601 | id == 601
601 | category_id == 96
601 | category_order == 29
601 | category_name == Blood Pressure
601 | category_color == #C47AC0
601 | slug == ABO-blood-pressure
601 | title == The Role of the Blood Type Gene in High Blood Pressure (ABO)
601 | meta_description == The ABO gene determines blood type in humans and may affect other health markers. How is it linked to blood pressure?
601 | summary == <p><strong>The <em>ABO </em>gene determines blood type in humans and may affect other health markers. How is it linked to blood pressure? Read on to find out.</strong></p>
601 | overall_score_text == Your Blood Pressure Score (based on ABO)
601 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ABO-Blood-Pressure.jpg
601 | author_id == 1
601 | author_name == Jasmine Foster
601 | author_title == BSc, BEd
601 | author_order == 36
601 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
601 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
601 | reviewer == None
601 | medical_reviewer_id == 11
601 | medical_reviewer_name == Puya Yazdi
601 | medical_reviewer_title == MD
601 | publish_date == 2021
601 | publish_date == 1
601 | publish_date == 13
601 | avg_rating == 5.0
601 | tags_id == 451
601 | tags_name == ABO Gene
601 | tags_id == 172
601 | tags_name == Blood Pressure
601 | tags_id == 452
601 | tags_name == Blood Type
601 | tags_id == 152
601 | tags_name == Cholesterol
601 | tags_id == 1134
601 | tags_name == E-Selectin
601 | tags_id == 335
601 | tags_name == Hypertension
601 | tags_id == 24
601 | tags_name == Inflammation
601 | tags_id == 903
601 | tags_name == Melatonin
601 | permissions_favorite == False
601 | permissions_rate == False
601 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">ABO</span></em><span style="font-weight: 400;"> is the major gene that determines blood type in humans. Variants of </span><em><span style="font-weight: 400;">ABO</span></em><span style="font-weight: 400;"> may play a role in blood pressure by increasing levels of the inflammatory protein E-selectin. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing E-selectin and other markers of inflammation in the blood vessels.</span></p> <h2><strong><em>ABO</em></strong><strong> and Blood Pressure</strong></h2> <p><a href="https://selfdecode.com/gene/abo/"><em><span style="font-weight: 400;">ABO</span></em></a> <span style="font-weight: 400;">is the major gene that determines blood type in humans. Several variants combine to determine blood type, the major ones being rs8176719, rs8176746, and rs8176747. Using these SNPs, researchers can identify whether someone has an A, B, AB, or O blood type [</span><a href="https://ghr.nlm.nih.gov/gene/ABO"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have known for decades that blood type has far-reaching associations with health markers, including [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1980378/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/3997161/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.119.313658"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Blood fat levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Heart disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Healthy aging</span></li> </ul> <p><span style="font-weight: 400;">People with O blood type may have some protection from </span><a href="https://selfdecode.com/blog/article/abo-blood-type-covid-235/"><span style="font-weight: 400;">some viral infections</span></a><span style="font-weight: 400;">, but also develop high blood pressure at a higher rate than any other blood type [</span><a href="https://www.thelancet.com/article/S0140-6736(20)30251-8/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.119.313658"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">There are also variants in the </span><em><span style="font-weight: 400;">ABO</span></em><span style="font-weight: 400;"> gene that do not affect conventional blood type, but do affect health measures. One variant, </span><a href="https://selfdecode.com/snp/rs579459/"><span style="font-weight: 400;">rs579459</span></a><span style="font-weight: 400;">, does not contribute to ABO blood type but is strongly associated with blood pressure and cholesterol [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Each allele of the rs579459 variant is associated with different potential health problems: the &lsquo;T&rsquo; allele is linked with higher blood pressure, but lower blood cholesterol. The reason for this difference is not well understood, but may have to do with the expression of E-selectin, an inflammatory molecule that makes white blood cells stick to blood vessel walls [</span><a href="https://www.ahajournals.org/doi/10.1161/atvbaha.109.192971"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/6401"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29178542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5><span style="font-weight: 400;">Summary</span></h5> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ABO</span></em><span style="font-weight: 400;"> gene determines blood type in humans. It also affects markers of health like blood fat levels and blood pressure, possibly due to variation in inflammatory E-selectin levels.</span></p> <h2><strong>Your </strong><strong><em>ABO</em></strong><strong> Results for Blood Pressure</strong></h2> <p>*7180426195664356*</p> <p><a href="https://selfdecode.com/gene/abo/"><strong>ABO</strong></a> <a href="https://selfdecode.com/snp/rs579459/"><strong>rs579459</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with relatively higher blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with relatively lower blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may alter the activity of E-selectin, leading to a decrease in blood pressure [</span><a href="https://www.ahajournals.org/doi/10.1161/atvbaha.109.192971"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/6401"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29178542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*7230228166761645*</p> <h2><strong>Recommendations for Reducing Blood Pressure</strong></h2> <p>*5196299045911588*</p> <p><span style="font-weight: 400;">There is no known advantage or disadvantage to increasing or decreasing the quantity of A or B antigens produced in the blood. These recommendations will therefore focus on strategies that decrease blood pressure and have beneficial effects on E-selectin levels.</span></p> <h3><strong>A Note on Blood Group Diets</strong></h3> <p><span style="font-weight: 400;">Some people believe that certain diets are better for different blood types. The so-called &ldquo;blood type diet&rdquo; or &ldquo;blood group diet&rdquo; was popularized by P. J. D&rsquo;Adamo in his 1996 book Eat Right For Your Type. However, while these specialized diets have been associated with positive health outcomes, their benefits were not specific to any single blood type, and none has been found to decrease blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893150/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Maintain a Healthy Weight</strong></h3> <p><span style="font-weight: 400;">Obese people tend to have significantly higher E-selectin levels than people at a healthy weight. Furthermore, obese patients undergoing weight loss programs show decreasing E-selectin levels over time [</span><a href="https://www.sciencedirect.com/science/article/pii/S0899900712002547?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Being overweight or obese, especially if accompanied by excessive visceral fat, is a major risk factor for high blood pressure. Excessive body fat activates the fight-or-flight nervous system, worsens kidney function, increases damage to the blood vessels, and causes </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;"> resistance</span></a><span style="font-weight: 400;">, all of which increases blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28532816/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12196085/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple studies show that interventions with increased physical activity and special diets causing a ~5-kg </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> lower systolic (by ~4.5 mmHg) and diastolic (by ~3.4 mmHg) blood pressure. As expected, losing more weight led to larger blood pressure reduction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12975389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5><span style="font-weight: 400;">Summary</span></h5> <p><span style="font-weight: 400;">People who are overweight or obese have higher E-selectin levels and tend to have higher blood pressure than those who are at a healthy weight.</span></p> <h3><strong>Avoid Cigarettes</strong></h3> <p><span style="font-weight: 400;">Cigarette smoke has been found to increase E-selectin levels on contact with some cell types [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19107907/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Smoking causes an immediate but reversible increase in systolic and diastolic blood pressure mainly due to </span><a href="https://selfhacked.com/blog/28-proven-health-benefits-nicotine-4-potential-risks/"><span style="font-weight: 400;">nicotine</span></a><span style="font-weight: 400;">. Over time, smoking gradually damages the blood vessels and raises central blood pressure. As a result, it increases the risk of organ damage, especially in people with high baseline blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9162447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20550499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31391430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27197683/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Electronic cigarettes may also raise blood pressure, especially if they contain nicotine. However, switching from tobacco smoking to electronic cigarettes may improve blood pressure regulation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/33230755/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30823865/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In children and adolescents, passive exposure to tobacco smoke significantly increases systolic blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31113399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5><span style="font-weight: 400;">Summary</span></h5> <p><span style="font-weight: 400;">Cigarette smoke exposure may increase E-selectin. It also damages the blood vessels and raises blood pressure over time.</span></p> <h3><strong>Increase Potassium Intake</strong></h3> <p><a href="https://selfhacked.com/blog/potassium/"><span style="font-weight: 400;">Potassium</span></a><span style="font-weight: 400;"> lowers arterial blood pressure in people with hypertension, especially if they consume a lot of sodium, but not in those with normal pressure values [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2297825/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9022555/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26634368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Reductions in blood pressure associated with potassium intake may rely on E-selectin, according to a study of Chinese patients with high blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">An increase in potassium intake of at least 0.78 g/day is associated with a significant reduction in systolic (by 4.9 mm Hg) and diastolic (by 2.7 mm Hg) blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061250/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The blood pressure-lowering effect of potassium may be related to its diuretic ability, and activity in the nervous system, blood vessels, the </span><a href="https://selfhacked.com/blog/low-higher-renin-how-to-increase-decrease-renin/"><span style="font-weight: 400;">renin</span></a><span style="font-weight: 400;">-angiotensin-</span><a href="https://selfhacked.com/blog/need-know-aldosterone-health-effects/"><span style="font-weight: 400;">aldosterone</span></a><span style="font-weight: 400;"> system, and natriuretic hormone.</span></p> <h5><span style="font-weight: 400;">Summary</span></h5> <p><span style="font-weight: 400;">Potassium may reduce blood pressure through interactions with E-selectin.</span></p> <h3><strong>Melatonin</strong></h3> <p><span style="font-weight: 400;">Supplementing with </span><a href="https://selfhacked.com/blog/melatonin/"><span style="font-weight: 400;">melatonin</span></a><span style="font-weight: 400;"> may decrease levels of E-selectin and related proteins, according to a study of rats with high blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23869411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 7 studies involving 221 people with nocturnal hypertension found that supplementation with controlled-release (but not fast-release) </span><a href="https://selfhacked.com/blog/melatonin/"><span style="font-weight: 400;">melatonin</span></a><span style="font-weight: 400;"> lowered systolic (by 6.1 mmHg) and diastolic (by 3.5 mmHg) blood pressure. Another meta-analysis of 8 studies and 743 people with metabolic disorders also found melatonin effective at lowering blood pressure&nbsp; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180511/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30647466/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Like </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">, blood pressure has </span><a href="http://selfhacked.com/blog/what-it-means-to-keep-to-a-circadian-rhythm/"><span style="font-weight: 400;">circadian</span></a><span style="font-weight: 400;"> rhythmicity. It increases in the morning and decreases at night. Melatonin shows the opposite pattern, indicating that it may have a role in lowering blood pressure at night. In line with this, activation of the melatonin receptors MT1 and MT2 widens the blood vessels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227197/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5><span style="font-weight: 400;">Summary</span></h5> <p><span style="font-weight: 400;">Melatonin supplementation may decrease blood pressure by reducing E-selectin levels.</span></p>
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601 | content_learn_more_7230228166761645_text == Based on the variants we looked at, your ABO gene is somewhat associated with abnormal E-selectin levels. However, this doesn't necessarily reflect your overall risk of high blood pressure; it’s just one gene related to it. Maintaining a healthy weight, avoiding cigarettes, increasing potassium intake, and supplementing with melatonin may help. Keep scrolling to find out more.
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rsIDs = rs8176747,rs8176746,rs8176719,rs579459
rsStatus = rs8176747,ABO,chr9,133255928,C,A,G,,20,0,Normal
rsStatus = rs8176746,ABO,chr9,133255935,G,A,T,,20,0,Normal
rsStatus = rs579459,,chr9,133278724,C,T,,,13,10,HET
