590 | id == 590
590 | category_id == 63
590 | category_order == 28
590 | category_name == Skin Health
590 | category_color == #C47AC0
590 | slug == CDK10-melanoma
590 | title == Disruptions of the Cell Cycle in Melanoma Development (CDK10)
590 | meta_description == The CDK10 gene encodes a protein that helps regulate the growth and reproduction of cells. What is its role in melanoma?
590 | summary == <p><strong>The <em>CDK10 </em>gene encodes a protein that helps regulate the growth and reproduction of cells. What is its role in melanoma? Read on to find out.</strong></p>
590 | overall_score_text == Your Melanoma Score (based on CDK10)
590 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CDK10-Melanoma.jpg
590 | author_id == 1
590 | author_name == Jasmine Foster
590 | author_title == BSc, BEd
590 | author_order == 36
590 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
590 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
590 | reviewer == None
590 | medical_reviewer_id == 1
590 | medical_reviewer_name == Jasmine Foster
590 | medical_reviewer_title == BSc, BEd
590 | publish_date == 2021
590 | publish_date == 1
590 | publish_date == 7
590 | avg_rating == 5.0
590 | tags_id == 164
590 | tags_name == Cancer
590 | tags_id == 1109
590 | tags_name == CDK10 Gene
590 | tags_id == 1087
590 | tags_name == Cell Cycle
590 | tags_id == 1086
590 | tags_name == Cell Division
590 | tags_id == 1110
590 | tags_name == ETS2
590 | tags_id == 378
590 | tags_name == Growth
590 | tags_id == 1100
590 | tags_name == Melanoma
590 | tags_id == 1101
590 | tags_name == Skin Cancer
590 | permissions_favorite == False
590 | permissions_rate == False
590 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> encodes cyclin dependent kinase 10. Variants of </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> may play a role in melanoma by disrupting the cell cycle. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by stabilizing the cell cycle and preventing uncontrolled growth.</span></p> <h2><strong><em>CDK10</em></strong><strong> and Melanoma</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/cdk10/"><em><span style="font-weight: 400;">CDK10</span></em></a><span style="font-weight: 400;"> gene encodes a protein called cyclin dependent kinase 10. This protein plays a role in the growth and reproduction of cells at a very specific point during the cell&rsquo;s reproductive cycle [</span><a href="https://www.ncbi.nlm.nih.gov/gene/8558"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mutations in </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> have been linked to STAR syndrome, a very rare condition that causes deformities in the fingers, toes, skull, anus, genitals, and kidneys; other organs and systems may also be affected. Variants associated with STAR syndrome appear to decrease the production of the CDK10 protein [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://rarediseases.info.nih.gov/diseases/10295/star-syndrome"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Oddly, variation in the </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> gene is also believed to affect hair and skin color as well as body weight [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=8558"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31427789/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many cancers develop when cells lose the ability to regulate their own growth and reproduction. Because of CDK10&rsquo;s role in the cell cycle, it has been extensively studied for its relationship to cancer in general and melanoma in particular [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">CDK10 interacts with ETS2, another protein that has been strongly associated with melanoma. Through ETS2, variants in </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> may allow cells to reproduce without the usual control mechanisms of the cell cycle. Cells that reproduce uncontrollably form tumors, which can then become cancerous [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369473/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> gene encodes a protein that helps regulate the growth and reproduction of cells. Some variants of this gene may interact with ETS2 to promote unregulated cell growth and melanoma.</span></span></p> <h2><strong>Your </strong><strong><em>CDK10</em></strong><strong> Results for Melanoma</strong></h2> <p>*2738041975318588*</p> <p><a href="https://selfdecode.com/gene/cdk10/"><strong>CDK10</strong></a> <a href="https://selfdecode.com/snp/rs35063026/"><strong>rs35063026</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower rates of melanoma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher rates of melanoma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may interact with ETS2 to promote unregulated cell growth and melanoma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369473/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfdecode.com/gene/cdk10/"><strong>CDK10</strong></a> <a href="https://selfdecode.com/snp/rs258322/"><strong>rs258322</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/21983787"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/19578364"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower rates of melanoma&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of melanoma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may interact with ETS2 to promote unregulated cell growth and melanoma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564841/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369473/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*2245354420035454*</p> <h2><strong>Recommendations for Preventing Melanoma</strong></h2> <p>*2150028733859663*</p> <h3><strong>Avoid UV Exposure</strong></h3> <p><span style="font-weight: 400;">Ultraviolet light exposure can cause disruptions to the regulation of the cell cycle by damaging DNA. This may be especially dangerous for people with detrimental </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> variants who may already have disrupted cell cycles [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17355234/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Excessive, unprotected exposure to UV radiation is by far the main risk factor for the development of melanoma. UV from both the sun and artificial sources (tanning beds and sun lamps) damages the DNA of pigment-producing cells (melanocytes), potentially causing mutations that turn these cells into melanomas [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25398793/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29936410/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24629998/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with low levels of the protective pigment melanin, who typically have fair skin, blond or red hair, and light-colored eyes, are at higher risk of melanoma than those with dark skin [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31002590"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Alternatively, every single mole has a small probability of turning into cancer. Having a high number of moles, especially if they are large or have atypical features, also increases the risk of this skin cancer type [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2545764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26934430"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Reducing exposure to UV by limiting sun exposure (especially during the middle of the day), wearing protective clothing and sunscreen, and being aware of skin-sensitizing medications can greatly reduce the risk of melanoma.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exposure to UV light can cause DNA damage and disrupt the cell cycle. UV radiation is also a major risk factor for melanoma.</span></p> <h3><strong>B Vitamins</strong></h3> <p><span style="font-weight: 400;">Vitamins </span><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">B9</span></a><span style="font-weight: 400;"> (folate) and </span><a href="https://selfhacked.com/blog/vitamin-b12/"><span style="font-weight: 400;">B12</span></a><span style="font-weight: 400;"> (cobalamin) help regulate the cell cycle, and deficiencies in these nutrients may cause disruptions to the normal growth and reproduction of cells. People with detrimental </span><em><span style="font-weight: 400;">CDK10</span></em><span style="font-weight: 400;"> variants, who may already be prone to disruptions in the cell cycle, should be sure to get enough B9 and B12 either through their diets or supplementation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15189127/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplementation with a combination of </span><a href="http://selfhacked.com/blog/vitamin-b6/"><span style="font-weight: 400;">vitamin B6</span></a><span style="font-weight: 400;"> (pyridoxine), </span><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">folate</span></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/vitamin-b12/"><span style="font-weight: 400;">B12</span></a><span style="font-weight: 400;"> was associated with a reduced incidence of melanoma in 3 studies of over 119,000 people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22474057/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16531613/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593624/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The National Institutes of Health recommends an intake of at least 400 mcg of folate and 2.4 mcg of vitamin B12 per day. Liver and green vegetables are the richest dietary sources of folate; shellfish, fish, and liver are the richest dietary sources of B12 [</span><a href="https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Deficiencies in vitamins B9 and B12 may disrupt the cell cycle, and supplementing with these vitamins has been linked to a reduced incidence of melanoma.</span></p>
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590 | content_learn_more_2245354420035454_key == 2245354420035454
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590 | content_learn_more_2245354420035454_text == Based on the variants we looked at, your CDK10 gene is somewhat associated with disruptions to the cell cycle. However, this doesn't necessarily reflect your overall risk of melanoma; it’s just one gene related to it. Avoiding UV exposure and increasing B vitamin intake may help. Keep scrolling to find out more.
590 | content_recommendation_2150028733859663_key == 2150028733859663
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rsIDs = rs35063026,rs258322
rsStatus = rs35063026,SPATA33,chr16,89669749,C,T,,,32,0,Normal
rsStatus = rs258322,CDK10,chr16,89689495,A,G,T,,7,25,HET
