606 | id == 606
606 | category_id == 96
606 | category_order == 29
606 | category_name == Blood Pressure
606 | category_color == #C47AC0
606 | slug == NPR3-blood-pressure
606 | title == Sodium-Eliminating Substances & Their Role in Blood Pressure (NPR3)
606 | meta_description == NPR3 clears blood pressure-altering substances. Variants of NPR3 are linked to high blood pressure. Read more here.
606 | summary == <p style="text-align:justify"><strong>The <em>NPR3</em> gene clears blood pressure-altering substances from the body. How might variants of <em>NPR3</em> increase the risk of high blood pressure? Read more to find out.</strong><br />  &nbsp;</p>
606 | overall_score_text == Your Blood Pressure Score (based on NPR3 gene)
606 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NPR3-Blood-Pressure.jpg
606 | author_id == 14
606 | author_name == Shany Lahan
606 | author_title == MS (Neuroscience)
606 | author_order == 5
606 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
606 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
606 | reviewer == None
606 | medical_reviewer_id == 11
606 | medical_reviewer_name == Puya Yazdi
606 | medical_reviewer_title == MD
606 | publish_date == 2021
606 | publish_date == 1
606 | publish_date == 18
606 | avg_rating == 5.0
606 | tags_id == 372
606 | tags_name == Blood vessels
606 | tags_id == 1154
606 | tags_name == Blood Volume
606 | tags_id == 1139
606 | tags_name == High Blood Pressure
606 | tags_id == 335
606 | tags_name == Hypertension
606 | tags_id == 1146
606 | tags_name == Kidneys
606 | tags_id == 1153
606 | tags_name == Natriuretic Peptides
606 | tags_id == 1152
606 | tags_name == NPR3 Gene
606 | tags_id == 334
606 | tags_name == Sodium
606 | tags_id == 674
606 | tags_name == Vasodilation
606 | permissions_favorite == False
606 | permissions_rate == False
606 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">NPR3 </span></em><span style="font-weight: 400;">codes for a receptor that modulates blood pressure by clearing natriuretic (&ldquo;sodium-eliminating&rdquo;) peptides. Variants of </span><em><span style="font-weight: 400;">NPR3 </span></em><span style="font-weight: 400;">may play a role in high blood pressure by altering NPR3 production or activity. Lifestyle and diet modifications may counteract the effects of these variants by balancing levels of natriuretic peptides.</span></span></p> <h2 style="text-align: justify;"><strong><em>NPR3</em></strong><strong> and Blood Pressure</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">After eating salty foods, the body normally attempts to dilute the high levels of sodium by retaining water. Excessive water retention increases your blood volume, which puts more pressure on blood vessels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28501304/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">Natriuretic peptides</span></em><span style="font-weight: 400;"> are short chains of amino acids that help regulate blood pressure by stimulating the kidneys to eliminate sodium (&ldquo;natri&rdquo;) via the urine (&ldquo;uretic&rdquo;). These peptides are also able to promote blood vessel dilation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412747/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23524910/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/npr3/"><em><span style="font-weight: 400;">NPR3</span></em></a> <span style="font-weight: 400;">gene codes for natriuretic peptide receptor 3 (NPR3). NPR3 binds circulating natriuretic peptides</span> <span style="font-weight: 400;">and clears them from the body [</span><a href="https://www.ncbi.nlm.nih.gov/gene/4883"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">While the description above implies that high levels of NPR3 may raise blood pressure by lowering the availability of natriuretic peptides, one recent study has reported that activation of NPR3 by C-type natriuretic peptide may instead mediate blood vessel dilation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178781/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Moreover, a recent study linked the blood pressure-raising &lsquo;G&rsquo; allele at SNP </span><a href="https://selfdecode.com/snp/rs1173771/"><span style="font-weight: 400;">rs1173771</span></a><span style="font-weight: 400;"> to reduced production of NPR3 in muscle cells that line blood vessels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886068/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Taken together, the above studies suggest that the effects of NPR3 are dependent on the type of natriuretic peptide that binds to it, and the type of cell in which it&rsquo;s found [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27686019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">NPR3 </span></em><span style="font-weight: 400;">have been associated with high blood pressure. These variants may alter the production or activity of NPR3, resulting in elevated blood volumes and contraction of blood vessels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <h2 style="text-align: left;"><strong>Your </strong><strong><em>NPR3</em></strong><strong> Results for Blood Pressure</strong></h2> <p style="text-align: justify;">*2178043536199887*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>NPR3 </em></strong><a href="https://selfdecode.com/snp/rs1173771/"><strong>rs1173771</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Higher odds of high blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with high blood pressure</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>NPR3 </em></strong><a href="https://selfdecode.com/snp/rs1173727/"><strong>rs1173727</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Higher odds of high blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with high blood pressure</span></li> </ul> <p style="text-align: justify;">*6946361283634415*</p> <h2 style="text-align: left;"><strong>Recommendations for Lowering Blood Pressure</strong></h2> <p style="text-align: justify;">*6598142807799583*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Maintaining a Healthy Weight</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Obesity may significantly lower levels of natriuretic peptides, thus further exacerbating the negative effects of </span><em><span style="font-weight: 400;">NPR3 </span></em><span style="font-weight: 400;">risk variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14769680/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Being overweight or obese, especially if accompanied by excessive visceral fat, is a major risk factor for high blood pressure. Excessive body fat activates the fight-or-flight nervous system, worsens kidney function, increases damage to the blood vessels, and causes </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;"> resistance</span></a><span style="font-weight: 400;">, all of which increase blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28532816/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12196085/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies show that interventions with increased physical activity and special diets causing a ~5-kg </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> lower systolic (by ~4.5 mmHg) and diastolic (by ~3.4 mmHg) blood pressure. As expected, losing more weight led to larger blood pressure reduction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12975389/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Maintaining a healthy weight may lower blood pressure by balancing natriuretic peptide levels.</span></p> <h4 style="text-align: justify;"><strong>Avoiding Heavy Alcohol Intake</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Levels of natriuretic peptides have been shown to rise alongside alcohol consumption, suggesting that heavy drinking may significantly increase natriuretic peptide production and NPR3 activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16923450/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Moderate alcohol intake (14-28 g/day) temporarily lowers systolic (by 5.6 mmHg) and diastolic (by 4 mmHg) blood pressure within the first 6 hours. Heavy drinking also lowers blood pressure within the first 12, but raises systolic (by 3.7 mmHg) and diastolic (by 2.4 mmHg) blood pressure afterwards. Long-term heavy drinking damages the heart and blood vessels, further worsening high blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15752957/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32609894/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A meta-analysis of 36 trials involving 2,865 people found that reducing alcohol intake lowers systolic (by 5.5 mmHg) and diastolic (by 3.97 mmHg) blood pressure in people drinking more than 2 drinks per day. The effect was strongest in very heavy drinkers (over 6 drinks per day) who reduced their intake by at least 50% [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoiding heavy alcohol intake may lower blood pressure by balancing natriuretic peptide levels and NPR3 activity.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Reducing Sodium Intake</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The body compensates for high sodium intake in part by increasing natriuretic peptide production. This suggests that reducing sodium intake may help balance natriuretic peptide levels and NPR3 activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24689065/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Health professionals worldwide recommend restricting sodium intake because it increases blood pressure, which is one of the strongest risk factors for heart disease and stroke [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089690/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A meta-analysis of 34 clinical trials involving 3,230 people found that, in those with high blood pressure, reducing </span><a href="https://selfhacked.com/blog/is-salt-good-or-bad-the-science-on-the-health-effects-of-salt/"><span style="font-weight: 400;">salt</span></a><span style="font-weight: 400;"> lowers systolic (by 5.4 mmHg) and diastolic (by 2.8 mmHg) blood pressure. Individuals with normal blood pressure show a reduction of 2.4 and 1.0 mmHg [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23558162/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In another meta-analysis of 11 studies, using salt substitutes (such as </span><a href="https://selfhacked.com/blog/potassium/"><span style="font-weight: 400;">potassium</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">magnesium</span></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/calcium-101/"><span style="font-weight: 400;">calcium</span></a><span style="font-weight: 400;"> salts) lowered systolic (by 8.87 mmHg) and diastolic (by 4.04 mmHg) blood pressure in people with high blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047420/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, restricting salt may not have direct effects on the risk of death or cardiovascular disease, even in people diagnosed with high blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21540421/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9519949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Reducing sodium intake may lower blood pressure by balancing natriuretic peptide levels and NPR3 activity.</span></p>
606 | content_snp_table_2178043536199887_key == 2178043536199887
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606 | content_snp_table_2178043536199887_hidden == False
606 | content_learn_more_6946361283634415_key == 6946361283634415
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606 | content_learn_more_6946361283634415_hidden == False
606 | content_learn_more_6946361283634415_text == Based on the variants we looked at, your NPR3 gene makes you somewhat more likely to have high blood pressure. However, this doesn't necessarily reflect your overall risk of high blood pressure; it’s just one gene related to it. Reducing sodium intake, maintaining a healthy weight, and avoiding heavy alcohol intake may help. Keep scrolling to find out more.
606 | content_recommendation_6598142807799583_key == 6598142807799583
606 | content_recommendation_6598142807799583_blur == True
606 | content_recommendation_6598142807799583_hidden == False
rsIDs = rs1173727,rs1173771
rsStatus = rs1173727,,chr5,32830415,T,A,C,G,25,0,Normal
rsStatus = rs1173771,,chr5,32814922,A,G,,,18,14,HET
