></p>
575 | overall_score_text == Your Hair Loss Score (based on RUNX1 gene)
575 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/RUNX1-Male-pattern-baldness----was-CLIC6.jpg
575 | author_id == 14
575 | author_name == Shany Lahan
575 | author_title == MS (Neuroscience)
575 | author_order == 5
575 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
575 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
575 | reviewer == None
575 | medical_reviewer_id == 11
575 | medical_reviewer_name == Puya Yazdi
575 | medical_reviewer_title == MD
575 | publish_date == 2020
575 | publish_date == 12
575 | publish_date == 29
575 | avg_rating == 5.0
575 | tags_id == 1087
575 | tags_name == Cell Cycle
575 | tags_id == 1086
575 | tags_name == Cell Division
575 | tags_id == 1032
575 | tags_name == Hair Follicle
575 | tags_id == 1033
575 | tags_name == Hair Growth Cycle
575 | tags_id == 1029
575 | tags_name == Hair Loss
575 | tags_id == 1028
575 | tags_name == Male-Pattern Baldness
575 | tags_id == 949
575 | tags_name == p21
575 | tags_id == 958
575 | tags_name == RUNX1 Gene
575 | permissions_favorite == False
575 | permissions_rate == False
575 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">RUNX1</span></em><span style="font-weight: 400;"> codes for a protein that suppresses the cell proliferation inhibitor p21. Variants of </span><em><span style="font-weight: 400;">RUNX1 </span></em><span style="font-weight: 400;">may play a role in male-pattern baldness by decreasing the production or activity of RUNX1, thereby increasing p21 activity. Lifestyle modifications may counteract the effects of these variants by decreasing p21 production.</span></span></p> <h2 style="text-align: justify;"><strong><em>RUNX1</em></strong><strong> and Male-Pattern Baldness</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://www.ncbi.nlm.nih.gov/gene/861"><em><span style="font-weight: 400;">RUNX1</span></em></a> <span style="font-weight: 400;">gene codes for RUNX family transcription factor 1 (RUNX1), a protein that alters the activity of genes [</span><a href="https://www.ncbi.nlm.nih.gov/gene/861"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Deletion of RUNX1 has been reported to perturb hair growth cycles and hair structure, suggesting that RUNX1 promotes hair follicle cell growth and expansion (proliferation) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17011173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, studies have shown that RUNX1 may suppress p21, a protein that blocks cell proliferation by regulating cell division [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788165/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">RUNX1 </span></em><span style="font-weight: 400;">have been associated with male-pattern baldness. These variants may lower the production or activity of RUNX1, resulting in increased p21 activity, reduced cell proliferation, and hair loss [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41467-018-07862-y"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>RUNX1</em></strong><strong> Results for Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*9492307699288982*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>RUNX1 </em></strong><a href="https://selfdecode.com/snp/rs68088846/"><strong>rs68088846</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41467-018-07862-y"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of male-pattern baldness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with male-pattern baldness</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>RUNX1 </em></strong><a href="https://selfdecode.com/snp/rs11701104/"><strong>rs11701104</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of male-pattern baldness, relative to &lsquo;T&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Lower odds of male-pattern baldness, relative to &lsquo;C&rsquo;</span></li> </ul> <p style="text-align: justify;">*4158216071453835*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Male-Pattern Baldness</strong></h2> <p style="text-align: justify;">*5450898752504532*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Low-Level Laser Therapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Low-level laser therapy (</span><a href="http://selfhacked.com/blog/my-review-of-lllt/"><span style="font-weight: 400;">LLLT</span></a><span style="font-weight: 400;">) is the application of low-power lasers to the surface of the body. It seems to stimulate the production of nitric oxide and free radicals, both of which act as messenger molecules to trigger physiological responses such as hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33111207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">LLLT may similarly promote the growth and expansion of cells by decreasing production of p21, suggesting that it may counter the negative effects of </span><em><span style="font-weight: 400;">RUNX1 </span></em><span style="font-weight: 400;">risk variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23804320/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11896194/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The FDA approved this technique for male-pattern baldness in 2007. Meta-analyses of 11 different trials suggest that LLLT may improve hair growth and density, both alone and in combination with conventional treatments. However, they warned that larger studies with longer follow-up periods and independent sources of funding are required to confirm these results [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29270707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29286826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30706177/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Low-level laser therapy may help manage male-pattern baldness by decreasing production of p21.</span></p> <h4 style="text-align: justify;"><strong>Maintaining a Healthy Weight</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In multiple studies, the amount of p21 was observed to be elevated in obese animals, suggesting that maintaining a healthy weight may help prevent the negative effects associated with </span><em><span style="font-weight: 400;">RUNX1 </span></em><span style="font-weight: 400;">risk variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26399684/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22194422/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Being overweight or obese has been associated with increased severity of male-pattern baldness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24184140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28555720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24746780/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Maintaining a healthy weight may help manage male-pattern baldness by preventing elevations in p21.</span></p>
575 | content_snp_table_9492307699288982_key == 9492307699288982
575 | content_snp_table_9492307699288982_blur == True
575 | content_snp_table_9492307699288982_hidden == False
575 | content_learn_more_4158216071453835_key == 4158216071453835
575 | content_learn_more_4158216071453835_blur == True
575 | content_learn_more_4158216071453835_hidden == False
575 | content_learn_more_4158216071453835_text == Based on the variants we looked at, your RUNX1 gene is associated with somewhat lower odds of male-pattern baldness, relative to other variants. However, other genes and health factors may still contribute to your risk.
575 | content_recommendation_5450898752504532_key == 5450898752504532
575 | content_recommendation_5450898752504532_blur == True
575 | content_recommendation_5450898752504532_hidden == False
rsIDs = rs11701104,rs68088846
rsStatus = rs11701104,RUNX1,chr21,34866220,C,G,T,,37,0,Normal
rsStatus = rs68088846,RUNX1,chr21,34835870,G,A,,,37,0,Normal
