614 | id == 614
614 | category_id == 96
614 | category_order == 29
614 | category_name == Blood Pressure
614 | category_color == #C47AC0
614 | slug == CSK-angiotensin-blood-pressure
614 | title == Do Genes Influence Your Blood Pressure? (CSK)
614 | meta_description == The CSK gene inhibits angiotensin II, a major blood-pressure-increasing protein. Click to check your variants!
614 | summary == <p style="text-align:justify"><strong>The CSK gene inhibits angiotensin II, a major blood-pressure-increasing protein. Read this post to check your variants and get tailored tips!</strong></p>
614 | overall_score_text == Your Blood Pressure Score (based on CSK gene)
614 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CSK-Blood-Pressure.jpg
614 | author_id == 9
614 | author_name == Aleksa Ristic
614 | author_title == MS (Pharmacy)
614 | author_order == 45
614 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
614 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
614 | reviewer == None
614 | medical_reviewer_id == 11
614 | medical_reviewer_name == Puya Yazdi
614 | medical_reviewer_title == MD
614 | publish_date == 2021
614 | publish_date == 1
614 | publish_date == 22
614 | avg_rating == 5.0
614 | tags_id == 1165
614 | tags_name == ACE inhibitors
614 | tags_id == 746
614 | tags_name == Angiotensin II
614 | tags_id == 172
614 | tags_name == Blood Pressure
614 | tags_id == 1164
614 | tags_name == CSK gene
614 | tags_id == 423
614 | tags_name == RAS system
614 | permissions_favorite == False
614 | permissions_rate == False
614 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The CSK gene suppresses the production of angiotensin II, a major blood-pressure-increasing protein.<br /><br /></strong><strong>Specific gene variants have been associated with relatively higher blood pressure. They likely reduce CSK activity and increase angiotensin II levels.<br /><br /></strong><strong>Read this post to learn about natural ways to control blood pressure by targeting the CSK gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>The CSK Gene &amp; Blood Pressure</strong></h2> <p><span style="font-weight: 400;">The </span><em><a href="https://selfdecode.com/gene/csk/"><span style="font-weight: 400;">CSK</span></a></em><span style="font-weight: 400;"> gene helps make a protein that suppresses angiotensin II production. Angiotensin II is the key component of the renin-angiotensin system (RAS). It raises blood pressure by shrinking the blood vessels, increasing blood volume, and activating the sympathetic nervous system [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27620391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12402502/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Popular blood pressure drugs, ACE inhibitors, target the RAS system by inhibiting the enzyme that produces angiotensin II [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK431051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><strong><em>Did you know?</em></strong><span style="font-weight: 400;"> The CSK gene belongs to a group of 21 genes associated with blood pressure. Using cutting-edge genetic methods, scientists concluded that, of all those genes, CSK is most likely the one directly influencing blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <h2><strong>Your CSK Results for Blood Pressure</strong></h2> <p>*7767355534481619*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs6495122/"><strong><span style="text-decoration: underline;">rs6495122</span></strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370207/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively lower blood pressure</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively higher blood pressure</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may increase angiotensin II levels by reducing CSK activity.</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs1378942/"><strong><span style="text-decoration: underline;">rs1378942</span></strong></a> <span style="font-weight: 400;">[</span><a href="https://www.nature.com/articles/s41588-018-0303-9"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span><strong>:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively lower blood pressure</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher blood pressure</span></li> <li style="font-weight: 400;" aria-level="1"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase angiotensin II levels by reducing CSK activity.</span></li> </ul> <p>*5648090099513114*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Blood Pressure</strong></h2> <p>*8522555373043761*</p> <h3><strong>Garlic</strong></h3> <p><a href="https://selfhacked.com/blog/garlic-health-benefits/"><span style="font-weight: 400;">Garlic</span></a><span style="font-weight: 400;"> may act as a </span><a href="https://selfhacked.com/blog/5-natural-ace-inhibitors-with-clinical-trials/"><span style="font-weight: 400;">natural ACE inhibitor</span></a><span style="font-weight: 400;"> and reduce angiotensin II levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24461311"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27293465"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several meta-analyses found that supplementation with a </span><a href="https://selfhacked.com/blog/garlic-health-benefits/"><span style="font-weight: 400;">garlic</span></a><span style="font-weight: 400;"> extract (600-2,400 mg/day) may lower systolic (by 7-16 mmHg) and diastolic (by 5-9 mmHg) blood pressure. Garlic may be effective only in people with high blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442048/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19017826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26764327/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25557383/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25239480/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26764326/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Garlic may reduce blood pressure by targeting your CSK variants.</span></p> <h3><strong>Hibiscus</strong></h3> <p><a href="https://selfhacked.com/blog/hibiscus/"><span style="font-weight: 400;">Hibiscus</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Hibiscus</span></em> <em><span style="font-weight: 400;">sabdariffa</span></em><span style="font-weight: 400;">) tea may lower systolic (by 4.71-7.58 mmHg) and diastolic (by 3.53-4.08 mmHg) blood pressure, according to two meta-analyses and four trials of people with high blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25875025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31943427/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20018807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23725524/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10404421/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412462/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A dose adjusted to each person&rsquo;s weight (0.15 g/kg/day) was as effective as drug treatment in two studies. Similarly, hibiscus tea (10 g/day) was as effective as an ACE inhibitor (lisinopril) in one trial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621677/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26289514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15330492/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Hibiscus may lower blood pressure in part by acting as a natural ACE inhibitor and reducing angiotensin II levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17315307/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Consider drinking hibiscus tea to lessen the impact of your CSK gene on blood pressure.</span></p> <h3><strong>Casein Peptides</strong></h3> <p><span style="font-weight: 400;">Casein is the primary protein from dairy products. Research has identified several peptides inside casein that can inhibit ACE [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28290283"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29606478"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplementation with casein tripeptides may lower systolic (by 1.28-5.63 mmHg) and diastolic (by 0.59-1.51 mmHg) blood pressure, according to three meta-analyses. Casein peptides were most effective in Japanese populations [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565599/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633157/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Casein peptides may reduce blood pressure by targeting your gene variants.</span></p>
614 | content_snp_table_7767355534481619_key == 7767355534481619
614 | content_snp_table_7767355534481619_blur == True
614 | content_snp_table_7767355534481619_hidden == False
614 | content_learn_more_5648090099513114_key == 5648090099513114
614 | content_learn_more_5648090099513114_blur == True
614 | content_learn_more_5648090099513114_hidden == False
614 | content_learn_more_5648090099513114_text == Based on the variants we looked at, your CSK gene is associated with average or relatively higher blood pressure. However, this doesn't necessarily reflect your overall risk of high blood pressure; it’s just one gene related to it. Consume more garlic and drink hibiscus tea to reduce the impact of your gene variants on blood pressure. Keep scrolling to find out more.
614 | content_recommendation_8522555373043761_key == 8522555373043761
614 | content_recommendation_8522555373043761_blur == True
614 | content_recommendation_8522555373043761_hidden == False
rsIDs = rs1378942,rs6495122
rsStatus = rs1378942,CSK,chr15,74785026,C,A,T,,6,32,HET
rsStatus = rs6495122,,chr15,74833304,A,C,,,10,22,HET
