596 | id == 596
596 | category_id == 63
596 | category_order == 28
596 | category_name == Skin Health
596 | category_color == #C47AC0
596 | slug == IRX3-melanoma
596 | title == Is There a Relationship Between Body Weight & Melanoma? (IRX3)
596 | meta_description == A variant of both IRX3 & FTO has been associated with melanoma. Where does this connection come from? Read on to learn more.
596 | summary == <p><strong>A variant that alters the expression of both <em>IRX3 </em>&amp; <em>FTO </em>has been associated with melanoma. Where does this connection come from? Read on to learn more.</strong></p>
596 | overall_score_text == Your Melanoma Score (based on IRX3)
596 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IRX3-Melanoma.jpg
596 | author_id == 1
596 | author_name == Jasmine Foster
596 | author_title == BSc, BEd
596 | author_order == 36
596 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
596 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
596 | reviewer == None
596 | medical_reviewer_id == 11
596 | medical_reviewer_name == Puya Yazdi
596 | medical_reviewer_title == MD
596 | publish_date == 2021
596 | publish_date == 1
596 | publish_date == 11
596 | avg_rating == 5.0
596 | tags_id == 164
596 | tags_name == Cancer
596 | tags_id == 570
596 | tags_name == Fat Metabolism
596 | tags_id == 199
596 | tags_name == FTO Gene
596 | tags_id == 1121
596 | tags_name == IRX3 Gene
596 | tags_id == 1100
596 | tags_name == Melanoma
596 | tags_id == 140
596 | tags_name == Metabolism
596 | tags_id == 1101
596 | tags_name == Skin Cancer
596 | tags_id == 232
596 | tags_name == Vitamin D
596 | tags_id == 115
596 | tags_name == Weight Gain
596 | permissions_favorite == False
596 | permissions_rate == False
596 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">IRX3 </span></em><span style="font-weight: 400;">encodes Iroquois homeobox 3. Variants of </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> may play a role in melanoma by disrupting tumor suppressor activities. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by directly increasing IRX3 or addressing downstream effects of low IRX3 levels.</span></p> <h2><strong><em>IRX3 </em></strong><strong>and Melanoma</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/irx3/"><em><span style="font-weight: 400;">IRX3</span></em></a><span style="font-weight: 400;"> gene encodes Iroquois homeobox 3, a protein known mainly for its role in the development of the nervous system [</span><a href="https://www.ncbi.nlm.nih.gov/gene/79191"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some research suggests that </span><em><span style="font-weight: 400;">IRX3 </span></em><span style="font-weight: 400;">may prevent the development of tumor cells. In one study of women who underwent surgery for breast cancer, those who died within 5 years after the surgery had significantly lower </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> expression compared to those who survived for longer. The mechanism for this protective effect is unknown [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715957/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16937283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One variant in </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> has been associated with relative incidence of melanoma. Oddly, this variant also alters the expression of </span><em><span style="font-weight: 400;">FTO</span></em><span style="font-weight: 400;">, a gene that regulates weight gain and strongly affects susceptibility to obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640814/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have investigated whether the </span><em><span style="font-weight: 400;">FTO</span></em><span style="font-weight: 400;"> gene might have a functional effect on melanoma. However, there is no obvious reason that a gene known for affecting weight gain would also affect melanoma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640814/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">A variant that alters the expression of both </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">FTO</span></em><span style="font-weight: 400;"> has been associated with melanoma, though its exact mechanism of effect is unknown.</span></span></p> <h2><strong>Your </strong><strong><em>IRX3</em></strong><strong> Results for Melanoma</strong></h2> <p>*2307260588411455*</p> <p><a href="https://selfdecode.com/gene/irx3/"><strong><em>IRX3</em></strong></a> <a href="https://selfdecode.com/snp/rs16953002/"><strong>rs16953002</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower rates of melanoma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher rates of melanoma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may reduce IRX3 activity, leading to increased rates of tumour cell development [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715957/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16937283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*9994143825322919*</p> <h2><strong>Recommendations for Preventing Melanoma</strong></h2> <p>*3068201347671158*</p> <h3><strong>Maintain a Healthy Weight</strong></h3> <p><span style="font-weight: 400;">Both </span><em><span style="font-weight: 400;">FTO </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> have been implicated in weight gain and obesity. Furthermore, </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> gene expression increased in overweight teenagers undergoing an intensive </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> program of diet and </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;">. This result suggests that diet and exercise changes aimed at reaching and maintaining a healthy weight may also benefit </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> expression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534854/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Being obese or overweight was associated with an increased risk of melanoma in 21 studies of almost 25,000 men [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11552707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8166137/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23200191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">Weight loss</span></a><span style="font-weight: 400;"> may also help improve the effectiveness of chemotherapeutic drugs for melanoma, as seen in a study in mice [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142287/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Weight management strategies may increase </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> and reduce the incidence of melanoma.</span></span></p> <h3><strong>Vitamin D</strong></h3> <p><span style="font-weight: 400;">People with certain variants that affect both the </span><em><span style="font-weight: 400;">FTO </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> genes may be more susceptible to the damaging effects of vitamin D deficiency. Thus, if you have detrimental alleles at </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;">, you should be extra careful to ensure that you get enough vitamin D [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595530/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research has found no association between blood </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> levels and risk of melanoma, but deficiency in this vitamin predicted a poorer outcome in 2 studies of over 1000 people with melanoma. In a placebo-controlled trial of over 3k women, supplementation with vitamin D and </span><a href="https://selfhacked.com/blog/calcium-101/"><span style="font-weight: 400;">calcium</span></a><span style="font-weight: 400;"> reduced the incidence of melanoma in those with a history of other skin cancer types [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695831/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22880705/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773226/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157967/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with detrimental variants in the </span><em><span style="font-weight: 400;">IRX3</span></em><span style="font-weight: 400;"> gene may be more susceptible to the damaging effects of vitamin D deficiency, which has also been linked to worse outcomes in melanoma patients.</span></span></p>
596 | content_snp_table_2307260588411455_key == 2307260588411455
596 | content_snp_table_2307260588411455_blur == True
596 | content_snp_table_2307260588411455_hidden == False
596 | content_learn_more_9994143825322919_key == 9994143825322919
596 | content_learn_more_9994143825322919_blur == True
596 | content_learn_more_9994143825322919_hidden == False
596 | content_learn_more_9994143825322919_text == Based on the variants we looked at, your IRX3 gene is somewhat associated with tumor development. However, this doesn't necessarily reflect your overall risk of melanoma; it’s just one gene related to it. Maintaining a healthy weight and supplementing vitamin D may help. Keep scrolling to find out more.
596 | content_recommendation_3068201347671158_key == 3068201347671158
596 | content_recommendation_3068201347671158_blur == True
596 | content_recommendation_3068201347671158_hidden == False
rsIDs = rs16953002
rsStatus = rs16953002,FTO,chr16,54080912,G,A,C,,33,0,Normal
