582 | id == 582
582 | category_id == 30
582 | category_order == 27
582 | category_name == Hair Loss
582 | category_color == #C47AC0
582 | slug == ERBB3-alopecia-areata
582 | title == A Pathway Important for Hair Growth Cycles in Alopecia Areata (ERBB3)
582 | meta_description == ERBB3 helps regulate hair growth cycles. A variant of ERBB3 is linked to alopecia areata. Read more here.
582 | summary == <p style="text-align:justify"><strong>The <em>ERBB3</em> gene may help regulate hair growth cycles by modulating the activity of a pathway crucial for cell proliferation. How might variants of <em>ERBB3</em> promote the development of alopecia areata? Read more to find out.</strong><br />  &nbsp;</p>
582 | overall_score_text == Your Hair Loss Score (based on ERBB3 gene)
582 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ERBB3-Alopecia-areata.jpg
582 | author_id == 14
582 | author_name == Shany Lahan
582 | author_title == MS (Neuroscience)
582 | author_order == 5
582 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
582 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
582 | reviewer == None
582 | medical_reviewer_id == 11
582 | medical_reviewer_name == Puya Yazdi
582 | medical_reviewer_title == MD
582 | publish_date == 2020
582 | publish_date == 12
582 | publish_date == 31
582 | avg_rating == 5.0
582 | tags_id == 88
582 | tags_name == Alopecia Areata
582 | tags_id == 1093
582 | tags_name == ERBB3 Gene
582 | tags_id == 1032
582 | tags_name == Hair Follicle
582 | tags_id == 1033
582 | tags_name == Hair Growth Cycle
582 | tags_id == 1029
582 | tags_name == Hair Loss
582 | tags_id == 1077
582 | tags_name == MAPK/ERK Pathway
582 | permissions_favorite == False
582 | permissions_rate == False
582 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">ERBB3 </span></em><span style="font-weight: 400;">codes for a protein that may regulate the hair growth cycle by modulating the activity of the MAPK/ERK pathway. A variant of </span><em><span style="font-weight: 400;">ERBB3 </span></em><span style="font-weight: 400;">may play a role in alopecia areata by dysregulating ERBB3 production and MAPK/ERK pathway activity. Lifestyle modifications may counteract the effects of this variant by preventing overactivity of the MAPK/ERK pathway.</span></span></p> <h2 style="text-align: justify;"><strong><em>ERBB3</em></strong><strong> and Alopecia Areata</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/erbb3/"><em><span style="font-weight: 400;">ERBB3</span></em></a> <span style="font-weight: 400;">gene codes for erb-b2 receptor tyrosine kinase 3 (ERBB3), a receptor that regulates proliferation, survival, and metabolic pathways within cells [</span><a href="https://www.ncbi.nlm.nih.gov/gene/2065"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964743/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">One of the pathways regulated by ERBB3 is MAPK/ERK. MAPK/ERK is essential for skin maintenance and the hair growth cycle, in which hair grows within a follicle, detaches from the follicle, and falls out. This pathway may specifically become activated during stages of hair growth and inactivated during stages of hair detachment [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK470321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, studies have demonstrated that both over- and underactivity of the MAPK/ERK pathway may perturb the hair growth cycle. It&rsquo;s possible that this perturbation may contribute to the autoimmune (self-targeting) disorder </span><em><span style="font-weight: 400;">alopecia areata</span></em><span style="font-weight: 400;"> (spot baldness), in which T cells disrupt active hair growth stages of the hair growth cycle [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28992198/"><span style="font-weight: 400;">R</span></a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">ERBB3 </span></em><span style="font-weight: 400;">has been associated with </span><span style="font-weight: 400;">alopecia areata</span><span style="font-weight: 400;">. This variant may alter ERBB3 production, resulting in dysregulated MAPK/ERK pathway activity and hair cycle perturbation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451186/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>ERBB3</em></strong><strong> Results for Alopecia Areata</strong></h2> <p style="text-align: justify;">*9414846474547596*</p> <p style="text-align: justify;"><strong>Primary SNP:&nbsp;&nbsp;</strong></p> <p style="text-align: justify;"><strong><em>ERBB3 </em></strong><a href="https://selfdecode.com/snp/rs2292239/"><strong>rs2292239</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451186/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Higher odds of alopecia areata, relative to &lsquo;G&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Lower odds of alopecia areata, relative to &lsquo;T&rsquo;</span></li> </ul> <p style="text-align: justify;">*6257460971356885*</p> <h2 style="text-align: left;"><strong>Recommendations for Managing Alopecia Areata</strong></h2> <p style="text-align: justify;">*8997171139713425*</p> <p style="text-align: justify;"><span style="font-weight: 400;">It&rsquo;s important to note that overactivity of the MAPK/ERK pathway may lead to the excessive growth and expansion of cells (i.e., cancer).</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The recommendations below may help avoid MAPK/ERK pathway overactivity, and may thus be advantageous to the management of alopecia areata and to the prevention of cancer. However, it&rsquo;s important to speak with your doctor before making any significant changes to your lifestyle, diet, or supplements -- especially if you may be at increased risk of cancer.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Stress Management</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Stress may stimulate the MAPK/ERK pathway. In one study, stress early in adolescence was suggested to promote pro-inflammatory immune profiles, in part by enhancing MAPK/ERK activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25373870/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28664925/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although it has no direct effect on male-pattern baldness, stress is a well-known trigger of other types of hair loss such as diffuse hair loss (</span><em><span style="font-weight: 400;">telogen</span></em> <em><span style="font-weight: 400;">effluvium</span></em><span style="font-weight: 400;">), spot baldness (</span><em><span style="font-weight: 400;">alopecia</span></em> <em><span style="font-weight: 400;">areata</span></em><span style="font-weight: 400;">), and hair pulling disorder (</span><em><span style="font-weight: 400;">trichotillomania</span></em><span style="font-weight: 400;">). In turn, hair loss can be a source of stress and ultimately worsen the severity of these conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9676515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19487557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29212074/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15117365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30152568/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16897695/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">We&zwnj; &zwnj;recommend&zwnj; &zwnj;addressing&zwnj; &zwnj;sources&zwnj; &zwnj;of&zwnj; &zwnj;stress&zwnj; &zwnj;in&zwnj; &zwnj;your&zwnj; &zwnj;life,&zwnj; &zwnj;either&zwnj; &zwnj;by&zwnj; &zwnj;taking&zwnj; &zwnj;up&zwnj; &zwnj;a&zwnj; &zwnj;stress-busting&zwnj; hobby&zwnj; &zwnj;(such&zwnj; &zwnj;as&zwnj; &zwnj;&zwnj;</span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span><span style="font-weight: 400;">&zwnj;&zwnj;</span></a><span style="font-weight: 400;"> &zwnj;or&zwnj; &zwnj;&zwnj;</span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span><span style="font-weight: 400;">&zwnj;</span></a><span style="font-weight: 400;">)&zwnj; &zwnj;or&zwnj; &zwnj;seeking&zwnj; &zwnj;professional&zwnj; &zwnj;help.&zwnj;&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Stress may excessively stimulate the MAPK/ERK pathway. Stress management (for example, by practicing yoga or meditation) may help manage alopecia areata by preventing excessive MAPK/ERK pathway stimulation.</span></p> <h4 style="text-align: justify;"><strong>Giving Up Smoking</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cigarettes are well known to excessively stimulate the MAPK/ERK pathway. Smoking cigarettes may therefore worsen hair cycle perturbation in individuals carrying risk variants of </span><em><span style="font-weight: 400;">ERBB3 </span></em><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/22240207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556819/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a large study in which 154 individuals developed alopecia areata, smoking was associated with an approximately 2-fold increased incidence of this condition. Cigarette smoke may cause oxidative and inflammatory damage in the hair follicles, and impair hair growth [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32761499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12673073/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cigarettes may excessively stimulate the MAPK/ERK pathway. Avoiding cigarettes may help manage alopecia areata by preventing excessive MAPK/ERK pathway stimulation.</span></p>
582 | content_snp_table_9414846474547596_key == 9414846474547596
582 | content_snp_table_9414846474547596_blur == True
582 | content_snp_table_9414846474547596_hidden == False
582 | content_learn_more_6257460971356885_key == 6257460971356885
582 | content_learn_more_6257460971356885_blur == True
582 | content_learn_more_6257460971356885_hidden == False
582 | content_learn_more_6257460971356885_text == Based on the variants we looked at, your ERBB3 gene is associated with somewhat lower odds of alopecia areata, relative to other variants. However, other genes and health factors may still contribute to your risk.
582 | content_recommendation_8997171139713425_key == 8997171139713425
582 | content_recommendation_8997171139713425_blur == True
582 | content_recommendation_8997171139713425_hidden == False
rsIDs = rs2292239
rsStatus = rs2292239,ERBB3,chr12,56088396,T,C,G,,45,0,Normal
