589 | id == 589
589 | category_id == 63
589 | category_order == 28
589 | category_name == Skin Health
589 | category_color == #C47AC0
589 | slug == ATM-melanoma
589 | title == DNA Repair & Cell Division Control in Melanoma (ATM)
589 | meta_description == ATM helps with DNA repair and controls cell division. Variants of ATM are linked to melanoma. Read more here.
589 | summary == <p style="text-align:justify"><strong><em>ATM</em> helps with DNA repair and controls cell division. How might variants of <em>ATM</em> increase the odds of melanoma? Read more to find out.</strong></p>
589 | overall_score_text == Your Melanoma Score (based on ATM gene)
589 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ATM-NPAT-Melanoma.jpg
589 | author_id == 14
589 | author_name == Shany Lahan
589 | author_title == MS (Neuroscience)
589 | author_order == 5
589 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
589 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
589 | reviewer == None
589 | medical_reviewer_id == 11
589 | medical_reviewer_name == Puya Yazdi
589 | medical_reviewer_title == MD
589 | publish_date == 2021
589 | publish_date == 1
589 | publish_date == 6
589 | avg_rating == 5.0
589 | tags_id == 1107
589 | tags_name == ATM Gene
589 | tags_id == 164
589 | tags_name == Cancer
589 | tags_id == 1087
589 | tags_name == Cell Cycle
589 | tags_id == 1086
589 | tags_name == Cell Division
589 | tags_id == 1108
589 | tags_name == CHK2
589 | tags_id == 750
589 | tags_name == DNA Damage
589 | tags_id == 40
589 | tags_name == DNA Repair
589 | tags_id == 1100
589 | tags_name == Melanoma
589 | tags_id == 1101
589 | tags_name == Skin Cancer
589 | permissions_favorite == False
589 | permissions_rate == False
589 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">ATM </span></em><span style="font-weight: 400;">encodes a protein necessary for DNA repair and cell division control. Variants of </span><em><span style="font-weight: 400;">ATM </span></em><span style="font-weight: 400;">may play a role in melanoma by lowering the production of ATM. Diet and supplement modifications may counteract the effects of these variants by increasing ATM production or activity.</span></span></p> <h2 style="text-align: justify;"><strong><em>ATM</em></strong><strong> and Melanoma</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/atm/"><em><span style="font-weight: 400;">ATM</span></em></a> <span style="font-weight: 400;">gene codes for ATM serine/threonine kinase (ATM), an enzyme that adds phosphate molecules to proteins in order to alter their function [</span><a href="https://www.ncbi.nlm.nih.gov/gene/472"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://medlineplus.gov/genetics/gene/atm/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">ATM has been shown to sense damaged DNA strands and subsequently activate enzymes that promote their repair. ATM may also be able to regulate the division rates of cells by activating CHK2, an enzyme involved in cell cycle control [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9115420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://medlineplus.gov/genetics/gene/atm/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21034966/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a type of skin cancer called melanoma, DNA-damaged cells divide and proliferate uncontrollably [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">ATM </span></em><span style="font-weight: 400;">has been associated with melanoma. This variant may lower ATM activity, resulting in cumulative DNA damage and uncontrolled cell proliferation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/21983787"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>ATM</em></strong><strong> Results for Melanoma</strong></h2> <p style="text-align: justify;">*8221538043307643*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>ATM </em></strong><a href="https://selfdecode.com/snp/rs1801516/"><strong>rs1801516</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/21983787"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of melanoma, relative to &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Lower odds of melanoma, relative to &lsquo;G&rsquo;</span></li> </ul> <p style="text-align: justify;">*4087418563378686*</p> <h2 style="text-align: left;"><strong>Recommendations for Preventing Melanoma</strong></h2> <p style="text-align: justify;">*3643844082490226*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, fish, vegetables, legumes, and fresh fruit.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Extra-virgin olive oil was observed to increase the production and activity of ATM in a study of cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17999988/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Adherence to the Mediterranean diet has been associated with a reduction in the risk of melanoma by approximately 30% in multiple studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31380561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18621803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26212104/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, high intake of citrus fruits (a common ingredient of the Mediterranean diet) is linked to an </span><em><span style="font-weight: 400;">increased </span></em><span style="font-weight: 400;">risk of melanoma. The high psoralen content of these fruits may make the skin more sensitive to UV radiation, which can damage DNA [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979231/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31335211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32791010/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32710289/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help prevent melanoma by increasing the production and activity of ATM.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Vitamin D</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D may turn on the </span><em><span style="font-weight: 400;">ATM </span></em><span style="font-weight: 400;">gene, thereby increasing ATM production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16002434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Research has found no association between blood </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> levels and risk of melanoma, but deficiency in this vitamin predicted a poorer outcome in 2 studies of people with melanoma. In a large trial of women, supplementation with vitamin D and </span><a href="https://selfhacked.com/blog/calcium-101/"><span style="font-weight: 400;">calcium</span></a><span style="font-weight: 400;"> reduced the incidence of melanoma in those with a history of other skin cancer types [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695831/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22880705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773226/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157967/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin D may help prevent melanoma by increasing the production of ATM.&nbsp;</span></p>
589 | content_snp_table_8221538043307643_key == 8221538043307643
589 | content_snp_table_8221538043307643_blur == True
589 | content_snp_table_8221538043307643_hidden == False
589 | content_learn_more_4087418563378686_key == 4087418563378686
589 | content_learn_more_4087418563378686_blur == True
589 | content_learn_more_4087418563378686_hidden == False
589 | content_learn_more_4087418563378686_text == Based on the variants we looked at, your ATM gene is associated with somewhat lower odds of melanoma, relative to other variants. However, other genes and health factors may still contribute to your risk.
589 | content_recommendation_3643844082490226_key == 3643844082490226
589 | content_recommendation_3643844082490226_blur == True
589 | content_recommendation_3643844082490226_hidden == False
rsIDs = rs1801516
rsStatus = rs1801516,ATM,chr11,108304735,G,A,,,28,0,Normal
