593 | id == 593
593 | category_id == 63
593 | category_order == 28
593 | category_name == Skin Health
593 | category_color == #C47AC0
593 | slug == CCND1-melanoma
593 | title == A Gene That Promotes Cell Division & Its Role in Melanoma (CCND1)
593 | meta_description == CCND1 promotes cell division. A variant of CCND1 has been linked to melanoma. Read more here.
593 | summary == <p style="text-align:justify"><strong>The <em>CCND1</em> gene may promote cell division. How might a variant of <em>CCND1</em> exploit this function to promote the development of a type of skin cancer called melanoma? Read more to find out.</strong></p>
593 | overall_score_text == Your Melanoma Score (based on CCND1 gene)
593 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CCND1-Melanoma.jpg
593 | author_id == 14
593 | author_name == Shany Lahan
593 | author_title == MS (Neuroscience)
593 | author_order == 5
593 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
593 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
593 | reviewer == None
593 | medical_reviewer_id == 11
593 | medical_reviewer_name == Puya Yazdi
593 | medical_reviewer_title == MD
593 | publish_date == 2021
593 | publish_date == 1
593 | publish_date == 9
593 | avg_rating == 5.0
593 | tags_id == 1115
593 | tags_name == CCND1 Gene
593 | tags_id == 1087
593 | tags_name == Cell Cycle
593 | tags_id == 1086
593 | tags_name == Cell Division
593 | tags_id == 1116
593 | tags_name == Cyclin D1
593 | permissions_favorite == False
593 | permissions_rate == False
593 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">CCND1</span></em><span style="font-weight: 400;"> codes for cyclin D1, a protein that promotes cell division. A variant of </span><em><span style="font-weight: 400;">CCND1 </span></em><span style="font-weight: 400;">may play a role in melanoma by elevating cyclin D1 levels and promoting uncontrollable cell proliferation. Lifestyle, diet, and supplement modifications may counteract the effects of this variant by lowering or limiting the production of cyclin D1.</span></span></p> <h2 style="text-align: justify;"><strong><em>CCND1</em></strong><strong> and Melanoma</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/ccnd1/"><em><span style="font-weight: 400;">CCND1</span></em></a> <span style="font-weight: 400;">gene codes for cyclin D1, a protein that promotes cell survival, growth, and proliferation by stimulating cell division [</span><a href="https://www.ncbi.nlm.nih.gov/gene/595"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">While the process of cell division is tightly controlled under normal conditions, cancer cells are able to bypass this regulation in order to divide uncontrollably [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, multiple studies have shown that levels of cyclin D1 are significantly elevated in melanoma and other forms of cancer [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32147907/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Unsurprisingly, a variant of </span><em><span style="font-weight: 400;">CCND1 </span></em><span style="font-weight: 400;">has been associated with melanoma. This variant may increase the production of cyclin D1, resulting in excessive cell division and melanoma progression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26237428"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>CCND1</em></strong><strong> Results for Melanoma</strong></h2> <p style="text-align: justify;">*7189465491323932*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>CCND1 </em></strong><a href="https://selfdecode.com/snp/rs498136/"><strong>rs498136</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/26237428"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher odds of melanoma, relative to &lsquo;C&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower odds of melanoma, relative to &lsquo;A&rsquo;</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">*5383937426324381*</span></p> <h2 style="text-align: left;"><strong>Recommendations for Preventing Melanoma</strong></h2> <p style="text-align: justify;">*7967366276533201*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Reducing Alcohol Intake</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Long-term alcohol consumption may promote cell proliferation, in part by increasing the production of cyclin D1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928606/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Meta-analyses of 20 studies have associated moderate alcohol consumption with a slight increase (7-18%) in the overall incidence of melanoma. A study of 1374 cases found that alcohol specifically increased the risk of melanoma in sites with low exposure to </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> (such as the trunk) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24495200/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29327230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137801/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Reducing alcohol intake may help prevent melanoma by limiting the production of cyclin D1.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet is rich in </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">, fish, vegetables, legumes, and fresh fruit. One traditional food eaten as part of the Mediterranean diet is gazpacho, a cold soup made from vegetables and tomatoes (which are actually fruits!).</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Gazpacho was found to lower the production of cyclin D1. This effect was mainly attributed to the antiproliferative effect of tomatoes and their pigment, </span><a href="https://selfhacked.com/blog/lycopene/"><span style="font-weight: 400;">lycopene</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31108768/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Adherence to the Mediterranean diet has been associated with a reduction in the risk of melanoma by approximately 30% in multiple studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31380561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18621803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26212104/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, high intake of citrus fruits (a common ingredient of the Mediterranean diet) is linked to an </span><em><span style="font-weight: 400;">increased </span></em><span style="font-weight: 400;">risk of melanoma. The high psoralen content of these fruits may make the skin more sensitive to UV radiation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979231/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31335211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32791010/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32710289/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may help prevent melanoma by lowering the production of cyclin D1.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Vitamin D</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">A number of studies focused on various cancer types have found that <a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/" target="_blank" rel="noopener">vitamin D</a> may suppress cyclin D1 production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338660/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Research has found no association between blood </span><span style="font-weight: 400;">vitamin D</span><span style="font-weight: 400;"> levels and risk of melanoma, but deficiency in this vitamin predicted a poorer outcome in 2 studies of over 1000 people with melanoma. In a large trial of women, supplementation with vitamin D and </span><a href="https://selfhacked.com/blog/calcium-101/"><span style="font-weight: 400;">calcium</span></a><span style="font-weight: 400;"> reduced the incidence of melanoma in those with a history of other skin cancer types [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695831/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22880705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773226/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157967/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Vitamin D may help prevent melanoma by suppressing cyclin D1.</span></p>
593 | content_snp_table_7189465491323932_key == 7189465491323932
593 | content_snp_table_7189465491323932_blur == True
593 | content_snp_table_7189465491323932_hidden == False
593 | content_learn_more_5383937426324381_key == 5383937426324381
593 | content_learn_more_5383937426324381_blur == True
593 | content_learn_more_5383937426324381_hidden == False
593 | content_learn_more_5383937426324381_text == Based on the variants we looked at, your CCND1 gene is associated with somewhat higher odds of melanoma, relative to other variants. However, this doesn't necessarily reflect your overall risk of melanoma; it’s just one gene related to it. Reducing alcohol intake, adhering to the Mediterranean diet, and supplementing with vitamin D may help. Keep scrolling to find out more.
593 | content_recommendation_7967366276533201_key == 7967366276533201
593 | content_recommendation_7967366276533201_blur == True
593 | content_recommendation_7967366276533201_hidden == False
rsIDs = rs498136
rsStatus = rs498136,,chr11,69552350,A,C,,,13,20,HET
