607 | id == 607
607 | category_id == 96
607 | category_order == 29
607 | category_name == Blood Pressure
607 | category_color == #C47AC0
607 | slug == TWIST1-blood-pressure
607 | title == The Wnt Signalling Pathway in High Blood Pressure (TWIST1)
607 | meta_description == TWIST1 encodes a target of the Wnt signalling pathway. How does this pathway increase blood pressure? Read on to learn more.
607 | summary == <p><strong>TWIST1 encodes a target of the Wnt signalling pathway. How does this pathway increase blood pressure? Read on to learn more.</strong></p>
607 | overall_score_text == Your Blood Pressure Score (based on TWIST1)
607 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TWIST1-Blood-Pressure.jpg
607 | author_id == 1
607 | author_name == Jasmine Foster
607 | author_title == BSc, BEd
607 | author_order == 36
607 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
607 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
607 | reviewer == None
607 | medical_reviewer_id == 11
607 | medical_reviewer_name == Puya Yazdi
607 | medical_reviewer_title == MD
607 | publish_date == 2021
607 | publish_date == 1
607 | publish_date == 18
607 | avg_rating == 5.0
607 | tags_id == 172
607 | tags_name == Blood Pressure
607 | tags_id == 372
607 | tags_name == Blood vessels
607 | tags_id == 270
607 | tags_name == EGCG
607 | tags_id == 335
607 | tags_name == Hypertension
607 | tags_id == 1155
607 | tags_name == Smooth Muscle
607 | tags_id == 1030
607 | tags_name == TWIST1 Gene
607 | tags_id == 1049
607 | tags_name == Wnt
607 | tags_id == 1031
607 | tags_name == Wnt Signalling
607 | permissions_favorite == False
607 | permissions_rate == False
607 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">TWIST1</span></em><span style="font-weight: 400;"> encodes twist family bHLH transcription factor 1. Variants of </span><em><span style="font-weight: 400;">TWIST1</span></em><span style="font-weight: 400;"> may play a role in high blood pressure by increasing Wnt signalling activity. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing Wnt signalling.</span></p> <h2><strong><em>TWIST1</em></strong><strong> and Blood Pressure</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/twist1/"><em><span style="font-weight: 400;">TWIST1</span></em></a> <span style="font-weight: 400;">gene encodes a protein called twist family bHLH transcription factor 1. This protein helps determine what types of cells will be formed during early development and differentiation. It is most active during the growth of the embryo and fetus; in adults, it is believed to play a role in the growth and maintenance of bone [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7291"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TWIST1 is a target of the Wnt/beta-catenin signalling pathway, which helps transport signal molecules across the cell membrane and into the cell. Wnt is essential for cell movement and differentiation during early development; excessive Wnt signalling activity has also been implicated in many types of cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715624/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634250/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.jidonline.org/article/S0022-202X(15)36283-7/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/80326"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Wnt signalling may also increase blood pressure. According to one review, Wnt increases the strength of contraction of smooth muscles in the walls of blood vessels, increasing blood pressure that way [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508596/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">TWIST1</span></em><span style="font-weight: 400;"> encodes twist family bHLH transcription factor 1, a target of the Wnt signalling pathway. Wnt increases blood pressure by contracting the smooth muscles in blood vessel walls.</span></span></p> <h2><strong>Your </strong><strong><em>TWIST1</em></strong><strong> Results for Blood Pressure</strong></h2> <p>*5418628383134914*</p> <p><a href="https://selfdecode.com/gene/twist1/"><strong>TWIST1</strong></a> <a href="https://selfdecode.com/snp/rs2107595/"><strong>rs2107595</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/s41588-018-0303-9"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher blood pressure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may increase Wnt signalling, leading to increased contraction of&nbsp;</span></li> </ul> <p>*3706889070168635*</p> <h2><strong>Recommendations for Reducing Blood Pressure</strong></h2> <p>*5891218010039705*</p> <h3><strong>Acupuncture</strong></h3> <p><span style="font-weight: 400;">Some forms of acupuncture may regulate the Wnt signalling pathway, though this effect has only been demonstrated in animals so far [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806613/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26296359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">Acupuncture</span></a><span style="font-weight: 400;"> has been suggested to help with high blood pressure in several trials. However, the authors of the different meta-analysis warned that acupuncture was only effective as an add-on to conventional therapy and pointed out the low quality, high heterogeneity, and lack of long-term effects observed in most studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19008863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514875/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963739/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516840/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture may decrease blood pressure through the Wnt signalling pathway, but the evidence is limited and of low quality.</span></p> <h3><strong>Mediterranean Diet</strong></h3> <p><span style="font-weight: 400;">The Mediterranean diet is a popular anti-inflammatory diet rich in active polyphenols from fruits and vegetables. These include quercetin, resveratrol, and sulforaphane, each of which has been shown to inhibit Wnt signalling [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 30 clinical trials found that adherence to a Mediterranean diet helps prevent heart disease by lowering systolic (by ~3 mmHg) and diastolic (by ~2 mmHg) blood pressure in people with normal values. In those with hypertension, this diet lowered systolic blood pressure by 1.44 mmHg and diastolic blood pressure by 0.7 mmHg [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26483006/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When compared to other diets, the Mediterranean diet is especially effective at lowering diastolic blood pressure. A meta-analysis found it only effective for this purpose, while another one ranked it 3rd in terms of diastolic pressure-lowering effect (after the DASH and Paleolithic diets) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26902492/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29718689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet is rich in polyphenols that have been found to block Wnt signalling and reduce blood pressure.</span></p> <h3><strong>Green Tea</strong></h3> <p><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;">, the main active compound in green tea, has been found to decrease Wnt signalling [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037968/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Four meta-analyses found that drinking at least one cup of </span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;"> per day lowered systolic and diastolic blood pressure by ~2.5 mmHg each [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24675010/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25137341/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">EGCG is also available as a supplement.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">EGCG from green tea may block Wnt signalling and reduce blood pressure.</span></p>
607 | content_snp_table_5418628383134914_key == 5418628383134914
607 | content_snp_table_5418628383134914_blur == True
607 | content_snp_table_5418628383134914_hidden == False
607 | content_learn_more_3706889070168635_key == 3706889070168635
607 | content_learn_more_3706889070168635_blur == True
607 | content_learn_more_3706889070168635_hidden == False
607 | content_learn_more_3706889070168635_text == Based on the variants we looked at, your TWIST1 gene is somewhat associated with dysregulated Wnt signalling. However, this doesn't necessarily reflect your overall risk of high blood pressure; it’s just one gene related to it. Acupuncture, a Mediterranean diet, and green tea may help. Keep scrolling to find out more.
607 | content_recommendation_5891218010039705_key == 5891218010039705
607 | content_recommendation_5891218010039705_blur == True
607 | content_recommendation_5891218010039705_hidden == False
rsIDs = rs2107595
rsStatus = rs2107595,,chr7,19009765,G,A,,,23,0,Normal
